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4,804 Possible Causes for activation, activity, of, phosphatase, phosphoprotein

Did you mean: amotivation, activity, of, phosphatase, phosphoprotein

  • Hypophosphatasia

    The functions of alkaline phosphatase to bone development and mineralization were reviewed.[ncbi.nlm.nih.gov] […] gene expression was disrupted in HPP cells, including reduced osteopontin (OPN), dentin matrix protein 1 (DMP1), dentin sialophosphoprotein (DSPP), and matrix extracellular phosphoprotein[ncbi.nlm.nih.gov] 323 064 analyzed samples, 1526 had ALP activities CONCLUSIONS: Patients with persistently low ALP activity require further clinical, biochemical, and radiological assessment[ncbi.nlm.nih.gov] Abstract Hypophosphatasia (HPP) results from ALPL mutations leading to deficient activity of the tissue-non-specific alkaline phosphatase isozyme (TNAP) and thereby extracellular[ncbi.nlm.nih.gov] Abstract Hypophosphatasia is an inherited disease characterised by low tissue non-specific alkaline phosphatase (TNSALP) levels and skeletal defects.[ncbi.nlm.nih.gov]

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  • Cantharidin

    Its cytotoxicity is believed to be mediated by the inhibition of serine/threonine protein phosphatase 2A.[ncbi.nlm.nih.gov] Phosphatases/antagonists & inhibitors Phosphoprotein Phosphatases/chemistry* Phosphoprotein Phosphatases/genetics Phosphoprotein Phosphatases/metabolism Protein Binding Protein[ncbi.nlm.nih.gov] Notably, it was observed that CAN exerted specific inhibition on PP2A activity and thereby resulted in the activation of the IKKα/IκBα/NF‑κB pathway.[ncbi.nlm.nih.gov] The objective of the present study was to prepare cantharidin-entrapped non-ionic surfactant vesicles (CTD-NSVs) and evaluate their potential in enhancing the antitumor activities[ncbi.nlm.nih.gov] […] phosphatase) inhibitor Any EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of phosphoprotein phosphatase (EC 3.1.3.16). herbicide A[ebi.ac.uk]

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  • Influenza

    The bound antibodies were detected with an alkaline phosphatase-conjugated antibody against mouse (Sigma).[doi.org] Keywords - PTM i Phosphoprotein Proteomic databases Interaction i Subunit structure i Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA.[uniprot.org] Seasonal influenza activity in the Southern Hemisphere was low overall, with influenza A(H1N1)pdm09 predominating in many regions.[ncbi.nlm.nih.gov] […] accession number CY125947) was cloned into the baculovirus transfer vector pAcGP67-B, in frame with an N-terminal cassette containing a His 6 -tag, a vasodilator-stimulated phosphoprotein[doi.org] Amplicons were prepared for sequencing by incubating them at 37  C for 60 min with 0.5 U of shrimp alkaline phosphatase (Amersham) and 1 U of exonuclease I (Amersham) to inactivate[dx.doi.org]

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  • Osteoporosis

    Biochemical markers, especially intact parathyroid hormone and bone-specific alkaline phosphatase, also may be helpful.[ncbi.nlm.nih.gov] […] and osteoclasts induced from RAW 264.7 macrophage cell line (from murine blood)/Er-Xian Decoction treatment In osteoblasts: 8 proteins upregulated Hmgb1, acidic ribosomal phosphoprotein[doi.org] Moreover, compounds 3 , 6 - 9 , and 11 significantly suppressed TRAP activities.[ncbi.nlm.nih.gov] RESULTS: Osteoprotegerin and bone alkaline phosphatase levels were age-dependent.[ncbi.nlm.nih.gov] […] of physical activity to overcome kinesiophobia.[ncbi.nlm.nih.gov]

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  • Lafora Disease

    Laforin contains a dual specificity phosphatase domain and a carbohydrate-binding module, and is a member of the recently described family of glucan phosphatases.[ncbi.nlm.nih.gov] In the present study, we demonstrate that laforin is a phosphoprotein, as indicated by two-dimensional electrophoresis, and we identify Ser(25) as the residue involved in[ncbi.nlm.nih.gov] […] for glucan phosphatase activity.[ncbi.nlm.nih.gov] […] protein 1 Add BLAST 607 Amino acid modifications Feature key Position(s) Description Actions Graphical view Length Modified residue i 146 Phosphoserine 1 Keywords - PTM i Phosphoprotein[expasy.org] In the present study, we demonstrate that laforin is a phosphoprotein, as indicated by two-dimensional electrophoresis, and we identify Ser 25 as the residue involved in this[biochemj.org]

