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8,536 Possible Causes for activation, factor, growth, insulin like, of, pathway, receptor, signaling

  • Insulin-Like Growth Factor I

    Insulin-like growth factor-I (IGF-I) serum level decreases with age, and this decrease may underlie hemoglobin (Hb) decrease.[ncbi.nlm.nih.gov] Clinical trials examining insulin-like growth factor-I receptor (IGF1R)-targeting strategies have emphasized that better predictive biomarkers are required to improve patient[ncbi.nlm.nih.gov] […] in IGF1 and insulin induced signaling.[ncbi.nlm.nih.gov] No increase in growth velocity was observed over a 14-month period.[ncbi.nlm.nih.gov] At mean age 36, physical activity, fitness and IGF-I were measured.[ncbi.nlm.nih.gov] In the current study, the prognostic and predictive values of serum transforming growth factor-β1 (TGF-β1), insulin-like growth factor I (IGF-I)/IGF-I receptor (IGF-IR) and[ncbi.nlm.nih.gov] Fucoidan also partially impacted Ras/Raf signaling in the Ras/Raf/ERK pathway.[ncbi.nlm.nih.gov] This study is designed to evaluate the correlations of insulin-like growth factor I (IGF-I) and insulin-like growth factor I receptor (IGF-IR) expressions with the clinicopathological[ncbi.nlm.nih.gov]

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  • Influenza Virus

    A dual luciferase reporter assay showed that cfa-miR-143 targets insulin-like growth factor binding protein 5 (Igfbp5).[ncbi.nlm.nih.gov] The Formyl Peptide Receptor 2 (FPR2) is a novel promising target for the treatment of influenza.[ncbi.nlm.nih.gov] Wnt/β-catenin signaling is an essential pathway in cell cycle control. Dysregulation of the Wnt/β-catenin signaling pathway during viral infection has been reported.[ncbi.nlm.nih.gov] pathway to increase virus growth and enhance the expression of pro-inflammatory cytokines to increase pathogenicity.[ncbi.nlm.nih.gov] Long-term, robust growth of human DAECs was achieved using co-culture with feeder cells and supplementation with epidermal growth factor (EGF), Rho-associated protein kinase[ncbi.nlm.nih.gov] Embelin demonstrated antiviral activity, with an IC50 of 0.3 µM and an SI of 10.[ncbi.nlm.nih.gov] This study aimed to describe the clinical and epidemiologic patterns and infection factors associated with influenza, and compare case features of influenza A and B.[ncbi.nlm.nih.gov] Methods We calculated the adjusted anti-acetylcholine receptor antibody (Adj-AChR-Ab) titers (range, 0-1) in 58 MG patients between 2006 and 2012.[ncbi.nlm.nih.gov]

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  • Neuroepithelioma

    The growth hormone (GH)-insulin-like growth factor (IGF) system is also ubiquitously expressed, is also involved in energy homeostasis and shares some of the signaling molecules[ncbi.nlm.nih.gov] Northern blot analysis of SK-N-MC mRNA using cDNA probes for the beta 1- and beta 2-adrenergic receptors revealed the presence of a very strong beta 1-adrenergic receptor[ncbi.nlm.nih.gov] G protein-coupled receptors (GPCRs) are critical players in converting extracellular stimuli into intracellular signals.[ncbi.nlm.nih.gov] We have recently found that the proliferation of a neoplastic Schwann cell line is dependent on constitutive activation of the NRG-1/erbB signaling pathway and that overexpression[ncbi.nlm.nih.gov] , form which did not act as an autocrine growth modulator of A673 cells in vitro.[ncbi.nlm.nih.gov] Nevertheless, activation of all three receptor tyrosine kinases led to ERK2 activation.[ncbi.nlm.nih.gov] A series of neuroepithelioma and neuroblastoma cell lines were screened for nerve growth factor (NGF)-induced differentiation.[ncbi.nlm.nih.gov] Citing Literature Number of times cited: 153 , Pediatric Radiation Oncology , (3) Haim Werner, Shilhav Meisel-Sharon and Ilan Bruchim , Oncogenic fusion proteins adopt the insulin-like[doi.org]

