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9,307 Possible Causes for activation, kinase, of, of, pathway, protein, regulation, signaling, stress activated

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  • Kallmann Syndrome Type 3

    […] receptor 2, an integral membrane protein and G protein-coupled receptor whose activation triggers the mobilization of calcium, phosphoinositide turnover, and p44/p42 MAP kinase[] About 5-10% of these cases are attributed to impaired signaling via the PROK2/PROKR2 pathway, which is affected in KS3 and Kallmann syndrome type 4.[] GnRH, LH, FSH, and the sex hormones are all part of the hypothalamic-pituitary-gonadal axis, which regulates the development of primary and secondary sexual characteristics[] This gene is located on the short arm of chromosome 20 and encodes for prokineticin receptor 2, an integral membrane protein and G protein-coupled receptor whose activation[] About 5-10% of these cases are attributed to impaired signaling via the PROK2/PROKR2 pathway, which is affected in KS3 and Kallmann syndrome type 4.[] KS3 interferes with the maturation and activity of the gonads, and the development of secondary sexual characteristics is usually disturbed.[] PROK2/PROKR2 signaling plays a key role in the development of the olfactory bulb and the migration of GnRH and olfactory neurons along the olfactory nerve pathway: Both types[] […] regard to the underlying molecular mechanisms, PROKR2 mutations identified in KS3 patients could be shown to affect cell surface-targeting of the receptor, coupling to G proteins[] PROK2/PROKR2 signaling plays a key role in the development of the olfactory bulb and the migration of GnRH and olfactory neurons along the olfactory nerve pathway: Both types[]

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  • T-cell Acute Lymphoblastic Leukemia

    KEYWORDS: ETP-ALL; PIM kinase; T-ALL; ponatinib; tyrosine kinase inhibitor[] The identification of specific genomic alterations has contributed to identify strong oncogenic drivers and signaling pathways regulating leukemia growth.[] Our results suggest that miR-146b-5p is a functionally relevant microRNA gene in the context of T-ALL, whose negative regulation by TAL1 and possibly other oncogenes contributes[] * Neoplasm Proteins/biosynthesis Neoplasm Proteins/genetics Nuclear Proteins/antagonists & inhibitors Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy* Protein[] We stress the importance of careful initial neurologic evaluation of children with malignancy.[] We also identified evidence of NOTCH3 activation in 12 of 24 patient-derived orthotopic xenograft models, 2 of which exhibit activation of NOTCH3 without activation of NOTCH1[] In conclusion, our data demonstrate that miR-125b regulates differentiation and reprogramming of T cell glucose metabolism via targeting A20.[] MLN4924 also induced nucleolar disruption, suggesting nucleolar stress signaling might contribute to the anticancer effects of MLN4924 in T-ALL cells.[] MeSH terms, Substances MeSH terms Cell Line, Tumor Gene Expression Regulation, Leukemic Humans Immunoglobulin J Recombination Signal Sequence-Binding Protein/biosynthesis[]

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  • Ataxia Telangiectasia

    Compound 27g was also significantly more selective against other kinases than 4.[] […] for ATM signalling by IR.[] Atm therefore plays a critical role in T cell proliferation by regulating responses to ROS generated following T cell activation.[] Here we identified that Cpn10/HSPE, a 10-kDa heat shock protein, is a novel interacting partner of NPAT.[] In this study, white matter motor pathway integrity was investigated in ataxia telangiectasia patients using diffusion MRI and probabilistic tractography.[] I show for the first time that ATM can be activated by oxidative stress directly in the form of exposure to H₂O₂.[] Our results from cell line and animal models showed that Pak1 is activated in response to UV-B radiation, and this activated Pak1 translocates from the cytoplasm to the nucleus[] In the present study, we demonstrated that TNF-α promoted lung cancer cell migration by up-regulation of matrix metalloproteinase-13 (MMP-13).[] To enhance the anticancer effects of EGFR-TKIs, we examined the cross-talk of the EGFR pathways with ataxia telangiectasia-mutated (ATM) signaling pathways.[]

