Create issue ticket

494 Possible Causes for activation, microtubule, of, polymerization

Did you mean: amotivation, microtubule, of, polymerization

  • Colchicine

    KEYWORDS: Colchicine; Drug resistance; Microtubule dynamics; Microtubule stability; Tubulin isotypes[ncbi.nlm.nih.gov] Natural products such as colchicine and vinblastine inhibit microtubule assembly by preventing tubulin polymerization.[ncbi.nlm.nih.gov] Abstract In this paper we provide an overview of the status of various colchicine derivatives in preclinical development with special focus on their anti-cancer activity.[ncbi.nlm.nih.gov] The cytotoxicity of the compounds, their ability to inhibit the expression of oncogenes related to telomerase activation and to the VEGF/VEGFR-2 autocrine process, such as[ncbi.nlm.nih.gov]

    Missing: of
  • Influenza

    Dynein-Directed Transport on Microtubules in Stage II.[doi.org] Porter & Drew Weissman Nature Reviews Drug Discovery (2018) Formulation, characterization and evaluation of mRNA-loaded dissolvable polymeric microneedles (RNApatch) Kai Jun[doi.org] Seasonal influenza activity in the Southern Hemisphere was low overall, with influenza A(H1N1)pdm09 predominating in many regions.[ncbi.nlm.nih.gov] Nationally, ILI activity began increasing in November, reaching an extended period of high activity during January-February, and remaining elevated through March.[ncbi.nlm.nih.gov]

    Missing: of
  • Vinca Alkaloid

    Microtubule-associated protein (MAP) MAP4 binds to and stabilizes microtubules, and increased expression is associated with decreased sensitivity to microtubule-depolymerizing[ncbi.nlm.nih.gov] S 12363 was also active in vivo against a P388 leukemia subline resistant to vincristine.[ncbi.nlm.nih.gov] These agents are known to inhibit microtubule polymerization.[ncbi.nlm.nih.gov] Studies of drug interactions with the drug target, tubulin or microtubules, have helped us to understand the cytotoxic and toxic effects.[ncbi.nlm.nih.gov]

    Missing: of
  • Dementia

    Tau is a microtubule-associated protein, abundant in neurons, which promotes and stabilizes tubulin assembly into microtubules.[doi.org] Strittmatter , Rescue of Transgenic Alzheimer’s Pathophysiology by Polymeric Cellular Prion Protein Antagonists , Cell Reports , 10.1016/j.celrep.2018.12.021 , 26 , 1 , (145[doi.org] Background: Nursing home (NH) residents with dementia experience a reduced quality of life (QoL), in part, due to a dependence in performing activities of daily living (ADL[ncbi.nlm.nih.gov] Hyperphosphorylated tau protein alters the polymerization and stability of microtubules compromising their function ( 31 Iqbal K , Grue-Iqbal I .[doi.org]

    Missing: of
  • Vinblastine

    […] and inhibited the reassembly of cold-depolymerized microtubules in MCF-7 cells.[ncbi.nlm.nih.gov] The other type is also made up of tubulin subunits, but these do not seem to have polymerized into microtubules.[ncbi.nlm.nih.gov] We compared control and resistant L. amazonensis ecto-enzymatic activities.[ncbi.nlm.nih.gov] Studies with goat brain tubulin indicated that indirubin bound to tubulin at a single site with a dissociation constant of 26   3 μM and inhibited the in vitro polymerization[ncbi.nlm.nih.gov]

    Missing: of
  • Paclitaxel

    Microtubule dynamics assays revealed that DPT destabilized microtubule assembly in a different mode.[ncbi.nlm.nih.gov] Encapsulation of PTX in polymeric nanoparticles is used to overcome these problems but these micelles still need improvements in stability, pharmacokinetics, therapeutic efficacy[ncbi.nlm.nih.gov] Moreover, KER-NPs-PTX activity was compared to free PTX and to PTX loaded in albumin nanoparticles (HSA-NPs-PTX).[ncbi.nlm.nih.gov] Materials and methods: We prepared smart polymeric nanoparticles (NPs) with pH-responsive and poly(ethylene glycol) (PEG)-detachable properties to systemically co-deliver[ncbi.nlm.nih.gov]

    Missing: of
  • Cytotoxic Agent

    It would also be an interesting probe for the structure-function studies of tubulin-microtubule system.[ncbi.nlm.nih.gov] Further studies showed that BPR0Y007 inhibits tubulin polymerization in vivo and in vitro, and induces apoptosis in a concentration-dependent manner.[ncbi.nlm.nih.gov] Abstract The diarylsulfonylureas (DSUs) are a novel class of cytotoxic agents with high potential for activity. LY295501 is one of the most active DSUs.[ncbi.nlm.nih.gov] We found that azatoxin inhibited tubulin polymerization in vitro and was a mitotic inhibitor at 1 microM and above in the human colon cancer cell line KM20L2.[ncbi.nlm.nih.gov]

    Missing: of
  • Vincristine

    Datasheet References Product name Vincristine sulfate salt, Microtubule inhibitor Description Microtubule inhibitor Biological description Anticancer agent; microtubule depolymerizer[abcam.com] Based on nanotechnology such as liposomes, polymeric nanoparticles, and lipid nanoparticles, recent research efforts have been aimed to target drugs to the brain.[ncbi.nlm.nih.gov] FINDINGS: The patient was a CYP3A5 nonexpressor and presented with reduced CYP3A4/5 functional activity, a likely reason for the occurrence of the adverse event, as genotyping[ncbi.nlm.nih.gov] The synergistic anti-proliferative effect of ROSI and VCR was associated with inhibition on tubulin polymerization, cell cycle arrest in G2/M phase and cell apoptosis induction[ncbi.nlm.nih.gov]

    Missing: of
  • Docetaxel

    Targets Microtubules (Cell-free assay) Solubility Solubility (25 C) * In vitro DMSO 162 mg/mL (200.52 mM) Water Ethanol 162 mg/mL (200.52 mM) In vivo 30% PEG400/0.5% Tween80[adooq.com] OBJECTIVE: The goal of the present work was to make novel co-polymeric micellar carriers for the delivery of docetaxel (DTX).[ncbi.nlm.nih.gov] […] leading to greater antitumor activity against antigen-positive tumors.[ncbi.nlm.nih.gov] In most cases, the apparent lack of microtubules was due to microtubules leaving the plane of the optical section shown; however, in other cases, the distribution of microtubules[molbiolcell.org]

    Missing: of
  • Griseofulvin

    At or near half-maximal proliferation inhibitory concentration, griseofulvin dampened the dynamicity of microtubules in MCF-7 cells without significantly disrupting the microtubule[ncbi.nlm.nih.gov] […] to affect MT polymerization and dynamic instability in vitro.[ncbi.nlm.nih.gov] Abstract Griseofulvin, an antifungal drug, has been shown in recent years to have anti-proliferative activities.[ncbi.nlm.nih.gov] […] to affect MT polymerization and dynamic instability in vitro .[ncbi.nlm.nih.gov]

    Missing: of