Create issue ticket

639 Possible Causes for activation, calcium, cytosol, into, ion, of, of, release, sequestered

Did you mean: amotivation, caladium, cytosol, into, ion, of, of, release, sequestered

  • Osteoporosis

    It is known that a normal calcium balance together with a normal vitamin D status is important for maintaining well-balanced bone metabolism, and for many years, calcium and[ncbi.nlm.nih.gov] This image shows typical distinguishing characteristics of an osteoclast: a large cell with multiple nuclei and a "foamy" cytosol.[emedicine.medscape.com] Abstract Promising news in the treatment of osteoporosis is that sequestering sclerostin from circulation with antibodies stimulates robust bone formation.[ncbi.nlm.nih.gov] KEYWORDS: androgen; bone; gonadotropin-releasing hormone agonists; male osteoporosis; testosterone[ncbi.nlm.nih.gov] […] between BMD and serum levels of BTMs (tartrate-resistant acid phosphatase-5b [TRAP-5b]), bone-specific alkaline phosphatase (BSAP), estradiol (E 2 ), and magnesium (Mg [2 ] ) ion[ncbi.nlm.nih.gov] Moreover, compounds 3 , 6 - 9 , and 11 significantly suppressed TRAP activities.[ncbi.nlm.nih.gov] New antiresorptive approaches are being investigated, including selective inhibitors of osteoclastic hydrogen ion transport and cathepsin K as well as antagonists to the α[dx.doi.org] The scientific information discussed in this news release related to our product candidates is preliminary and investigative.[amgen.com] […] of physical activity to overcome kinesiophobia.[ncbi.nlm.nih.gov]

    Missing: into of of
  • Catecholaminergic Polymorphic Ventricular Tachycardia

    […] beta-blockers alone since the mutations causing CPVT lead to intracellular calcium overload.[ncbi.nlm.nih.gov] However, at physiologic intracellular Ca(2 ) concentration, equivalent to the diastolic cytosolic concentration, the RyR2(R420Q) released more Ca(2 ) and oscillated faster[ncbi.nlm.nih.gov] 89 CASQ2 has a high-binding capacity (40–50 mol of Ca 2 /mol) but a moderate affinity (Kd of 1 mmol/L) for free Ca 2 and serves as molecular sink for Ca 2 that has been sequestered[doi.org] The mutation has been functionally characterized via store-overload-induced Ca(2 ) release (SOICR) and tritium-labelled ryanodine ([(3)H]ryanodine) binding assays.[ncbi.nlm.nih.gov] Stress or anxiety-induced release of endogenous catecholamines causes a dysfunction in the myocytic calcium-ion channel, leading to ventricular arrhythmias that can cause[ncbi.nlm.nih.gov] The resultant Ca(2 ) overload then randomly caused bursts of prolonged Ca(2 ) release, activating electrogenic Na( )-Ca(2 ) exchanger activity and triggering early afterdepolarizations[ncbi.nlm.nih.gov] An additional role could be played by magnesium ions (Mg 2 ) ( Fig. 2 ).[cardiovascres.oxfordjournals.org] Dantrolene reduced the number of premature ventricular complexes (PVCs) on average by 74% (range 33-97) in four patients with N-terminal or central mutations in the cytosolic[ncbi.nlm.nih.gov] S-propafenone prevented exercise-induced CPVT, whereas procainamide (20 mg/kg) or lidocaine (20 mg/kg) were ineffective (n 5 to 9 mice, P CONCLUSIONS: RyR2 cardiac Ca(2 ) release[ncbi.nlm.nih.gov]

    Missing: into of of
  • Chelating Agent

    We suggest that chitosan can be used as an effective calcium chelating agent for implants.[ncbi.nlm.nih.gov] Acid A potent competitive inhibitor of carboxypeptidase 75043-31-1 sc-206821 100 mg 250.00 0 BAPTA-APM A fluorescent Ca 2 chelator used to study the physiological role of cytosolic[scbt.com] Sequestering agents are also known as chelating agents.[chemtexlimited.com] The Pb[TCMC]2 complex was less labile to metal ion release than Pb[DOTA]2- at pH 3.5 and below in isotopic exchange experiments.[ncbi.nlm.nih.gov] A calcium ion electrode was used to measure the equilibrium calcium ion concentrations from which stability constants were calculated.[link.springer.com] The present study investigated whether desferrioxamine operates late in the activation process or, as recently suggested, at an early stage, by inhibiting the appearance of[ncbi.nlm.nih.gov] […] important role in oxidative cell damage and that this ion can enter cardiomyocytes through L-type Ca(2 ) channels, we started an iron chelating agent (deferoxamine) and a calcium[ncbi.nlm.nih.gov] To better mimic in vivo insulin release, we explored the effects of various iontophoretic current durations on dermal penetration of bpV(phen).[ncbi.nlm.nih.gov] Calcium ion was shown to play an essential role in regulating sperm molitility in semen, and EDTA was demonstrated to exert spermicidal activity by modulating calcium ion[ncbi.nlm.nih.gov]

