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3,663 Possible Causes for activation, cell, determination, fate, Intermediate, mesodermal, of

Did you mean: amotivation, cell, determination, fate, Intermediate, mesodermal, of

  • Myelofibrosis

    […] tissue, fibroblasts are derived from primitive mesenchyme, thus they express the intermediate filament protein vimentin, a feature used as a marker to distinguish their mesodermal[wikivisually.com] Haematopoietic cell-fate decisions, chromatin regulation and ikaros. Nat Rev Immunol. 2002;2:162–74. PubMed CrossRef Google Scholar 43.[doi.org] KEYWORDS: IPSS; MF; intermediate-1 risk; myelofibrosis; ruxolitinib[ncbi.nlm.nih.gov] However, optimal dose and tapering schedule of ruxolitinib remain to be determined.[ncbi.nlm.nih.gov] Also in Gata1 low mice activation of the TPO/MPL axis was associated with a RSP14 deficiency and a discordant microarray ribosome signature (reduced RPS24, RPS26 and SBDS[ncbi.nlm.nih.gov] Current strategies for stem cell therapy Stem cell transplantation can be performed with either autologous or allogeneic (syngeneic) stem cells.[doi.org] In this study, we aimed primarily to evaluate the detailed results of bone marrow (BM) biopsies of SLE patients, secondly to determine the myelofibrosis (MF) frequency and[ncbi.nlm.nih.gov]

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  • Influenza

    Overall, our work suggests that experimental measurements of mutational effects can be leveraged to help understand the evolutionary fates of viral lineages in nature-but[ncbi.nlm.nih.gov] Potentially, this may be an example of the adaptation of avian viruses to mammals, which would represent an intermediate step in the evolution of new mammalian strains.[pubmedcentral.nih.gov] We studied an outbreak of A(H1N1) influenza in an Israeli military unit of 336 healthy young men to determine the relation of cigarette smoking to the incidence of clinically[ncbi.nlm.nih.gov] Seasonal influenza activity in the Southern Hemisphere was low overall, with influenza A(H1N1)pdm09 predominating in many regions.[ncbi.nlm.nih.gov] METHODS: We applied cell mixture deconvolution to estimate immune cell proportions from whole blood transcriptome data in four independent influenza challenge studies.[ncbi.nlm.nih.gov] Since intracellular signaling pathways represent key switches in the determination of cell fate, the knowledge about their activation and function in infected cells may help[horizonpress.com] At an intermediate RH of 50%, however, only one of four naïve animals contracted infection.[dx.doi.org]

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  • Embryonal Carcinoma

    […] others have previously demonstrated that inhibition of ROCK blocks endoderm differentiation in embryonal carcinoma stem cells, however, the effect of ROCK inhibition on mesoderm[ncbi.nlm.nih.gov] This study demonstrates an important role of Beclin-1 and p53 interaction in cell fate decision of human embryonal carcinoma cells.[ncbi.nlm.nih.gov] At the ultrastructural level three cell types were noted: undifferentiated, differentiated, and intermediate types.[ncbi.nlm.nih.gov] It can be flexibly applied to determine the contents of the classical transmitters in other biological matrix samples with minor changes. Copyright 2014.[ncbi.nlm.nih.gov] Cisplatin and fisetin as single agents activated caspases-8 and -3 and caspases-9 and -7, respectively, whereas combination treatment activated all 4 caspases.[ncbi.nlm.nih.gov] Human embryonal carcinoma cells (ECCs), stem cells of human teratocarcinomas, are considered a close but malignant counterpart to human ESCs.[ncbi.nlm.nih.gov] The secretor and Lewis gene typings, which affect the normal serum ranges of CA19-9 and DU-PAN-2, were determined.[ncbi.nlm.nih.gov]