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  • Ovariectomy

    like growth factor-I (IGF-I) in premenopausal women after bilateral ovariectomy.[ncbi.nlm.nih.gov] […] ovx to expand SCs; promote osteoblast proliferation and differentiation; regulate the SC production of the osteoclastogenic factors macrophage colony-stimulating factor, receptor[ncbi.nlm.nih.gov] Together our findings suggest that Cyanidin Chloride is capable of inhibiting osteoclast formation, hydroxyapatite resorption and RANKL-induced signal pathways in vitro and[ncbi.nlm.nih.gov] We also show that disruption of RANK-RANKL interactions following administration of OPG-Fc inhibits growth of these dormant tumour cells in vivo.[ncbi.nlm.nih.gov] Mesenteric artery endothelium expresses both small (SK3)- and intermediate (IK1)-conductance Ca(2 )-activated K( ) (KCa) channels whose activity modulates vascular tone via[ncbi.nlm.nih.gov] Receptor expression was not different in OVX and SHAM rats.[ncbi.nlm.nih.gov] These effects are mediated, at least in part, by cAMP and cGMP pathways. Therefore, KMUP-1 may have a role in pharmacologic therapy of osteoporosis.[ncbi.nlm.nih.gov] […] transcription factors required for OC differentiation.[ncbi.nlm.nih.gov]

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  • Ischemic Stroke

    Insulin-like growth factor I (IGF-I) has neuroprotective effects in experimental ischemic stroke (IS).[ncbi.nlm.nih.gov] The results of published studies which examined the association between variable number tandem repeat (VNTR) polymorphism of interleukin-1 receptor antagonist (IL-1RN) and[ncbi.nlm.nih.gov] Many experimental studies have shown the association of apoptosis signal-regulating kinase 1 (ASK1) with cellular pathomechanisms after cerebral ischemia.[ncbi.nlm.nih.gov] […] gene set enrichment analysis revealed that upregulated genes were enriched in a phosphatidylinositol signaling system, which is closely involved in the calcium signaling pathway[ncbi.nlm.nih.gov] Clinical evidence supports prompt IV tissue plasminogen activator administration after onset of ischemic stroke.[ncbi.nlm.nih.gov] Thrombosis is known to occur in patients with rare inherited bleeding disorders, usually in the presence of a thrombotic risk factor such as surgery and/or factor replacement[ncbi.nlm.nih.gov] A new cerebral lesion expressing somatostatin receptors was discovered in the right temporal lobe, suggestive of an ischemic stroke territory.[ncbi.nlm.nih.gov] This reactive development or "second hit" theory suggests that at a molecular level, growth factors may play a vital role in aberrant angiogenesis and maturation of an arteriovenous[ncbi.nlm.nih.gov]

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  • Echinococcus Multilocularis

    Infections are initiated through establishment of parasite larvae within the intermediate host's liver, where high concentrations of insulin are present, followed by tumour-like[ncbi.nlm.nih.gov] […] a BR-Smad, also by the human TGF-β type I receptor.[ncbi.nlm.nih.gov] This involves direct interactions of evolutionary conserved signalling systems of the receptor tyrosine--and the receptor serine/threonine-kinase pathways of the parasite[ncbi.nlm.nih.gov] In this study we present, for the first time, a three-dimensional digital reconstruction of Echinococcus multilocularis larval growth in human tissue.[ncbi.nlm.nih.gov] To explore the effect of Echinococcus multilocularis (E. multilocularis) on the activation of mitogen-activated protein kinase (MAPK) signaling pathways and on liver cell[ncbi.nlm.nih.gov] Sox transcription factors play important roles in maintenance and regulation of stem/progenitor cells.[ncbi.nlm.nih.gov] Occupational animal contact was the only risk factor significantly associated with a higher risk for being seropositive.[ncbi.nlm.nih.gov] […] in tumour growth, development and metastasis formation.[ncbi.nlm.nih.gov]

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  • Osteosarcoma

    Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) target mRNAs, including IGF2, GLI1 and CD44, were downregulated in Lnc-THOR-silenced OS cells as well.[ncbi.nlm.nih.gov] BACKGROUND G protein-coupled receptor 110 (GPR110) belongs to the subfamily of the adhesion G protein-coupled receptors (GPCRs).[ncbi.nlm.nih.gov] Melatonin inhibited of cancer stem cell by down-regulation of SOX9-mediated signaling pathway in osteosarcoma.[ncbi.nlm.nih.gov] Licoricidin suppressed activation of the Akt and nuclear factor-kappa B (NF-κB) pathways.[ncbi.nlm.nih.gov] Apcin was demonstrated to inhibit OS cell growth and induce significant apoptosis.[ncbi.nlm.nih.gov] The nuclear translocation of Gli, expression levels of Shh, Smo, Ptch1, Bcl2, active MMP2, and active MMP9 were increased in MG63R cells compared with MG63 cells.[ncbi.nlm.nih.gov] This study was aimed to reveal the changes in survival rates and prognostic factors to survival of chondroblastic osteosarcoma (COS).Patients from the Surveillance, Epidemiology[ncbi.nlm.nih.gov] PI3K/AKT activator insulinlike growth factor‑1 (IGF‑1) significantly activated the PI3K/Akt/mTOR signaling and reversed the suppressive effects of GPNMB silencing.[ncbi.nlm.nih.gov]