    Missing: into of of
  • Influenza

    Children were excluded if they 1 ) had a history of stones in the urinary tract or diseases of calcium or bone metabolism, 2 ) were already taking vitamin D 3 or activated[ajcn.org] Phosphorylation of ribavirin and viramidine by adenosine kinase and cytosolic 5′‐nucleotidase II: Implications for ribavirin metabolism in erythrocytes .[ncbi.nlm.nih.gov] NS1, by virtue of its dsRNA binding properties, is likely to sequester viral dsRNA produced during viral infection, which prevents recognition of this dangerous molecule by[doi.org] […] antigens, haemagglutinin and sialidase (neuraminidase) that extensively decorate the surface of the virus and have been implicated in viral attachment and fusion, and the release[doi.org] […] of the wt ion channel protein.[doi.org] Seasonal influenza activity in the Southern Hemisphere was low overall, with influenza A(H1N1)pdm09 predominating in many regions.[ncbi.nlm.nih.gov] […] been shown to initiate apoptosis via increased ceramide in a variety of cell types. 20 21 Another factor is that toxic acyl-CoA esters accumulate within mitochondria and sequester[adc.bmjjournals.com] These findings suggest that influenza virus type A infection may have an inhibitory effect on the production or release of ACTH.[ncbi.nlm.nih.gov] Several lipoglycopeptides were also found to be active against human coronavirus. Copyright 2018 Elsevier Masson SAS. All rights reserved.[ncbi.nlm.nih.gov]

    Missing: into of of
  • Diltiazem

    The emergency physician should be aware that life-threatening tetany may accompany the administration of intravenous diltiazem and that calcium chloride may be a rapid and[ncbi.nlm.nih.gov] Cytosolic calcium in platelet activation. Experientia 1988 ; 44 : 97 –100. Hjemdahl P , Wallen NH.[pmj.bmj.com] Diltiazem is a lipophilic cardiotoxic drug, which could be sequestered in an expanded plasma lipid phase.[ncbi.nlm.nih.gov] However, no studies exist comparing oral (PO) immediate release and IV continuous infusion diltiazem in the emergency setting.[ncbi.nlm.nih.gov] […] classification [BR: br08302 ] Cardiovascular Agents Calcium Channel Blocking Agents Diltiazem D07845 Diltiazem (INN) Target-based classification of drugs [BR: br08310 ] Ion[kegg.jp] Diltiazem may suppress sympathetic activity in the hyperacute stage of aneurysmal SAH.[ncbi.nlm.nih.gov] Reactions due to diltiazem occur more frequently than with other calcium channel blockers.[ncbi.nlm.nih.gov] Diltiazem: Pharmacology Like other calcium-channel blocking agents, diltiazem inhibits the entry of calcium ions in the interior of cardiac and vascular muscle cells.[infomed.ch] The two studied complexes released the drug with different mechanism indicating two different drug/polymer interaction strengths.[ncbi.nlm.nih.gov]

    Missing: into of of
  • Calcium Channel Blocker

    Calcium channel blockers (CCB), calcium channel antagonists or calcium antagonists are several medications that disrupt the movement of calcium (Ca2 ) through calcium channels[en.wikipedia.org] Pacap increases the cytosolic Ca 2 concentration and stimulates somatodendritic vasopressin release in rat supraoptic neurons. J. Neuroendocrinol . 10, 31–42.[doi.org] ILE is theorized to sequester agents dependent on lipid solubility from the plasma, preventing further toxicity.[ncbi.nlm.nih.gov] In this report we document the effects of cessation of calcium ion channel blocker medication on male fertility.[ncbi.nlm.nih.gov] INTRODUCTION: This study examines how calcium silicate cement extracts influence the behavior of human dental pulp cells (hDPCs) through calcium channels and active mitogen-activated[ncbi.nlm.nih.gov] Ethanol increases the activity of Ca 2 -dependent K (mslo) channels: functional interaction with cytosolic Ca 2 . J Pharmacol Exp Ther 284 : 258–268, 1998 .[doi.org] Abnormal spontaneous activity in C-nociceptors functions as a marker for spontaneous pain, as reduction of this activity could indicate analgesic efficacy.[ncbi.nlm.nih.gov] A calcium channel blocker is any drug that prevents the influx of calcium ions into cardiac muscle and smooth muscle. Collins English Dictionary .[collinsdictionary.com] It is a calcium sensitizer and improves contraction without increasing intracytosolic calcium concentration. We describe two patients with serious CCB overdose.[ncbi.nlm.nih.gov]

