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9,307 Possible Causes for activation, kinase, of, of, pathway, protein, regulation, signaling, stress activated

Did you mean: activation, kinase, of, of, pathway, protein, regulation, signaling, stress, activated

  • Kallmann Syndrome Type 3

    […] receptor 2, an integral membrane protein and G protein-coupled receptor whose activation triggers the mobilization of calcium, phosphoinositide turnover, and p44/p42 MAP kinase[symptoma.com] About 5-10% of these cases are attributed to impaired signaling via the PROK2/PROKR2 pathway, which is affected in KS3 and Kallmann syndrome type 4.[symptoma.com] GnRH, LH, FSH, and the sex hormones are all part of the hypothalamic-pituitary-gonadal axis, which regulates the development of primary and secondary sexual characteristics[symptoma.com] This gene is located on the short arm of chromosome 20 and encodes for prokineticin receptor 2, an integral membrane protein and G protein-coupled receptor whose activation[symptoma.com] About 5-10% of these cases are attributed to impaired signaling via the PROK2/PROKR2 pathway, which is affected in KS3 and Kallmann syndrome type 4.[symptoma.com] KS3 interferes with the maturation and activity of the gonads, and the development of secondary sexual characteristics is usually disturbed.[symptoma.com] PROK2/PROKR2 signaling plays a key role in the development of the olfactory bulb and the migration of GnRH and olfactory neurons along the olfactory nerve pathway: Both types[symptoma.com] […] regard to the underlying molecular mechanisms, PROKR2 mutations identified in KS3 patients could be shown to affect cell surface-targeting of the receptor, coupling to G proteins[symptoma.com] PROK2/PROKR2 signaling plays a key role in the development of the olfactory bulb and the migration of GnRH and olfactory neurons along the olfactory nerve pathway: Both types[symptoma.com]

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  • T-cell Acute Lymphoblastic Leukemia

    KEYWORDS: ETP-ALL; PIM kinase; T-ALL; ponatinib; tyrosine kinase inhibitor[ncbi.nlm.nih.gov] The identification of specific genomic alterations has contributed to identify strong oncogenic drivers and signaling pathways regulating leukemia growth.[ncbi.nlm.nih.gov] Our results suggest that miR-146b-5p is a functionally relevant microRNA gene in the context of T-ALL, whose negative regulation by TAL1 and possibly other oncogenes contributes[ncbi.nlm.nih.gov] * Neoplasm Proteins/biosynthesis Neoplasm Proteins/genetics Nuclear Proteins/antagonists & inhibitors Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy* Protein[ncbi.nlm.nih.gov] We stress the importance of careful initial neurologic evaluation of children with malignancy.[ncbi.nlm.nih.gov] We also identified evidence of NOTCH3 activation in 12 of 24 patient-derived orthotopic xenograft models, 2 of which exhibit activation of NOTCH3 without activation of NOTCH1[ncbi.nlm.nih.gov] In conclusion, our data demonstrate that miR-125b regulates differentiation and reprogramming of T cell glucose metabolism via targeting A20.[ncbi.nlm.nih.gov] MLN4924 also induced nucleolar disruption, suggesting nucleolar stress signaling might contribute to the anticancer effects of MLN4924 in T-ALL cells.[ncbi.nlm.nih.gov] MeSH terms, Substances MeSH terms Cell Line, Tumor Gene Expression Regulation, Leukemic Humans Immunoglobulin J Recombination Signal Sequence-Binding Protein/biosynthesis[ncbi.nlm.nih.gov]

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  • Ataxia Telangiectasia

    Compound 27g was also significantly more selective against other kinases than 4.[ncbi.nlm.nih.gov] […] for ATM signalling by IR.[doi.org] Atm therefore plays a critical role in T cell proliferation by regulating responses to ROS generated following T cell activation.[ncbi.nlm.nih.gov] Here we identified that Cpn10/HSPE, a 10-kDa heat shock protein, is a novel interacting partner of NPAT.[ncbi.nlm.nih.gov] In this study, white matter motor pathway integrity was investigated in ataxia telangiectasia patients using diffusion MRI and probabilistic tractography.[ncbi.nlm.nih.gov] I show for the first time that ATM can be activated by oxidative stress directly in the form of exposure to H₂O₂.[hdl.handle.net] Our results from cell line and animal models showed that Pak1 is activated in response to UV-B radiation, and this activated Pak1 translocates from the cytoplasm to the nucleus[ncbi.nlm.nih.gov] In the present study, we demonstrated that TNF-α promoted lung cancer cell migration by up-regulation of matrix metalloproteinase-13 (MMP-13).[ncbi.nlm.nih.gov] To enhance the anticancer effects of EGFR-TKIs, we examined the cross-talk of the EGFR pathways with ataxia telangiectasia-mutated (ATM) signaling pathways.[ncbi.nlm.nih.gov]