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  • Herpes Simplex Virus 1 Infection

    Analyses of blood samples reveal leukopenia as well as severely increased levels of hepatic transaminases, bilirubin, and alkaline phosphatase.[symptoma.com] Abstract Infected cell protein (ICP) 27 is an essential herpes simplex virus type 1 (HSV-1) phosphoprotein required for optimal viral DNA and early or late gene synthesis.[ncbi.nlm.nih.gov] Additionally, caspase 7 was found to be activated during HSV-1-dependent apoptosis.[ncbi.nlm.nih.gov] Also, caspase-1 was "trapped" in actin clusters at later time points that likely blocked the NLRP3/IFI16 inflammasome activity.[ncbi.nlm.nih.gov] The activation of TLR3 or TLR8 by double-stranded RNA (poly-I:C) or single-stranded RNA (ssRNA) induced IFN-alpha/beta expression.[ncbi.nlm.nih.gov]

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  • Urokinase

    Feature key Position(s) Description Actions Graphical view Length Site i 177 – 178 Cleavage; during zymogen activation 2 Keywords - PTM i Disulfide bond , Glycoprotein , Phosphoprotein[uniprot.org] Urokinase plasminogen activator (uPA) and its inhibitor plasminogen activator inhibitor-1 (PAI-1) are established independent biomarkers for high metastasis risk in breast[ncbi.nlm.nih.gov] Inactivation of protein-tyrosine phosphatase SHP-2 inhibits both basal and uPA - induced p53 expression [33] .[wikigenes.org] Urokinase plasminogen activator (uPA) system is well known for its critical roles in cancer cells invasion since uPA/uPA receptor (uPAR) overexpresses in several cancers.[ncbi.nlm.nih.gov] To determine the localization of urokinase-type plasminogen activator (u-PA), u-PA receptor (u-PAR) and α2-antiplasmin (α2AP) in the tissue of a corneal perforation, we investigated[ncbi.nlm.nih.gov]

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  • Glycogen Storage Disease

    Since the protein encoded by this gene inhibits the activity of PP1 it was once called phosphoprotein phosphatase inhibitor 1 (PPI-1) or PP1 inhibitor.[themedicalbiochemistrypage.org] activity developed HCA/HCC, while 8 did not (AAV-low-NT).[ncbi.nlm.nih.gov] Abstract Mutations in the glucose-6-phosphatase (G6Pase) gene are responsible for glycogen storage disease type Ia (GSD Ia).[ncbi.nlm.nih.gov] Glycogen storage disease type Ia (GSD-Ia) is caused by a deficiency in glucose-6-phosphatase-α (G6Pase-α or G6PC), a key enzyme in endogenous glucose production.[ncbi.nlm.nih.gov] Physical activity was evaluated by administering the International Physical Activity Questionnaire (IPAQ).[ncbi.nlm.nih.gov]

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  • Noonan Syndrome

    All PTPN11 missense mutations cluster in interacting portions of the amino N-SH2 domain and the phosphotyrosine phosphatase domains, which are involved in switching the protein[ncbi.nlm.nih.gov] Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2 . Nature 379 , 277–280 (1996). 12.[doi.org] Methods Fibrinolytic parameters including tissue plasminogen activator (t-PA; activity and antigen), plasminogen activator inhibitor type-1 (PAI-1; activity and antigen),[doi.org] NS-associated KRAS mutation resulted in Erk activation and active Ras-GTP levels, and exhibited mild cell proliferation.[ncbi.nlm.nih.gov] SHP2 is required for RAS-ERK MAP kinase (MAPK) cascade activation, and Noonan syndrome mutants enhance ERK activation ex vivo and in mice.[ncbi.nlm.nih.gov]

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  • Vasodilator

    This removal, or de-phosphorylation, is accomplished by another enzyme, a phosphatase.[diabetesincontrol.com] SUBJECTS: Wild- type and sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain-containing protein-2 knockout mice inoculated with influenza A.[ncbi.nlm.nih.gov] This study provides the first evidence of VASP manipulation by an intravacuolar bacterial pathogen via activation of PKA in human macrophages.[ncbi.nlm.nih.gov] PP2A [ 32 ], the principal phosphatase which dephosphorylates VASP [ 33 ], and at the same time activate cAMP-dependent protein kinase phosphorylation of VASP [ 6 – 9 ].[respiratory-research.biomedcentral.com] Sevoflurane (3%) only with LY294002 decreased Rho kinase activity in the rat aorta into 30%.[ncbi.nlm.nih.gov]

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