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  • Bacillus Thuringiensis

    […] dorsal–ventral polarity are attached to the chorion and released into the perivitelline egg space, whereas immune elicitors may be stored in the yolk interacting with primordial mesodermal[pnas.org] Keywords: Environmental fate; Bt proteins; transgenic crops; nontarget effects; Cry protein[doi.org] Further work is needed to determine the role of Cry-receptor molecules in mosquitoes and if a pre-pore oligomeric structure is also a membrane-insertion intermediate in these[ncbi.nlm.nih.gov] Kd for MCF-7 was not determined as the inhibitory concentration (IC50) was not reached.[ncbi.nlm.nih.gov] Solubilized protoxins are activated by midgut proteases and bind to receptors on the epithelial surface.[doi.org] This study determines the efficacy and mode of cell death of Bt 18 parasporal proteins against 3 leukemic cell lines (CEM-SS, CCRF-SB and CCRF-HSB-2).Cell-based biochemical[ncbi.nlm.nih.gov] This paper reviews the scientific literature addressing the environmental fate and nontarget effects of the Cry protein toxins from Bacillus thuringiensis (Bt), specifically[ncbi.nlm.nih.gov]

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  • Idiopathic Pulmonary Fibrosis

    Tgfβ2 and 3 are coexpressed with their extracellular regulator Ltbp1in the early limb bud and modulate mesodermal outgrowth and BMP signaling in chicken embryos.[nature.com] According to Lopez-Otin and Bond proteases (a) regulate the fate, localization and activity of many proteins, b) modulate protein-protein interactions, c) create new bioactive[newswithviews.com] Lung fibrocytes have different characteristics than circulating fibrocytes and represent an intermediate cell population between circulating fibrocytes and lung fibroblast[ncbi.nlm.nih.gov] Death registrations and primary care data were used to determine the current trends in IPF incidence in the U.K.[ncbi.nlm.nih.gov] Physical activity was assessed using a physical activity monitor.[ncbi.nlm.nih.gov] Keywords: Embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, pulmonary fibrosis, treatment.[doi.org] Mean change in percentage FVC in the pirfenidone 1197 mg/day group was intermediate to that in the pirfenidone 2403 mg/day and placebo groups.[ncbi.nlm.nih.gov]

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  • T-cell Acute Lymphoblastic Leukemia

    Leukemia (1997) [ Pubmed ] VEGF directs newly gastrulated mesoderm to the endothelial lineage.[wikigenes.org] The NOTCH family of protein transmembrane receptors are crucial for regulation of apoptosis, cell proliferation and their fate during development.[symptoma.com] Analysis of 5'-capped RNA transcripts in mutant cell lines identified the usage of an intermediate promoter site, with consequential monoallelic LMO2 overexpression.[ncbi.nlm.nih.gov] The in vitro experiments demonstrated that miR-101 significantly repressed the proliferation and invasion, and induced potent apoptosis in Jurkat cells, as determined by CCK[ncbi.nlm.nih.gov] We also identified evidence of NOTCH3 activation in 12 of 24 patient-derived orthotopic xenograft models, 2 of which exhibit activation of NOTCH3 without activation of NOTCH1[ncbi.nlm.nih.gov] […] an increase of mitochondrial respiration for cell survival.[ncbi.nlm.nih.gov] Coherently, modulation of Cn activity in T-ALL cells determined alterations in the phosphorylation status of key molecules implicated in protein translation such as eIF-2α[ncbi.nlm.nih.gov]

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  • B-Precursor Acute Lymphoblastic Leukemia

    Perturbations of the TGF-ß/bone morphogenetic protein/SKI oncogene pathway involved in early mesoderm development are unique to this cluster and may provide new insights into[ufrgs.br] Fates of human B-cell precursors. Blood . 96 , (1), 9-23 (2000). Schmid, I., et al.[jove.com] Major sex differences in EFS were observed in older children (10 to 22 years), in patients with intermediate WBC counts (10 to 50 x 10(9)/ L), and in children who fit both[ncbi.nlm.nih.gov] Abstract To determine whether the ALL (acute lymphoblastic leukemia) CDR3 (third complementarity-determining region) repertoire represents the recombination repertoire, or[ncbi.nlm.nih.gov] Activation of Akt reduced the extent of apoptosis induced by the antitumor drugs in Nalm-6 listed above.[ncbi.nlm.nih.gov] HTLV-1 ( Adult T-cell leukemia/lymphoma ) NK cell / (most CD56 ) Aggressive NK-cell leukemia Blastic NK cell lymphoma T or NK EBV ( Extranodal NK-T-cell lymphoma / Angiocentric[en.wikipedia.org] However, intermediate cytogenetic risk patients, separated into two subgroups (good risk vs . intermediate-/high-risk CNA profile) with differential OS rates (98% vs . 87%[haematologica.org]

