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184 Possible Causes for activation, cascade, kinin, of

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  • Influenza

    ., kinins) in nasal secretions, which results in symptomatic illness.[doi.org] Seasonal influenza activity in the Southern Hemisphere was low overall, with influenza A(H1N1)pdm09 predominating in many regions.[ncbi.nlm.nih.gov] Most cells have intracellular sensors of viral products that, when activated, initiate a signaling cascade that results in transcriptional induction of the IFNβ gene.[doi.org] Nationally, ILI activity began increasing in November, reaching an extended period of high activity during January-February, and remaining elevated through March.[ncbi.nlm.nih.gov]

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  • Hereditary Angioedema Type 3

    […] esterase inhibitor (C1-INH) is a protease inhibitor that blocks the activation of the classic complement pathway, but there are also many others biochemical pathways, including kinin[signavitae.com] It is associated with mutations in the gene for FACTOR XII that result in its increased activity.[wap.doctor.am] Factor XII considered as the key element in the coagulation cascade.[symptoma.com] .: The intrinsic coagulation/kinin-forming cascade: assembly in plasma and cell surfaces in inflammation . Adv Immunol 1997, 66: 225–272.[link.springer.com]

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  • Factor XII Deficiency

    Detailed investigations for the intrinsic and extrinsic pathways of coagulation, fibrinolytic system, kinin-kallikrein system, and complement system were performed because[ncbi.nlm.nih.gov] Factor XII is a plasma protein that is involved in the initiation of the intrinsic coagulation cascade.[symptoma.com] Factor XII plays a central role in the intrinsic activation of fibrinolysis and consequently the defective intrinsic fibrinolytic activity detected in the present case casts[ncbi.nlm.nih.gov] […] not only has an important function in the initiation of the intrinsic pathway of the coagulation cascade, but it also plays a significant role in complement activation, kinin[ncbi.nlm.nih.gov]

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  • Hereditary Angioedema

    […] techniques used to isolate and purify human-derived C1 inhibitor, the production of a recombinant form of C1 inhibitor, and the development of drugs that target the kallikrein-kinin[ncbi.nlm.nih.gov] Plasma kallikrein plays a major role in the contact (kallikrein-kinin) cascade producing bradykinin.[ncbi.nlm.nih.gov] It has been suggested that measurement of C4 activation products is better suited to avoid false negative results.[ncbi.nlm.nih.gov] Plasma kallikrein is also crosslinked to the coagulation system and the complement cascade.[doi.org]

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  • Acute Inflammation

    […] system Definition *fibrinolytic and coagulative systems - see hemostasis notes 1.Kinin System: -kinins are polypeptides activated via the cascade system (hemostasis notes[flashcardmachine.com] Previous studies on EGC pathophysiology have specifically focused on mucosal glia activation and its contribution to mucosal inflammatory processes observed in the gut of[ncbi.nlm.nih.gov] Inflammatory responses, like all biological cascades, are shaped by a delicate balance between positive and negative feedback loops.[ncbi.nlm.nih.gov] Physical activity does not provide protection against these inflammation-induced changes.[ncbi.nlm.nih.gov]

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  • Hereditary Angioedema Type 1

    […] esterase inhibitor (C1-INH) is a protease inhibitor that blocks the activation of the classic complement pathway, but there are also many others biochemical pathways, including kinin[signavitae.com] Cichon S. et al., Increased activity of coagulation factor XII (Hageman factor) causes hereditary angioedema type III. Am J Hum Genet. 2006 Dec;79(6):1098-104.[genedx.com] This cascade causes another protein called plasma kallikrein to trigger the release of a third protein called bradykinin.[firazyr.com] Deficiency of C1 inhibitor therefore results in unregulated activation of the classical complement pathway and of the kinin-generating system.[clinicaladvisor.com]

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  • Hereditary Angioedema Type 2

    […] esterase inhibitor (C1-INH) is a protease inhibitor that blocks the activation of the classic complement pathway, but there are also many others biochemical pathways, including kinin[signavitae.com] The diagnosis is made after conducting blood tests to assess the levels of C1-INH and its functional activity.[symptoma.com] Hereditary angioedema (HAE) attacks involve the activation of the contact, complement, and fibrinolytic plasma proteolytic cascades.[jaoa.org] Deficiency of C1 inhibitor therefore results in unregulated activation of the classical complement pathway and of the kinin-generating system.[clinicaladvisor.com]

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  • Disseminated Intravascular Coagulation

    The excess plasmin also activates the complement and kinin systems.[en.wikipedia.org] Plasma ADAMTS-13 activity determined at diagnosis of DIC may help predict the risk of hemorrhagic events during and/or following DIC treatment with hematologic disorders.[ncbi.nlm.nih.gov] The close connection between endothelium and superimposed immuno-modulators is stressed as is the interrelation between the proteolytic cascade systems in the blood.[ncbi.nlm.nih.gov] English disseminated intravascular coagulation pathological process characterized by the widespread activation of the clotting cascade that results in the formation of blood[wikidata.org]

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  • Hemophilia A

    The activation of factor XII can also initiate the extrinsic pathway, fibrinolysis, kinin generation, and complement activation.[emedicine.medscape.com] Abstract This study investigated the disposition of coagulation factor VIII activity in 754 patients with moderate to severe hemophilia A following the administration of moroctocog[ncbi.nlm.nih.gov] Hypothermia and activation of the inflammatory cascade also affect coagulation. The effects of CPB on circulating levels of factor VIII have not been clearly defined.[ncbi.nlm.nih.gov] Approximately, 1 in 3 patients with severe hemophilia A produce neutralizing antibodies (inhibitors) that block its biologic function in the clotting cascade.[ncbi.nlm.nih.gov]

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  • Acquired Angioedema

    In this way unregulated activation of the kinin and complement pathways occurs, leading to disease manifestations via as yet uncharacterized mediators.[ncbi.nlm.nih.gov] OBJECTIVE: To evaluate whether activated partial thromboplastin time (APTT) could be used in the laboratory diagnosis of hereditary or acquired angioedema (HAE or AAE) with[ncbi.nlm.nih.gov] The 3 known pathways of this cascade are the classic, 6 alternative, and lectin-or mannan-binding pathway.[mdmag.com] […] system kinase kinin receptor kininogen kinins Kojda G Kreuz laryngeal edema long-term prophylaxis mediated mice mutation Nussberger patients with hereditary pd Cl-INH peptide[books.google.com]

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