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  • Inflammation

    […] factor 88, and glycogen synthase kinase-3.[] KEYWORDS: Akt phosphorylation; Inflammation; Macrophage foam cell; TLR4 signaling; mTORC2[] Abstract The regulation of protein synthesis was determined in livers from control, sterile inflammatory, and septic animals.[] In conclusion, this review identified inflammatory pathway as the key signaling for determining the efficacy of P. notoginseng on chronic diseases.[] Of note, liquiritin treatment in mice and cells exposed to UVB showed reduced inflammatory response, oxidative stress and apoptosis through inhibiting the activation of TLR4[] Finally, the AMP-activated protein kinase (AMPK) and its downstream S6 kinase (S6K) were detected in CSE-stimulated BECs.[] Recent advancements in our understanding of inflammatory triggers, imprinting of the innate immune responses, and the role of T cell memory in regulating inflammation are[] Lipopolysaccharide regulates proinflammatory cytokine expression in mouse myoblasts and skeletal muscle. Am J Physiol Regul Integr Comp Physiol 283 : R698–R709, 2002 .[] These results suggested that 'psoriasis 1' suppressed the inflammatory response and the activation of the NF‑κB and STAT signaling pathways.[]

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  • Cardiac Hypertrophy

    Myosin light chain kinase (MLCK), a specific kinase for the phosphorylation of myosin light chain 2 (MLC2), plays an important role in regulating cardiac muscle contraction[] KEYWORDS: Exercise; Heart; IGF1-PI3K-Akt signaling[] […] the level, subcellular and temporal activities of the extracellular signal-regulated kinases (ERKs), c-Jun N-terminal kinases (JNKs) and p38 MAPKs.[] […] endothelial-derived protein to modulate heart remodeling in response to pressure overload.[] Zinc supplement ameliorates ORCH through activation of metallothionein to repress oxidative stress-activated BCL10 expression and p38 MAPK activation. 2017 The Authors.[] These, again, were reduced by addition of the phytoestrogen with activation of ERs.[] Mechanistically, our study suggests that TRIM8 may elicit cardiodetrimental effects by promoting the activation of transforming growth factor β-activated kinase 1 (TAK1)-p38[] , which results in the induction of genes involved in hypertrophy and survival pathways.[] […] to hypertrophic stress, and blockage of TAK1 activation abolished the pathological effects of USP4 deficiency in vivo.[]

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  • LIG4 Syndrome

    […] important vertebrate Gtf that -O-GlcNAcylates a multitude of nuclear and cytoplasmic protein, including transcription elements, cytoskeletal protein, metabolic enzymes, kinases[] ATR-Seckel syndrome is caused by mutations in ataxia telangiectasia and Rad3 related protein (ATR), a component of a DNA damage signalling pathway.[] Despite significant progress demonstrating how XLF and XRCC4 regulate Ligase IV function, little is known about how Ligase IV regulates NHEJ.[] Tandem BRCT domains of LigIV mediate a unique mode of protein-protein interaction.[] End joining pathways in CSR in Lig4D patients A number of alternative NHEJ pathways have been proposed in yeast and vertebrates ( 18 ).[] Given the expected severe effect of Dnl4 catalytic mutation on ligase activity and c-NHEJ, it was striking that these same mutants supported residual NHEJ activity in the[] Analysis of additional mutational changes in LIG4 syndrome (R580X, R814X and G469E) have led to the identification of a nuclear localization signal in DNA ligase IV and sites[] […] of the signal ends to alternative NHEJ.[] Epub 2004 Aug 27. 2004 22LIG4 Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase. Wang YG, Nnakwe C, Lane WS, Modesti M, Frank KM.[]

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  • Herpes Simplex Virus 1

    IMPORTANCE TANK binding kinase 1 plays a key role in antiviral immunity.[] ICP0 and ICP34.5 are among the proteins encoded by herpes simplex virus 1 (HSV-1) that modulate type I IFN signaling.[] During viral infection, accumulation of viral proteins can cause stress in the endoplasmic reticulum (ER) and trigger the unfolded protein response (UPR) to restore ER homeostasis[] […] lines did not activate interferon-stimulated gene (ISG) transcription following treatment with the noncanonical cyclic dinucleotide 2',3'-cGAMP, suggesting that the STING pathway[] Although Us3 did not detectably prevent energy stress-induced AMPK activation, it enforced mTORC1 activation despite the presence of activated AMPK.[] Overall, our findings implicate activated HPSE as a driver of viral pathogenesis and call for further attention to this host protein in infection and other inflammatory disorders[] However, little is known about the interaction between DNA viruses such as HSV-1 and the MAVS-Pex mediated signaling.[] The other evaluated peptides did not show significant antiviral activity.[] Furthermore, we demonstrated that UL34 was required for efficient targeting of these regulators to the NM.[]