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  • Inflammation

    […] factor 88, and glycogen synthase kinase-3.[ncbi.nlm.nih.gov] KEYWORDS: Akt phosphorylation; Inflammation; Macrophage foam cell; TLR4 signaling; mTORC2[ncbi.nlm.nih.gov] Abstract The regulation of protein synthesis was determined in livers from control, sterile inflammatory, and septic animals.[doi.org] In conclusion, this review identified inflammatory pathway as the key signaling for determining the efficacy of P. notoginseng on chronic diseases.[ncbi.nlm.nih.gov] Of note, liquiritin treatment in mice and cells exposed to UVB showed reduced inflammatory response, oxidative stress and apoptosis through inhibiting the activation of TLR4[ncbi.nlm.nih.gov] Finally, the AMP-activated protein kinase (AMPK) and its downstream S6 kinase (S6K) were detected in CSE-stimulated BECs.[ncbi.nlm.nih.gov] Recent advancements in our understanding of inflammatory triggers, imprinting of the innate immune responses, and the role of T cell memory in regulating inflammation are[ncbi.nlm.nih.gov] Lipopolysaccharide regulates proinflammatory cytokine expression in mouse myoblasts and skeletal muscle. Am J Physiol Regul Integr Comp Physiol 283 : R698–R709, 2002 .[doi.org] These results suggested that 'psoriasis 1' suppressed the inflammatory response and the activation of the NF‑κB and STAT signaling pathways.[ncbi.nlm.nih.gov]

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  • Cardiac Hypertrophy

    Myosin light chain kinase (MLCK), a specific kinase for the phosphorylation of myosin light chain 2 (MLC2), plays an important role in regulating cardiac muscle contraction[ncbi.nlm.nih.gov] KEYWORDS: Exercise; Heart; IGF1-PI3K-Akt signaling[ncbi.nlm.nih.gov] […] the level, subcellular and temporal activities of the extracellular signal-regulated kinases (ERKs), c-Jun N-terminal kinases (JNKs) and p38 MAPKs.[ncbi.nlm.nih.gov] […] endothelial-derived protein to modulate heart remodeling in response to pressure overload.[ncbi.nlm.nih.gov] Zinc supplement ameliorates ORCH through activation of metallothionein to repress oxidative stress-activated BCL10 expression and p38 MAPK activation. 2017 The Authors.[ncbi.nlm.nih.gov] These, again, were reduced by addition of the phytoestrogen with activation of ERs.[ncbi.nlm.nih.gov] Mechanistically, our study suggests that TRIM8 may elicit cardiodetrimental effects by promoting the activation of transforming growth factor β-activated kinase 1 (TAK1)-p38[ncbi.nlm.nih.gov] , which results in the induction of genes involved in hypertrophy and survival pathways.[qiagen.com] […] to hypertrophic stress, and blockage of TAK1 activation abolished the pathological effects of USP4 deficiency in vivo.[ncbi.nlm.nih.gov]

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  • LIG4 Syndrome

    […] important vertebrate Gtf that -O-GlcNAcylates a multitude of nuclear and cytoplasmic protein, including transcription elements, cytoskeletal protein, metabolic enzymes, kinases[perlierusa.com] ATR-Seckel syndrome is caused by mutations in ataxia telangiectasia and Rad3 related protein (ATR), a component of a DNA damage signalling pathway.[ncbi.nlm.nih.gov] Despite significant progress demonstrating how XLF and XRCC4 regulate Ligase IV function, little is known about how Ligase IV regulates NHEJ.[docksci.com] Tandem BRCT domains of LigIV mediate a unique mode of protein-protein interaction.[mcb.asm.org] End joining pathways in CSR in Lig4D patients A number of alternative NHEJ pathways have been proposed in yeast and vertebrates ( 18 ).[jem.rupress.org] Given the expected severe effect of Dnl4 catalytic mutation on ligase activity and c-NHEJ, it was striking that these same mutants supported residual NHEJ activity in the[journals.plos.org] Analysis of additional mutational changes in LIG4 syndrome (R580X, R814X and G469E) have led to the identification of a nuclear localization signal in DNA ligase IV and sites[ncbi.nlm.nih.gov] […] of the signal ends to alternative NHEJ.[kundoc.com] Epub 2004 Aug 27. 2004 22LIG4 Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase. Wang YG, Nnakwe C, Lane WS, Modesti M, Frank KM.[genatlas.medecine.univ-paris5.fr]

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  • Herpes Simplex Virus 1

    IMPORTANCE TANK binding kinase 1 plays a key role in antiviral immunity.[ncbi.nlm.nih.gov] ICP0 and ICP34.5 are among the proteins encoded by herpes simplex virus 1 (HSV-1) that modulate type I IFN signaling.[ncbi.nlm.nih.gov] During viral infection, accumulation of viral proteins can cause stress in the endoplasmic reticulum (ER) and trigger the unfolded protein response (UPR) to restore ER homeostasis[ncbi.nlm.nih.gov] […] lines did not activate interferon-stimulated gene (ISG) transcription following treatment with the noncanonical cyclic dinucleotide 2',3'-cGAMP, suggesting that the STING pathway[ncbi.nlm.nih.gov] Although Us3 did not detectably prevent energy stress-induced AMPK activation, it enforced mTORC1 activation despite the presence of activated AMPK.[ncbi.nlm.nih.gov] Overall, our findings implicate activated HPSE as a driver of viral pathogenesis and call for further attention to this host protein in infection and other inflammatory disorders[ncbi.nlm.nih.gov] However, little is known about the interaction between DNA viruses such as HSV-1 and the MAVS-Pex mediated signaling.[ncbi.nlm.nih.gov] The other evaluated peptides did not show significant antiviral activity.[ncbi.nlm.nih.gov] Furthermore, we demonstrated that UL34 was required for efficient targeting of these regulators to the NM.[ncbi.nlm.nih.gov]