    Missing: into of of
  • Hypomagnesemia

    Serum calcium normalized with administration of calcitriol and calcium carbonate. Serum magnesium improved with oral magnesium sulfate.[ncbi.nlm.nih.gov] Furthermore, cytosolic localization of PCBD1 increased when coexpressed with HNF1B mutants.[ncbi.nlm.nih.gov] Most is sequestered in bone and soft tissue cells, with only about 1% in the extracellular fluid. Normal plasma Mg concentration ranges from 0.70 to 1.05 mmol/L.[patient.info] Hence, PTH release is inhbited. Why PTH release increases in Mild hypomagnesemia ? Seen in magnesium level as low as 0.5 mmol/L.[epomedicine.com] Decreased levels of magnesium lead to differential conductance of K ions with more of these ions excreted in the renal tubules.[symptoma.com] Although high-dose oral Mg is reported as a sufficient therapy in most of the patients with primary familial hypomagnesemia, addition of active vitamin D to the usual oral[ncbi.nlm.nih.gov] Kelepouris E: Cytosolic Mg2 modulates whole cell K and Cl- currents in cortical thick ascending limb (TAL) cells of rabbit kidney [Abstract].[webmedcentral.com] Successful treatment included administration of calcium gluconate and magnesium both intravenously and topically.[ncbi.nlm.nih.gov] This increased cytosolic calcium concentration may be secondary to decreased activation of calcium channels, which may enhance calcium current into cells, decrease calcium[emedicine.medscape.com]

    Missing: into of of
  • Malignant Hyperthermia

    Calcium channels from Cyprinus carpio skeletal muscle.[ncbi.nlm.nih.gov] Furthermore, cells expressing these channels have an increased basal cytosolic Ca2 concentration.[en.wikipedia.org] […] as store overload-induced Ca 2 release (SOICR).[ncbi.nlm.nih.gov] As a result, large amounts of calcium ions are released from storage within muscle cells.[ghr.nlm.nih.gov] This article analyzes the activity of the Brazilian hotline service for MH in 2009.[ncbi.nlm.nih.gov] RYR1, a large ion channel, facilitates release of calcium from the sarcoplasmic reticulum into the cytosol, leading to muscle contraction by initiating cross-linking of myofilaments[dovepress.com] […] maximum activity, i.e., gain) were obtained by fitting analysis.[ncbi.nlm.nih.gov] Cytosolic dye within a small rectangular region of the expressing myotube was excited at 350 10 nm, and fluorescence emission at 405 30 nm (F 405 ) and 485 25 nm (F 485 )[doi.org] All swine and up to 50% of human MH events are thought to be associated with mutations in the calcium release channel of the sarcoplasmic reticulum, also known as the ryanodine[ncbi.nlm.nih.gov]

    Missing: into of of
  • Catecholaminergic Polymorphic Ventricular Tachycardia 1

    These regulate the release of calcium ions into the rest of the cell.[myheart.org.uk] Many of these CPVT-associated RyR2 mutations enhance the propensity for SOICR and DADs by sensitizing RyR2 to luminal or luminal/cytosolic Ca 2 activation.[biochemj.org] […] calcium ion [ IC , ISS ] regulation of heart rate [ IMP ] release of sequestered calcium ion into cytosol [ IDA , ISS ] release of sequestered calcium ion into cytosol by[thebiogrid.org] The channels can be activated by EMD to varying degrees as shown by their respective open probabilities (Po).[nature.com] 26 (76.5%) Non-physical activity 20 (58.8%) Emotional stress 12 (35.3%) Normal activity 12 (35.3%) Probands with 3 cardiac events before diagnosis 20 (62.5%) Parameters on[jstage.jst.go.jp] […] calcium ion into cytosol] GO:0051284 [positive regulation of sequestering of calcium ion] GO:0051480 [regulation of cytosolic calcium ion concentration] GO:0051775 [response[proteinatlas.org] […] polymorphic ventricular tachycardia is a rare condition mainly associated with two genes that make proteins found inside the cell – the human ryanodine receptor (a calcium ion[c-r-y.org.uk] Mutations in RYR2 and CASQ2 lead to uncontrolled calcium ion leakage from the sarcoplasmic reticulum to the cytosol that worsen on adrenergic stimulation increasing the susceptibility[cohesionphenomics.com] Catecholaminergic Polymorphic Ventricular Tachycardia is caused by an abnormality in the heart's ion channels (proteins that control the passage of important chemicals such[uwhealth.org]

    Missing: into of of
  • Neuromuscular Junction Disorder

    […] through voltage gated calcium channels.[en.wikipedia.org] Endocytosis Translocation of toxin into cytosol Inhibtion of the VAMP complex (Essential for synaptic vessicle fusion) 7. 8. 25. Tetanus.[slideshare.net] This calcium, which is normally sequestered in the sarcoplasmic reticulum, couples excitation to the interaction between myofilaments that shorten the fiber.[dartmouth.edu] In a resting state, there is a random release of ACh from a single vesicle.[what-when-how.com] Part two then addresses the complete range of specific neuromuscular diseases: neuronopathies, peripheral neuropathies, neuromuscular junction disorders, muscle ion channel[books.google.com] Some neuromuscular junction disorders decrease the nerve's activity, causing weakness.[merckmanuals.com] […] the arrival of an action potential at the axon terminal, voltage-dependent calcium channels open and Ca 2 ions flow from the extracellular fluid into the motor neuron's cytosol[psychology.wikia.com] The influx of calcium ions results in an increased probability of additional release of ACh for a short time ( 18 ).[musculoskeletalkey.com] SYT2 is present at the pre-synaptic terminal, the end of the nerve cell that sits at the neuromuscular junction and helps the cells sense fluctuations in calcium levels.[urmc.rochester.edu]

    Missing: into of of