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10,916 Possible Causes for activating, factor, formation, platelet

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  • Heparin-induced Thrombocytopenia

    ., the diagnosis should be based on the concurrence of an appropriate clinical picture together with detection of platelet-activating and/or platelet factor 4-dependent antibodies[ncbi.nlm.nih.gov] We evaluated the association between clinical outcomes and platelet-activating profiles assessed by a platelet microparticle assay (PMA), which detects activation of washed[ncbi.nlm.nih.gov] Here, we visualized thrombus formation in an in vivo murine model and an endothelialized microfluidic system that simulate the pathogenesis of HIT. hPF4 released from platelets[ncbi.nlm.nih.gov] FcγRI has also been reported to be involved in monocyte activation by HIT IgG antibodies and synthesis of tissue factor.[ncbi.nlm.nih.gov]

  • Thrombotic Thrombocytopenic Purpura

    BACKGROUND: Platelet microparticles (PMPs) have a procoagulant activity about 50-100 times greater than active platelets due to high expression of negatively charged phospholipids[ncbi.nlm.nih.gov] INTRODUCTION: Quantitation of ADAMTS13 activity, functional inhibitors, and autoantibodies is crucial in diagnosis and management of thrombotic thrombocytopenic purpura.[ncbi.nlm.nih.gov] These platelet-vWF complexes form small blood clots which circulate in the blood vessels and cause shearing of red blood cells, resulting in their rupture and formation of[en.wikipedia.org] Most cases in adults are caused by acquired autoantibodies that inhibit ADAMTS13, a metalloprotease that cleaves von Willebrand factor within nascent platelet-rich thrombi[ncbi.nlm.nih.gov]

  • Acquired Thrombotic Thrombocytopenic Purpura

    Maximal increase of platelet adhesion was observed under 2,050 s(-1) .[ncbi.nlm.nih.gov] Twenty plasma samples with non-concordant ADAMTS13 activity results, KEYWORDS: ADAMTS13 activity assay; TTP; autoantibodies; flow assay; von Willebrand factor[ncbi.nlm.nih.gov] Accumulation of UL-VWF multimers was measured and formation of platelet (PLT) thrombi after focal or systemic vascular injury was examined.[ncbi.nlm.nih.gov] […] agglutination in patients with thrombotic thrombocytopenic purpura (TTP) appears to be associated with excessive release from endothelial cells of unusually large von Willebrand factor[ncbi.nlm.nih.gov]

  • Disseminated Intravascular Coagulation

    platelet aggregation in DIC.[ncbi.nlm.nih.gov] Plasma ADAMTS-13 activity determined at diagnosis of DIC may help predict the risk of hemorrhagic events during and/or following DIC treatment with hematologic disorders.[ncbi.nlm.nih.gov] Following activation of complement system, the terminal complex C5b-9 causes endotheliopathy via channel formation to the endothelial cell membrane.[ncbi.nlm.nih.gov] Within the JAAM DIC score, PT-INR 1.2 was the most accurate factor for T-DIC diagnosis; sensitivity 60.0%, specificity 100.0%, and accuracy 88.7%.[ncbi.nlm.nih.gov]

  • Bleeding Diathesis

    Additionally, FCA is able to identify discrete platelet activation defects.[ncbi.nlm.nih.gov] Serum plasminogen (40%, normal 72-128%) and alpha 2-antiplasmin (55%, normal 70-145%) activities were decreased.[ncbi.nlm.nih.gov] Factor XIII activity was positively correlated with conventional coagulation parameters and rotational thromboelastometry values, such as maximum clot formation (MCF) extem[ncbi.nlm.nih.gov] These discrepancies between Factor V activities and antigen concentration do not appear to be due to an unstable Factor V molecule or to the presence of a Factor V or Factor[ncbi.nlm.nih.gov]

  • Coagulation Abnormalities

    Platelet aggregation studies should be considered in patients with TSC.[ncbi.nlm.nih.gov] The deficiencies may be the result of consumption of coagulation factors caused by ongoing low-level coagulation activation. possibly due to mononuclear cell activation.[ncbi.nlm.nih.gov] In the MECC group, thrombin-antithrombin complex levels (TaTc), prothrombin fragments (PF1 2) formation and thromboelastography (TEG) clotting times were lower compared to[ncbi.nlm.nih.gov] DVT is caused by an interaction between congenital coagulation abnormalities and acquired risk factors.[ncbi.nlm.nih.gov]

  • Osteoporosis

    Complete blood and platelet counts prior to zoledronic acid infusion were normal (138,000/µL), but had declined slightly from 185,000/µL 2 years ago.[ncbi.nlm.nih.gov] Moreover, compounds 3 , 6 - 9 , and 11 significantly suppressed TRAP activities.[ncbi.nlm.nih.gov] Moreover, inhibition of PI3K/Akt totally blocked the synergistic effects of TNF-α on NF-κB activation as well as osteoclast formation.[ncbi.nlm.nih.gov] The aim of this study was to identify factors associated with osteoporosis treatment in postmenopausal women.A cross-sectional study was carried out from March to August 2013[ncbi.nlm.nih.gov]

  • Arterial Thrombosis

    Platelet transfusions were reported in 10.1% TTP, 7.1% HIT, and 25.8% ITP admissions.[ncbi.nlm.nih.gov] KEYWORDS: Cdc42; Knockout mice; Paladin; Platelet activation; Rac1[ncbi.nlm.nih.gov] In this study we sought to dissect the contribution of Reelin in arterial thrombus formation.[ncbi.nlm.nih.gov] However, it is not known which factors might determine the location of thrombosis.[ncbi.nlm.nih.gov]

  • Von Willebrand Disease

    A vaginal delivery was desired and plans were made for induction of labour at 38 weeks of gestation with platelet cover in view of the progressive fall of the platelet count[ncbi.nlm.nih.gov] KEYWORDS: bleeding score; fibrinolysis; plasminogen activator inhibitor-1; von Willebrand disease[ncbi.nlm.nih.gov] KEYWORDS: gel formation; interference; multiple myeloma; von Willebrand disease[ncbi.nlm.nih.gov] […] with von Willebrand factor (VWF)/Factor VIII concentrate (Humate-P, CSL Behring) during the bridge to VAD replacement.[ncbi.nlm.nih.gov]

  • Factor V Deficiency

    Recently, we have shown that three patients with undetectable plasma FV and mild bleeding symptoms had sufficient residual platelet FV to support thrombin generation in platelet-rich[ncbi.nlm.nih.gov] activate factor X and prothrombin on the surface of activated platelets.[ncbi.nlm.nih.gov] Abstract Coagulation factor V (FV) plays an important role in maintaining the hemostatic balance in both the formation of thrombin in the procoagulant pathway as well as in[ncbi.nlm.nih.gov] BACKGROUND AND OBJECTIVES: Factor V HR2 possesses decreased co-factor activity to activated protein C and an increased ratio of factor V1 to factor V2.[ncbi.nlm.nih.gov]