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  • CDK4-linked Melanoma

    The CDK4 gene encodes for cyclin-dependent kinase 4, the catalytic subunit of a serine-threonine kinase involved the regulation of the cell cycle.[symptoma.com] […] within DNA Bioengineering experts have discovered how to predict the efficiency with which transcription factors (TFs) locate the sites they need to bind to in order to regulate[news-medical.net] […] levels, compared with that seen in a panel of normal tissues, were observed in 76% of the tumours, accompanied in 71% of the cases by high expression of the CCND1 cyclin activator[ncbi.nlm.nih.gov] The latter enhances CDK4-mediated signaling as depicted above.[symptoma.com] […] of certain cells rather than just recording their spontaneous activity.[news-medical.net] As the p16 protein is involved in a cell cycle regulatory pathway consisting of at least pRb, cdk4 and cyclin D1, the tumours were also screened for amplifications of the[ncbi.nlm.nih.gov] The CDK4 gene encodes for cyclin-dependent kinase 4, an enzyme involved in cell cycle regulation.[symptoma.com] […] hemochromatosis behind many cancers and joint diseases Enhancing HD-MEA Systems with CMOS One reason selective stimulation is valuable is that it allows you to control the activity[news-medical.net] […] accordance with the postulated negative feedback loop between p16 and pRb, one melanoma cell line showed overexpression of CDKN2 mRNA together with very low levels of the Rb protein[ncbi.nlm.nih.gov]

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  • Herpes Simplex Virus 1 Infection

    Here we show that HSV infection also induces phosphorylation of an endoplasmic reticulum (ER) resident kinase PERK, a hallmark of ER stress response.[ncbi.nlm.nih.gov] STING induction significantly contributed to sustainment of the immune signaling cascade following 5'pppRNA treatment.[ncbi.nlm.nih.gov] Sections from the cultured TG fragments were stained with antisera against non-structural proteins such as the immediate early (IE) protein ICP27 and the early (E) proteins[ncbi.nlm.nih.gov] Moreover, more than one pathway may be involved in the death of particular cell type.[ncbi.nlm.nih.gov] Additionally, caspase 7 was found to be activated during HSV-1-dependent apoptosis.[ncbi.nlm.nih.gov] Center for Biochemistry, University of Cologne, Cologne, Germany. 2 Department of Dermatology, University of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress[ncbi.nlm.nih.gov] […] the murine model, we found that TCP decreased the severity of wild-type-virus-induced encephalitis and corneal blindness, infection with the acyclovir-resistant (thymidine kinase-negative[ncbi.nlm.nih.gov] In this review we will focus on the pathways that induce chemokine expression during HSV-1 infection and the implications of chemokine signaling on control of viral replication[ncbi.nlm.nih.gov] These genes regulated by circRNAs were enriched to NOD-like receptor/JAK-STAT signaling pathway, and pathways of apoptosis, cell cycle progression, and cell death, all of[ncbi.nlm.nih.gov]

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  • Glucocorticoid

    ; MKP-1, mitogen-activated protein kinase phosphatase; ARE, AU-rich element; JNK, c-Jun N-terminal kinase; GILZ, glucocorticoid-inducible leucine zipper; Dok, downstream of[doi.org] The GR can also mediate rapid nongenomic signaling events initiated in the cytoplasm.[ncbi.nlm.nih.gov] Regulation of Release/Mode of Action Drawback Hyposecreation- Hyposecreation of glucocorticoids cause Addission diseases and they are the followings.[websparrow.org] […] arise from disturbances in these pathways.[doi.org] These results suggest that activation of the hypothalamic–pituitary–adrenal cortex (HPA) axis mediates the impairing effects of footshock stress on retention for spatial memory[doi.org] Renal NPR-A activation induces potent diuresis and natriuresis, whereas hypothalamic NPR-A activation inhibits dehydration-induced water intake [4] , [5] .[doi.org] Collectively, glucocorticoids could improve renal responsiveness to ANP by up-regulating NPR-A expression in the IMCD and induce a potent diuretic action in rats with decompensated[doi.org] […] generating survival signals or suppressing signals involved in controlling T cell survival ( Fig. 3 ).[doi.org] "Introduction Classification Pharmacological Action Regulation of Release and Drawback of Glucocorticoids Hormone".[en.wikipedia.org]

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