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3,663 Possible Causes for activation, cell, determination, fate, Intermediate, mesodermal, of

Did you mean: amotivation, cell, determination, fate, Intermediate, mesodermal, of

  • Myelofibrosis

    […] tissue, fibroblasts are derived from primitive mesenchyme, thus they express the intermediate filament protein vimentin, a feature used as a marker to distinguish their mesodermal[] Haematopoietic cell-fate decisions, chromatin regulation and ikaros. Nat Rev Immunol. 2002;2:162–74. PubMed CrossRef Google Scholar 43.[] KEYWORDS: IPSS; MF; intermediate-1 risk; myelofibrosis; ruxolitinib[] However, optimal dose and tapering schedule of ruxolitinib remain to be determined.[] Also in Gata1 low mice activation of the TPO/MPL axis was associated with a RSP14 deficiency and a discordant microarray ribosome signature (reduced RPS24, RPS26 and SBDS[] Current strategies for stem cell therapy Stem cell transplantation can be performed with either autologous or allogeneic (syngeneic) stem cells.[] In this study, we aimed primarily to evaluate the detailed results of bone marrow (BM) biopsies of SLE patients, secondly to determine the myelofibrosis (MF) frequency and[]

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  • Influenza

    Overall, our work suggests that experimental measurements of mutational effects can be leveraged to help understand the evolutionary fates of viral lineages in nature-but[] Potentially, this may be an example of the adaptation of avian viruses to mammals, which would represent an intermediate step in the evolution of new mammalian strains.[] We studied an outbreak of A(H1N1) influenza in an Israeli military unit of 336 healthy young men to determine the relation of cigarette smoking to the incidence of clinically[] Seasonal influenza activity in the Southern Hemisphere was low overall, with influenza A(H1N1)pdm09 predominating in many regions.[] METHODS: We applied cell mixture deconvolution to estimate immune cell proportions from whole blood transcriptome data in four independent influenza challenge studies.[] Since intracellular signaling pathways represent key switches in the determination of cell fate, the knowledge about their activation and function in infected cells may help[] At an intermediate RH of 50%, however, only one of four naïve animals contracted infection.[]

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  • Embryonal Carcinoma

    […] others have previously demonstrated that inhibition of ROCK blocks endoderm differentiation in embryonal carcinoma stem cells, however, the effect of ROCK inhibition on mesoderm[] This study demonstrates an important role of Beclin-1 and p53 interaction in cell fate decision of human embryonal carcinoma cells.[] At the ultrastructural level three cell types were noted: undifferentiated, differentiated, and intermediate types.[] It can be flexibly applied to determine the contents of the classical transmitters in other biological matrix samples with minor changes. Copyright 2014.[] Cisplatin and fisetin as single agents activated caspases-8 and -3 and caspases-9 and -7, respectively, whereas combination treatment activated all 4 caspases.[] Human embryonal carcinoma cells (ECCs), stem cells of human teratocarcinomas, are considered a close but malignant counterpart to human ESCs.[] The secretor and Lewis gene typings, which affect the normal serum ranges of CA19-9 and DU-PAN-2, were determined.[]

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  • Bacillus Thuringiensis

    […] dorsal–ventral polarity are attached to the chorion and released into the perivitelline egg space, whereas immune elicitors may be stored in the yolk interacting with primordial mesodermal[] Keywords: Environmental fate; Bt proteins; transgenic crops; nontarget effects; Cry protein[] Further work is needed to determine the role of Cry-receptor molecules in mosquitoes and if a pre-pore oligomeric structure is also a membrane-insertion intermediate in these[] Kd for MCF-7 was not determined as the inhibitory concentration (IC50) was not reached.[] Solubilized protoxins are activated by midgut proteases and bind to receptors on the epithelial surface.[] This study determines the efficacy and mode of cell death of Bt 18 parasporal proteins against 3 leukemic cell lines (CEM-SS, CCRF-SB and CCRF-HSB-2).Cell-based biochemical[] This paper reviews the scientific literature addressing the environmental fate and nontarget effects of the Cry protein toxins from Bacillus thuringiensis (Bt), specifically[]

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  • Idiopathic Pulmonary Fibrosis

    Tgfβ2 and 3 are coexpressed with their extracellular regulator Ltbp1in the early limb bud and modulate mesodermal outgrowth and BMP signaling in chicken embryos.[] According to Lopez-Otin and Bond proteases (a) regulate the fate, localization and activity of many proteins, b) modulate protein-protein interactions, c) create new bioactive[] Lung fibrocytes have different characteristics than circulating fibrocytes and represent an intermediate cell population between circulating fibrocytes and lung fibroblast[] Death registrations and primary care data were used to determine the current trends in IPF incidence in the U.K.[] Physical activity was assessed using a physical activity monitor.[] Keywords: Embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, pulmonary fibrosis, treatment.[] Mean change in percentage FVC in the pirfenidone 1197 mg/day group was intermediate to that in the pirfenidone 2403 mg/day and placebo groups.[]

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  • T-cell Acute Lymphoblastic Leukemia

