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9,667 Possible Causes for activation, immunity, leukocyte, mediated, of

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  • Acute Inflammation

    […] roles of eosinophils and eosinophil-derived lipid mediators in controlling acute inflammation and resolution.[ncbi.nlm.nih.gov] Provided the antigen is cleared and the immune system of the host is fully functional, the acute inflammatory response will resolve.[ncbi.nlm.nih.gov] Previous studies on EGC pathophysiology have specifically focused on mucosal glia activation and its contribution to mucosal inflammatory processes observed in the gut of[ncbi.nlm.nih.gov] Here, we report that miR-466l was temporally regulated in murine exudate-infiltrating leukocytes.[ncbi.nlm.nih.gov] […] provide an overview of the process of resolution with a focus on the enzymatic biosynthesis and receptor-dependent actions of resolvins and related proresolving mediators in immunity[ncbi.nlm.nih.gov]

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  • Influenza

    Abstract Immune-mediated necrotizing myopathy is a very rare inflammatory disease affecting skeletal muscles.[ncbi.nlm.nih.gov] Immune thrombocytopenia (ITP) is an isolated autoimmune condition, often preceded by a viral infection.[ncbi.nlm.nih.gov] Seasonal influenza activity in the Southern Hemisphere was low overall, with influenza A(H1N1)pdm09 predominating in many regions.[ncbi.nlm.nih.gov] Histopathologic examination and enumeration of polymorphonuclear leukocytes in the nasal mucosa during experimental rhinovirus colds.[dx.doi.org] Prevention and control of influenza: recommendations of the Advisory Committee on Immunization Practices [ACIP]. MMWR 2004;53[No. RR-6]:1-40).[ncbi.nlm.nih.gov]

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  • Infectious Mononucleosis

    CASE CHARACTERISTICS: A 17-year-old boy with Epstein-Barr virus related infectious mononucleosis and cold antibody-mediated autoimmune hemolytic anemia with incidentally noted[ncbi.nlm.nih.gov] KEYWORDS: acute infection; anti-viral immunity; cytokines; dendritic cells; herpesvirus; immune dysregulation; immune regulation; virus[ncbi.nlm.nih.gov] The mitogen responses were decreased and natural killer (NK) cell activity was low.[dx.doi.org] ABSTRACT Cultures were initiated with peripheral leukocytes from individuals: (i) in the acute stage of infectious mononucleosis (IM); (ii) with past histories of IM; and[jvi.asm.org] Corticosteroids may have a role in hastening resolution of some complications, especially upper airway obstruction and possibly immune-mediated anemia and thrombocytopenia[dx.doi.org]

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  • Inflammation

    Serhan Annual Review of Immunology The Role of Cell-Mediated Immune Responses in Resistance to Malaria, with Special Reference to Oxidant Stress Anthony C.[doi.org] Abstract The immune reconstitution inflammatory syndrome is an exaggerated abnormal immune response, typically seen in HIV-positive patients following restoration of a normal[ncbi.nlm.nih.gov] Finally, the AMP-activated protein kinase (AMPK) and its downstream S6 kinase (S6K) were detected in CSE-stimulated BECs.[ncbi.nlm.nih.gov] […] to adherent leukocytes.[ncbi.nlm.nih.gov] These results suggest that miR‑214 mediates vascular inflammation and apoptosis via PTEN expression.[ncbi.nlm.nih.gov]

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  • Immune Complex–Mediated Small Vessel Vasculitis

    91 Immune Complex–Mediated Small Vessel Vasculitis Key Points Vasculitis mediated by immune complexes (ICs) includes a heterogeneous group of disorders linked by inefficient[musculoskeletalkey.com] Patients may have active Wegener’s granulomatosis in the absence of ANCA; the absolute height of the antibody titers does not correlate well with disease activity; and patients[what-when-how.com] The leukocytes that are drawn in by the chemotactic factors are activated by engagement of their C3b and Fc receptors by the immune complexes.[humpath.com] […] immune complexes ( antigen - antibody complexes) that have not been adequately cleared by innate immune cells , giving rise to an inflammatory response and attraction of leukocytes[en.wikipedia.org] In the skin, palpable purpura, the most common cutaneous finding in IC-mediated vasculitis, results from extravasation of erythrocytes through damaged vessel walls ( Plate[ime.acponline.org]

