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3,370 Possible Causes for activation, cell, fate, lateral, mesodermal, of, specification

Did you mean: amotivation, cell, fate, lateral, mesodermal, of, specification

  • Influenza

    Overall, our work suggests that experimental measurements of mutational effects can be leveraged to help understand the evolutionary fates of viral lineages in nature-but[ncbi.nlm.nih.gov] PR8HA-specific IgG1 and IgG2a antibodies were detected by ELISA.[doi.org] Seasonal influenza activity in the Southern Hemisphere was low overall, with influenza A(H1N1)pdm09 predominating in many regions.[ncbi.nlm.nih.gov] METHODS: We applied cell mixture deconvolution to estimate immune cell proportions from whole blood transcriptome data in four independent influenza challenge studies.[ncbi.nlm.nih.gov] She was discharged 2 days later on a tapering dose of steroids. BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2018. All rights reserved.[ncbi.nlm.nih.gov] Since intracellular signaling pathways represent key switches in the determination of cell fate, the knowledge about their activation and function in infected cells may help[horizonpress.com] Thirty-seven years later, this goal has not yet been achieved.[doi.org]

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  • Embryonal Carcinoma

    […] others have previously demonstrated that inhibition of ROCK blocks endoderm differentiation in embryonal carcinoma stem cells, however, the effect of ROCK inhibition on mesoderm[ncbi.nlm.nih.gov] This study demonstrates an important role of Beclin-1 and p53 interaction in cell fate decision of human embryonal carcinoma cells.[ncbi.nlm.nih.gov] Cisplatin and fisetin as single agents activated caspases-8 and -3 and caspases-9 and -7, respectively, whereas combination treatment activated all 4 caspases.[ncbi.nlm.nih.gov] Human embryonal carcinoma cells (ECCs), stem cells of human teratocarcinomas, are considered a close but malignant counterpart to human ESCs.[ncbi.nlm.nih.gov] He died four weeks later due to pneumonia and respiratory failure.[ncbi.nlm.nih.gov] Abstract 28-year-old sportsman developed chest pain, dyspnoea, haemoptysis and swelling of the right leg. 8 weeks later he also complained of blurred vision.[ncbi.nlm.nih.gov] Xenografting of SOX2-deficient cells into the flank of nude mice resulted in maintenance of a seminoma-like fate, indicated by the histology and expression of OCT3/4, SOX17[ncbi.nlm.nih.gov]

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  • Bacillus Thuringiensis

    […] dorsal–ventral polarity are attached to the chorion and released into the perivitelline egg space, whereas immune elicitors may be stored in the yolk interacting with primordial mesodermal[pnas.org] Keywords: Environmental fate; Bt proteins; transgenic crops; nontarget effects; Cry protein[doi.org] In return, you can help by: sending us reprints of your publications making available your unpublished toxin specificity data: please use the Toxin specificity information[web.archive.org] Solubilized protoxins are activated by midgut proteases and bind to receptors on the epithelial surface.[doi.org] This study determines the efficacy and mode of cell death of Bt 18 parasporal proteins against 3 leukemic cell lines (CEM-SS, CCRF-SB and CCRF-HSB-2).Cell-based biochemical[ncbi.nlm.nih.gov] The proportion of third and fourth instars on the control diet also increased initially, with an equilibrium occurring 12 to 24 h later when 30 to 40% of larvae were found[doi.org] Ishiwatari had named the bacterium Bacillus sotto in 1901 but the name was later ruled invalid.[bt.ucsd.edu]