    Leukemia (1997) [ Pubmed ] VEGF directs newly gastrulated mesoderm to the endothelial lineage.[] The NOTCH family of protein transmembrane receptors are crucial for regulation of apoptosis, cell proliferation and their fate during development.[] Analysis of 5'-capped RNA transcripts in mutant cell lines identified the usage of an intermediate promoter site, with consequential monoallelic LMO2 overexpression.[] The in vitro experiments demonstrated that miR-101 significantly repressed the proliferation and invasion, and induced potent apoptosis in Jurkat cells, as determined by CCK[] We also identified evidence of NOTCH3 activation in 12 of 24 patient-derived orthotopic xenograft models, 2 of which exhibit activation of NOTCH3 without activation of NOTCH1[] […] an increase of mitochondrial respiration for cell survival.[] Coherently, modulation of Cn activity in T-ALL cells determined alterations in the phosphorylation status of key molecules implicated in protein translation such as eIF-2α[]

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  • B-Precursor Acute Lymphoblastic Leukemia

    Perturbations of the TGF-ß/bone morphogenetic protein/SKI oncogene pathway involved in early mesoderm development are unique to this cluster and may provide new insights into[] Fates of human B-cell precursors. Blood . 96 , (1), 9-23 (2000). Schmid, I., et al.[] Major sex differences in EFS were observed in older children (10 to 22 years), in patients with intermediate WBC counts (10 to 50 x 10(9)/ L), and in children who fit both[] Abstract To determine whether the ALL (acute lymphoblastic leukemia) CDR3 (third complementarity-determining region) repertoire represents the recombination repertoire, or[] Activation of Akt reduced the extent of apoptosis induced by the antitumor drugs in Nalm-6 listed above.[] HTLV-1 ( Adult T-cell leukemia/lymphoma ) NK cell / (most CD56 ) Aggressive NK-cell leukemia Blastic NK cell lymphoma T or NK EBV ( Extranodal NK-T-cell lymphoma / Angiocentric[] However, intermediate cytogenetic risk patients, separated into two subgroups (good risk vs . intermediate-/high-risk CNA profile) with differential OS rates (98% vs . 87%[]

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  • Cytotoxic Agent

    HT-1080, a fibrosarcoma cell line, and HS-42, a malignant mesodermal cell line, were the most sensitive of the cell lines to methotrexate, doxorubicin, etoposide, and paclitaxel[] Cell physiology [ edit ] Treating cells with the cytotoxic compound can result in a variety of cell fates.[] Abstract Transarterial chemoembolization (TACE) is the main treatment for intermediate stage hepatocellular carcinoma (HCC) with Barcelona Clinic Liver Cancer classification[] Abstract Most phase I clinical trials are designed to determine a maximum-tolerated dose (MTD) for one initial administration or treatment course of a cytotoxic experimental[] Abstract The diarylsulfonylureas (DSUs) are a novel class of cytotoxic agents with high potential for activity. LY295501 is one of the most active DSUs.[] Moreover, Apt-Dox retained the efficacy of doxorubicin against MUC1-positive tumor cells, but lowered the toxicity to MUC1-negative cells (P[] Resolution of this covalent intermediate depends on the abstraction of a hydrogen atom from position 5 of uracil (highlighted in red).[]

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  • Epithelioid Cell Sarcoma

    […] the large cell, rhabdoid, or proximal variant. 20 Histogenetical and immunohistochemical studies discuss relations to fibroblasts, histiocytes, synovial cells, primitive mesoderm-related[] In contrast, exogenous pyruvate may have a different metabolic fate than pyruvate generated via glycolysis.[] Seven tumors were investigated at the ultrastructural level, four of which showed prominent intracytoplasmic intermediate filament aggregates, often accumulating into paranuclear[] Thus, the benefit of targeted therapy against EGFR in patients with epithelioid sarcoma remains to be determined.[] Here, we describe broad-spectrum activity, hypoxia-selective activation, and mechanism of action of TH-302.[] In the present study, we established a new human ES cell line (ESX) and analyzed the characteristics of its cancer stem-like cells/cancer-initiating cells (CSCs/CICs) based[] Etiology [ edit ] Arise from primitive mesenchyme of the mesoderm, which gives rise to muscle, fat, fibrous tissues, blood vessels, and supporting cells of the peripheral[]

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  • Rhabdomyosarcoma

    Embryonic origin RMS is postulated to be derived from mesodermal tissues.[] RMS with diffuse anaplasia (2% of all RMS) has a poor prognosis (45% 5-year survival). 17 The fate of RMS with focal anaplasia (2% of RMS) is less clear.[] Kaplan-Meier and Cox proportional hazard regression models were used to determine the demographic characteristics, prognostic factors, and treatment modalities that determine[] Benth (Leguminosae) exhibited significant cytotoxic activity against the RD cell line and had comparable lethal activity on the brine shrimps.[] The inhibition of extracellular regulated kinases (ERK) pathway prevented ferroptosis in U57810 and C2C12 cells, whereas its increased activation in the embryonal RD cells[] These two genes are thought to be important in muscle development during embryogenesis, when condensations of mesoderm known as somites are formed from which skeletal muscle[] […] are expressed at unusually high concentrations and are able to bind a majority of enhancers are defined as master transcription factors (MTF) and key determinants of cell fate[]

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