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  • Cytotoxic Agent

    HT-1080, a fibrosarcoma cell line, and HS-42, a malignant mesodermal cell line, were the most sensitive of the cell lines to methotrexate, doxorubicin, etoposide, and paclitaxel[ncbi.nlm.nih.gov] Cell physiology [ edit ] Treating cells with the cytotoxic compound can result in a variety of cell fates.[en.wikipedia.org] Abstract Transarterial chemoembolization (TACE) is the main treatment for intermediate stage hepatocellular carcinoma (HCC) with Barcelona Clinic Liver Cancer classification[ncbi.nlm.nih.gov] Abstract Most phase I clinical trials are designed to determine a maximum-tolerated dose (MTD) for one initial administration or treatment course of a cytotoxic experimental[ncbi.nlm.nih.gov] Abstract The diarylsulfonylureas (DSUs) are a novel class of cytotoxic agents with high potential for activity. LY295501 is one of the most active DSUs.[ncbi.nlm.nih.gov] Moreover, Apt-Dox retained the efficacy of doxorubicin against MUC1-positive tumor cells, but lowered the toxicity to MUC1-negative cells (P[ncbi.nlm.nih.gov] Resolution of this covalent intermediate depends on the abstraction of a hydrogen atom from position 5 of uracil (highlighted in red).[watcut.uwaterloo.ca]

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  • Epithelioid Cell Sarcoma

    […] the large cell, rhabdoid, or proximal variant. 20 Histogenetical and immunohistochemical studies discuss relations to fibroblasts, histiocytes, synovial cells, primitive mesoderm-related[nature.com] In contrast, exogenous pyruvate may have a different metabolic fate than pyruvate generated via glycolysis.[doi.org] Seven tumors were investigated at the ultrastructural level, four of which showed prominent intracytoplasmic intermediate filament aggregates, often accumulating into paranuclear[ncbi.nlm.nih.gov] Thus, the benefit of targeted therapy against EGFR in patients with epithelioid sarcoma remains to be determined.[ncbi.nlm.nih.gov] Here, we describe broad-spectrum activity, hypoxia-selective activation, and mechanism of action of TH-302.[doi.org] In the present study, we established a new human ES cell line (ESX) and analyzed the characteristics of its cancer stem-like cells/cancer-initiating cells (CSCs/CICs) based[ncbi.nlm.nih.gov] Etiology [ edit ] Arise from primitive mesenchyme of the mesoderm, which gives rise to muscle, fat, fibrous tissues, blood vessels, and supporting cells of the peripheral[en.wikibooks.org]

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  • Rhabdomyosarcoma

    Embryonic origin RMS is postulated to be derived from mesodermal tissues.[atlasgeneticsoncology.org] RMS with diffuse anaplasia (2% of all RMS) has a poor prognosis (45% 5-year survival). 17 The fate of RMS with focal anaplasia (2% of RMS) is less clear.[ncbi.nlm.nih.gov] Kaplan-Meier and Cox proportional hazard regression models were used to determine the demographic characteristics, prognostic factors, and treatment modalities that determine[ncbi.nlm.nih.gov] Benth (Leguminosae) exhibited significant cytotoxic activity against the RD cell line and had comparable lethal activity on the brine shrimps.[ncbi.nlm.nih.gov] The inhibition of extracellular regulated kinases (ERK) pathway prevented ferroptosis in U57810 and C2C12 cells, whereas its increased activation in the embryonal RD cells[ncbi.nlm.nih.gov] These two genes are thought to be important in muscle development during embryogenesis, when condensations of mesoderm known as somites are formed from which skeletal muscle[adc.bmj.com] […] are expressed at unusually high concentrations and are able to bind a majority of enhancers are defined as master transcription factors (MTF) and key determinants of cell fate[cancerdiscovery.aacrjournals.org]

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