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  • Hantaan Virus

    Four apoptotic genes, the insulin-like growth factor binding protein 1, NFkB inhibitor alpha, caspase-3 and NFkB1 were up-regulated in both infected and uninfected Cor-treated[ncbi.nlm.nih.gov] The cellular entry of Hantaan virus (HTN) occurs through interactions with beta(3) integrins as cellular receptors.[ncbi.nlm.nih.gov] These results suggest that the HTNV circumvents host antiviral signaling and apoptotic response mediated by the TNFR pathway through host interactions with the N protein.[ncbi.nlm.nih.gov] The growth arrest-specific 6 (Gas6) protein and TAM (Tyro3, Axl and Mer) receptors have been recently shown to play prominent roles in immune regulation, and high plasma levels[ncbi.nlm.nih.gov] FPI was not toxic to mammalian cells at concentrations that exhibited antiviral activity.[ncbi.nlm.nih.gov] Multiple viruses have developed evasion strategies to circumvent the host cell inflammatory process, with one of the most prevalent being the disruption of nuclear factor[ncbi.nlm.nih.gov] CD163, a hemoglobin scavenger receptor for haptoglobin-hemoglobin complexes, is expressed by monocytes/macrophages and is often shed as soluble CD163 (sCD163) in response[ncbi.nlm.nih.gov] The virulence of the pathogenic hantaviruses is determined by their ability to alter key signaling pathways of early interferon (IFN) induction within cells.[ncbi.nlm.nih.gov]

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  • Uremia

    […] processing and transport, protein transport, chaperone functions, the unfolded protein response and genes involved in tumor genesis were prominently lower in uremia, while insulin-like[ncbi.nlm.nih.gov] Because IS is an agonist of the aryl hydrocarbon receptor (AHR), we first examined the relationship between IS levels and AHR-inducing activity in sera of patients with ESRD[ncbi.nlm.nih.gov] Immune signal-induced CYP27B1 expression, conversely, is impaired in uremic conditions.[ncbi.nlm.nih.gov] […] hyperplasia contributes to high serum parathyroid hormone (PTH) and also to an impaired suppression of secondary hyperparathyroidism by calcium, vitamin D and fibroblast growth[ncbi.nlm.nih.gov] Increased factor VIII/von Willebrand factor antigen and von Willebrand factor activity in renal failure. Am J Med 66:226. 1979. 7. Watson AJS, Keogh JAB.[kjim.org] Serum amyloid A (SAA) is an acute phase protein and a binding partner for the multiligand receptor for advanced glycation end products (RAGE).[ncbi.nlm.nih.gov] First, we investigated the role of core fucosylation and key TGF-β1 pathway receptors in calcified arteries in vivo.[ncbi.nlm.nih.gov] […] bleeding tendency associated with platelet dysfunction, and previous studies have shown abnormalities of platelet glycoprotein (GP) Ib or GPIIb/IIIa and a tendency for platelet activation[ncbi.nlm.nih.gov]

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  • Low Protein Diet

    Expression of the insulin receptor (Insr) and insulin-like growth factor I receptor (Igf1r) in retroperitoneal fat was significantly elevated in Emb-LPD females (P 0.05),[ncbi.nlm.nih.gov] In heart tissue of LP offspring, beta1-adrenergic receptor expression was reduced (P 0.03). beta1-Adrenergic receptor kinase and both stimulatory and inhibitory G protein[ncbi.nlm.nih.gov] […] of AAR pathway-related genes.[ncbi.nlm.nih.gov] Fibroblast growth factor 21 (FGF21) is considered a promising therapeutic candidate for the treatment of obesity.[ncbi.nlm.nih.gov] These data provide evidence that a low-protein diet is able to activate autophagy and is safe and tolerable in patients with COL6 myopathies, pointing at autophagy activation[ncbi.nlm.nih.gov] […] therapeutic effects of low protein diet (LPD) for chronic renal failure (CRF) in compliant patients with the diet, and to clarify the relationships to the sociopsychological factors[ncbi.nlm.nih.gov] Very Low-Protein Diet (VLPD) Reduces Metabolic Acidosis in Subjects with Chronic Kidney Disease: The “Nutritional Light Signal” of the Renal Acid Load.[mdpi.com] Angiotensin-converting enzyme inhibitors and/or angiotensin receptor blockers have been considered effective at slowing the progression of kidney function deterioration.[ncbi.nlm.nih.gov]

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