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  • Leukocyte Adhesion Deficiency Syndrome

    Our results suggest looking for a possible kindlin-3 involvement in membrane dynamical event independent of integrin-mediated adhesion.[ncbi.nlm.nih.gov] Abstract Important insights into the molecular basis of leukocyte emigration have come from studies of the leukocyte adhesion deficiency (LAD) syndrome, a rare heritable disorder[ncbi.nlm.nih.gov] In view of the important role of selectins in lymphocyte migration and homing, we have explored the in vivo immune responsiveness and lymphocyte recruitment to the skin, in[academic.oup.com] Both constitutive and chemokine-triggered activation of Rap1 were abolished in LAD lymphocytes despite normal chemokine signaling.[ncbi.nlm.nih.gov] […] of leukocytes to the endothelium.[orpha.net]

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  • Skin Infection

    This review summarizes recent discoveries regarding the role of cytokines-mediated responses in host defense against S. aureus skin infection, and discusses their implications[ncbi.nlm.nih.gov] However, recent evidence has led to the hypothesis of immune cross-reactivity between emm types.[ncbi.nlm.nih.gov] The weak activity against bacteria was found in the aqueous extract of some plant ingredients.[ncbi.nlm.nih.gov] Abstract Leukocyte adhesion deficiency (LAD) I is a well-described genetic disorder in which leukocytes are unable to migrate to sites of inflammation due to mutations in[ncbi.nlm.nih.gov] In contrast, recent clinical and experimental findings clearly highlight the critical roles of innate and T cell-mediated immunity in defense against these infections.[ncbi.nlm.nih.gov]

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  • Urinary Tract Infection

    TLR4-mediated expulsion of bacteria from infected bladder epithelial cells . Proc. Natl Acad. Sci. USA 106 , 14966–14971 (2009). 29.[doi.org] This resistance to infection is mainly ascribed to the versatility of the innate immune defences in the urinary tract, as the adaptive immune responses are limited particularly[ncbi.nlm.nih.gov] The present investigation was designed to study the effect of an active compound isolated from Justicia wynaadensis against multi drug resistant organisms (MDRO's) associated[ncbi.nlm.nih.gov] However, leukocyte response of recipients to lipopolysaccharide was impaired irrespective of donor and recipient sex to the same extend.[ncbi.nlm.nih.gov] Aims: To determine whether deoxyribonucleic acid (DNA) polymorphisms at the plasminogen activator inhibitor -1 (PAI-1) gene were associated with evolution to RS following[ncbi.nlm.nih.gov]

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  • Herpes Simplex Virus 1 Infection

    Here, we describe the regulation of STING via RIG-I-mediated innate immune sensing.[ncbi.nlm.nih.gov] Chemokines regulate leukocyte trafficking to inflamed tissues and play a crucial role in orchestrating the immune response to HSV-1 infection.[ncbi.nlm.nih.gov] Mice that received immune serum survived without developing latent HSV-1 infection.[ncbi.nlm.nih.gov] Additionally, caspase 7 was found to be activated during HSV-1-dependent apoptosis.[ncbi.nlm.nih.gov] Although the double-stranded RNA-dependent protein kinase (PKR) is activated during HSV infection, the gamma(1)34.5 protein inhibits the activity of PKR by mediating dephosphorylation[ncbi.nlm.nih.gov]

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  • Upper Respiratory Infection

    The mechanism of viral-mediated UVFP has not been established. Future studies to explore this pathophysiology are needed.[ncbi.nlm.nih.gov] Brain Behav Immun. 2008 Jul;22(5):769-80. doi: 10.1016/j.bbi.2008.01.004. Epub 2008 Feb 21.[ncbi.nlm.nih.gov] […] in recreational activity.[doi.org] There is an increase in both leukocyte infiltration and nasal secretions, including large amounts of protein and immunoglobulin, suggesting that cytokines and immune mechanisms[ncbi.nlm.nih.gov] CONCLUSION: T2R38 appears to be an important mediator of sinonasal epithelial defense, but further study is needed to more clearly determine how TAS2R38 genotype affects patient[ncbi.nlm.nih.gov]

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