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  • CDK4-linked Melanoma

    The CDK4 gene encodes for cyclin-dependent kinase 4, the catalytic subunit of a serine-threonine kinase involved the regulation of the cell cycle.[] […] within DNA Bioengineering experts have discovered how to predict the efficiency with which transcription factors (TFs) locate the sites they need to bind to in order to regulate[] […] levels, compared with that seen in a panel of normal tissues, were observed in 76% of the tumours, accompanied in 71% of the cases by high expression of the CCND1 cyclin activator[] The latter enhances CDK4-mediated signaling as depicted above.[] […] of certain cells rather than just recording their spontaneous activity.[] As the p16 protein is involved in a cell cycle regulatory pathway consisting of at least pRb, cdk4 and cyclin D1, the tumours were also screened for amplifications of the[] The CDK4 gene encodes for cyclin-dependent kinase 4, an enzyme involved in cell cycle regulation.[] […] hemochromatosis behind many cancers and joint diseases Enhancing HD-MEA Systems with CMOS One reason selective stimulation is valuable is that it allows you to control the activity[] […] accordance with the postulated negative feedback loop between p16 and pRb, one melanoma cell line showed overexpression of CDKN2 mRNA together with very low levels of the Rb protein[]

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  • Herpes Simplex Virus 1 Infection

    Here we show that HSV infection also induces phosphorylation of an endoplasmic reticulum (ER) resident kinase PERK, a hallmark of ER stress response.[] STING induction significantly contributed to sustainment of the immune signaling cascade following 5'pppRNA treatment.[] Sections from the cultured TG fragments were stained with antisera against non-structural proteins such as the immediate early (IE) protein ICP27 and the early (E) proteins[] Moreover, more than one pathway may be involved in the death of particular cell type.[] Additionally, caspase 7 was found to be activated during HSV-1-dependent apoptosis.[] Center for Biochemistry, University of Cologne, Cologne, Germany. 2 Department of Dermatology, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress[] […] the murine model, we found that TCP decreased the severity of wild-type-virus-induced encephalitis and corneal blindness, infection with the acyclovir-resistant (thymidine kinase-negative[] In this review we will focus on the pathways that induce chemokine expression during HSV-1 infection and the implications of chemokine signaling on control of viral replication[] These genes regulated by circRNAs were enriched to NOD-like receptor/JAK-STAT signaling pathway, and pathways of apoptosis, cell cycle progression, and cell death, all of[]

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  • Glucocorticoid

    ; MKP-1, mitogen-activated protein kinase phosphatase; ARE, AU-rich element; JNK, c-Jun N-terminal kinase; GILZ, glucocorticoid-inducible leucine zipper; Dok, downstream of[] The GR can also mediate rapid nongenomic signaling events initiated in the cytoplasm.[] Regulation of Release/Mode of Action Drawback Hyposecreation- Hyposecreation of glucocorticoids cause Addission diseases and they are the followings.[] […] arise from disturbances in these pathways.[] These results suggest that activation of the hypothalamic–pituitary–adrenal cortex (HPA) axis mediates the impairing effects of footshock stress on retention for spatial memory[] Renal NPR-A activation induces potent diuresis and natriuresis, whereas hypothalamic NPR-A activation inhibits dehydration-induced water intake [4] , [5] .[] Collectively, glucocorticoids could improve renal responsiveness to ANP by up-regulating NPR-A expression in the IMCD and induce a potent diuretic action in rats with decompensated[] […] generating survival signals or suppressing signals involved in controlling T cell survival ( Fig. 3 ).[] "Introduction Classification Pharmacological Action Regulation of Release and Drawback of Glucocorticoids Hormone".[]

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