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  • Inflammation

    Failure of extraembryonic membrane formation and mesoderm induction in embryos lacking the tumor suppressor Smad2 . Proc. Natl Acad. Sci. USA 95 , 9378–9383 (1998). 9.[doi.org] Some of those proteins interact with the glucocorticoid receptor and other factors essential to cell fate.[doi.org] Finally, the AMP-activated protein kinase (AMPK) and its downstream S6 kinase (S6K) were detected in CSE-stimulated BECs.[ncbi.nlm.nih.gov] Tryptases and chymases are the major proteins stored and secreted by mast cells.[ncbi.nlm.nih.gov] An early loss of gut mucosal integrity, the pro-inflammatory cytokine milieu, co-infections and later, marked destruction of lymph node architecture are all factors contributing[ncbi.nlm.nih.gov] Ectopic Pax-3 activates MyoD and Myf-5 expression in embryonic mesoderm and neural tissue.[doi.org] In vivo fate of the inflammatory macrophage during the resolution of inflammation: Inflammatory macrophages do not die locally but emigrate to the draining lymph nodes .[doi.org]

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  • Werner Syndrome

    Abstract Werner syndrome (WS) is a premature aging disorder that mainly affects tissues derived from mesoderm.[ncbi.nlm.nih.gov] Since the fate of the 15mer product could eventually be either SN or LP BER, quantification of this product was not included (see below).[doi.org] The cause of this lineage-specific aging remains unknown.[ncbi.nlm.nih.gov] Ascorbate supplementation of WRN-depleted cells led to a dose-dependent inhibition of HIF-1 activation.[ncbi.nlm.nih.gov] Here, we report on the generation of a human WS model in human embryonic stem cells (ESCs).[ncbi.nlm.nih.gov] Ten months later, the right convexity tumor was removed because follow-up MR imaging detected tumor growth. The histological diagnosis was transitional meningioma.[ncbi.nlm.nih.gov] Rad51 foci were also elevated in FA-D2(-/-) cells exposed to NSC 617145 and mitomycin C, suggesting that WRN helicase inhibition interferes with later steps of homologous[ncbi.nlm.nih.gov]

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  • Rhabdomyosarcoma

    Embryonic origin RMS is postulated to be derived from mesodermal tissues.[atlasgeneticsoncology.org] […] are expressed at unusually high concentrations and are able to bind a majority of enhancers are defined as master transcription factors (MTF) and key determinants of cell fate[doi.org] […] and are more specific than desmin and muscle-specific actin and more sensitive than myoglobin.[doi.org] Benth (Leguminosae) exhibited significant cytotoxic activity against the RD cell line and had comparable lethal activity on the brine shrimps.[ncbi.nlm.nih.gov] The inhibition of extracellular regulated kinases (ERK) pathway prevented ferroptosis in U57810 and C2C12 cells, whereas its increased activation in the embryonal RD cells[ncbi.nlm.nih.gov] Two years later, liver metastasis in the left and right lobes was found and was followed by VAC chemotherapy (CTX, 1800 mg; Act-D, 0.9 mg; VCR, 1.2 mg), with no change of[ncbi.nlm.nih.gov] DISCUSSION The process of myogenesis involves the commitment and differentiation of pluripotent primitive mesodermal cells into skeletal muscle and is regulated by members[doi.org]

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  • Cytotoxic Agent

    HT-1080, a fibrosarcoma cell line, and HS-42, a malignant mesodermal cell line, were the most sensitive of the cell lines to methotrexate, doxorubicin, etoposide, and paclitaxel[ncbi.nlm.nih.gov] Cell physiology [ edit ] Treating cells with the cytotoxic compound can result in a variety of cell fates.[en.wikipedia.org] The high specificity and strong cytotoxicity of cc49scFv-FasLext made it feasible to cure IP-implanted Jurkat-Ras tumors in SCID mice.[ncbi.nlm.nih.gov] Abstract The diarylsulfonylureas (DSUs) are a novel class of cytotoxic agents with high potential for activity. LY295501 is one of the most active DSUs.[ncbi.nlm.nih.gov] Moreover, Apt-Dox retained the efficacy of doxorubicin against MUC1-positive tumor cells, but lowered the toxicity to MUC1-negative cells (P[ncbi.nlm.nih.gov] They should have a full blood count on the day of the incident and 7-10 days later.[icid.salisbury.nhs.uk] This study was undertaken to isolate the active chemical constituent (Juglone) and to investigate its cytotoxic activity along with its various analogs against different human[ncbi.nlm.nih.gov]

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  • Doxorubicin

    […] of alveolar soft part sarcoma, chondrosarcoma, rhabdomyosarcoma, osteosarcoma, gastrointestinal stromal tumor, dermatofibrosarcoma, Ewing sarcoma, Kaposi sarcoma, mixed mesodermal[jamanetwork.com] The cells were exposed to 9 μM Doxo , 60 μM Etop or 20 μM Acla for the time points indicated and the fate of PAGFP-H2A was monitored by confocal laser scanning microscopy[web.archive.org] Flow cytometry analysis proved the binding efficiency of the specific aptamer to tumour cell lines.[ncbi.nlm.nih.gov] Anthracyclines induce double-strand DNA breaks at active gene promoters. Mutat Res 773:9-15. See also: Yang F, Kemp CJ, Henikoff S . 2013.[fredhutch.org] RESULTS: Treatment of JJ012 cells with 100 mM ethanol and doxorubicin resulted in reduced cell growth, invasion, and migration.[ncbi.nlm.nih.gov] Eleven months later, the patient presented with left pulmonary metastasis. She refused debulking surgery and had chemotherapy with IAP.[ncbi.nlm.nih.gov] However, one month later, the patient developed further recurrences in her pelvis and upper abdomen.[ncbi.nlm.nih.gov]

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  • Fibrodysplasia Ossificans Progressiva

    KEYWORDS: Differentiation; Disease modeling; Fibrodysplasia ossificans progressiva; Induced pluripotent stem cells; Paraxial mesoderm[ncbi.nlm.nih.gov] This mutation causes mild constitutive activation of the BMP signaling pathway and identifies ACVR1 as a key regulator of cell fate decisions and bone formation, providing[ncbi.nlm.nih.gov] Here we describe another treatment strategy for FOP using allele-specific RNA interference (ASP-RNAi), and show modified small interfering RNAs (siRNAs) conferring allele-specific[ncbi.nlm.nih.gov] […] domain as the engineered constitutively active (c.a.) variant p.Q207D.[ncbi.nlm.nih.gov] These conditions are not normally permissive in control cells.[ncbi.nlm.nih.gov] RESULTS: Fourteen lateral foot radiographs of fibrodysplasia ossificans progressiva were available for this study (ages at examination: 1-104 months).[ncbi.nlm.nih.gov] Available from: Fibrodysplasia Ossificans progressiva (FOP) is a disorder of the mesodermal tissue characterized by initial inflammation and subsequently proliferation of[ijri.org]

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  • Chronic Myeloid Leukemia

    Disorders Polycythemia Vera Essential Thrombocytosis Myelofibrosis Chronic Myelogenous Leukemia The hematopoietic stem cells are present within the bone marrow, derived from the mesoderm[lecturio.com] Carvalho Palma , Maria Gabriela Berzoti-Coelho , Sandra Mara Burin & Fabíola Attié de Castro Medical Oncology (2018) Aberrant DNA Methylation in Chronic Myeloid Leukemia: Cell Fate[nature.com] While disease-specific factors such as CML phase, mutational status, and line of treatment are key to TKI selection, other important features must be considered, such as patient-specific[ncbi.nlm.nih.gov] The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway is part of the BCR-ABL signaling network, and it is activated in CML, especially in LSCs[ncbi.nlm.nih.gov] […] mononuclear cells.[ncbi.nlm.nih.gov] One month later, he presented with progressive leukocytosis (mostly neutrophilia) and splenomegaly.[ncbi.nlm.nih.gov] The CRISPR/Cas9 system, with its mechanism of specific DNA complementary recognition by engineered guide RNA (gRNA), allows the development of novel therapeutics for CML.[ncbi.nlm.nih.gov]

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