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7,259 Possible Causes for activator, delta, mouse, peroxisome, proliferator, protein,, receptor

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  • Troglitazone

    Abstract The aims of this study were to assess the utility of the PXB mouse model of a chimeric human/mouse liver in studying human-specific effects of an important human[ncbi.nlm.nih.gov] Abstract The role of the peroxisome proliferator-activated receptor-γ (PPARγ) in cell differentiation, cell cycle arrest and apoptosis has attracted increasing attention.[ncbi.nlm.nih.gov] Abstract Peroxisome proliferator-activated receptors (PPAR) belong to the nuclear hormone receptor superfamily of ligand-dependent transcription factors.[ncbi.nlm.nih.gov] We report here that troglitazone augments AMP-activated protein kinase-alpha (AMPKalpha) phosphorylation, reduces p70S6 kinase phosphorylation and stimulates autophagy that[ncbi.nlm.nih.gov] HCT116-XIAP( / ) cells and HCT116-XIAP(-/-) cells were treated with troglitazone or 15-deoxy-Delta(12,14)-prostaglandin J2 (15-PGJ2) with or without prior exposure to PPARgamma[ncbi.nlm.nih.gov] Abstract Agonist ligands for the nuclear receptor peroxisome proliferator-activated receptor-gamma have been shown to induce terminal differentiation of normal preadipocytes[ncbi.nlm.nih.gov] […] in T-lymphocyte activation.[ncbi.nlm.nih.gov]

  • Telmisartan

    […] administrated telmisartan on brain inflammation features including microglial activation, astrogliosis, neuronal loss and hippocampus-dependent cognition in five-familial AD mouse[ncbi.nlm.nih.gov] In humans, mutations in the peroxisome proliferator-activated receptor-gamma (PPARgamma) have been reported to cause the full-blown metabolic syndrome, and drugs that activate[ncbi.nlm.nih.gov] In conclusion, telmisartan inhibits human HCC cell proliferation by inducing cell cycle arrest.[ncbi.nlm.nih.gov] BACKGROUND: G-protein β-polypeptide 3 (GNB3) is a β subunit isoform of G-protein that plays important role in signal transduction of membrane G-protein coupled receptors ([ncbi.nlm.nih.gov] Co-incubation with siRNA of PPAR-delta inhibited the telmisartan effect of PPAR-delta up-regulation.[ncbi.nlm.nih.gov] Peroxisome proliferator-activated receptor δ (PPARδ), a versatile regulator of metabolic homeostasis, may be a potential therapeutic target.[ncbi.nlm.nih.gov] Our results indicate that telmisartan can be considered as a novel AMPK activator, suppressing microglia activation by promoting M2 polarization.[ncbi.nlm.nih.gov]

  • Bezafibrate

    The mitochondrial DNA (mtDNA) mutator mouse is a mouse model of aging that harbors a proofreading-deficient mtDNA polymerase γ.[ncbi.nlm.nih.gov] Receptors PPAR alpha RNA, Messenger Receptors, IgG Bezafibrate[ncbi.nlm.nih.gov] Author information 1 Department of Nutrition and Food, Harbin Medical University, Heilongjiang, China. [email protected] Abstract Fibrates, the ligands of peroxisome proliferator-activated[ncbi.nlm.nih.gov] Abstract Mitochondrial trifunctional protein (MTP) deficiency caused by HADHA or HADHB gene mutations exhibits substantial molecular, biochemical, and clinical heterogeneity[ncbi.nlm.nih.gov] Together, these data implicate PPAR beta/delta in fuel combustion and suggest that pan-PPAR agonists that include a component of PPAR beta/delta activation might offset some[ncbi.nlm.nih.gov] The goal of this study was to evaluate the effect of the peroxisome proliferator-activated receptor ligand bezafibrate on the progression of impaired fasting glucose phase[ncbi.nlm.nih.gov] Nuclear peroxisome proliferator-activated receptors (PPAR), which play a central role in lipid and glucose metabolism, had been hypothesized as being involved in colon cancerogenesis[ncbi.nlm.nih.gov]

  • T-cell Acute Lymphoblastic Leukemia

    Yet, retroviral insertional mutagenesis screens identify RUNX genes as collaborating oncogenes in MYC-driven leukemia mouse models.[ncbi.nlm.nih.gov] Interleukin-7 and interleukin-7 receptor are essential for normal T-cell development and homeostasis, whereas excessive interleukin-7/interleukin-7 receptor-mediated signaling[ncbi.nlm.nih.gov] These data indicate that Lhx2 is capable of blocking proliferation of T-ALL-derived cells by both LMO2-dependent and -independent means.[ncbi.nlm.nih.gov] * Neoplasm Proteins/biosynthesis Neoplasm Proteins/genetics Nuclear Proteins/antagonists & inhibitors Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy* Protein[ncbi.nlm.nih.gov] […] genetics Receptors, Antigen, T-Cell, gamma-delta/immunology* Receptors, Antigen, T-Cell, gamma-delta/metabolism Survival Analysis T-Lymphocytes/immunology* T-Lymphocytes[ncbi.nlm.nih.gov] […] protein level i Names & Taxonomy i Organism-specific databases Subcellular location i Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome[uniprot.org] We also identified evidence of NOTCH3 activation in 12 of 24 patient-derived orthotopic xenograft models, 2 of which exhibit activation of NOTCH3 without activation of NOTCH1[ncbi.nlm.nih.gov]

  • Pioglitazone

    […] of PPARγ on the anti-inflammatory response, in this study we evaluated the antidepressant-like effects of the PPARγ agonist pioglitazone in CMS-induced depression using a mouse[doi.org] Abstract Pioglitazone (PGZ), a peroxisome proliferator-activated receptor γ agonist, which is known as a type 2 diabetes drug, inhibits cell proliferation in various cancer[ncbi.nlm.nih.gov] FOXA2 effectively reversed the effect of miR‑141 overexpression on β cell proliferation.[ncbi.nlm.nih.gov] […] known proteins.[ncbi.nlm.nih.gov] Gene Name PPARD Uniprot ID Q03181 Uniprot Name Peroxisome proliferator-activated receptor delta Molecular Weight 49902.99 Da References Inoue I, Itoh F, Aoyagi S, Tazawa S[drugbank.ca] Thus, pioglitazone can increase catalase activity by changing the BLC structure. Copyright 2017 John Wiley & Sons, Ltd.[ncbi.nlm.nih.gov] Abstract The peroxisome proliferator-activated receptor gamma (PPAR γ) agonists have been reported to have antiproliferative and tumor-suppressive effects.[ncbi.nlm.nih.gov]

  • Rosiglitazone

    […] expressions of intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 in human brain microvascular endothelial cells (hCMEC/D3) and C57BL/6J mouse[ncbi.nlm.nih.gov] Abstract Anti-inflammatory effects of peroxisome proliferator-activated receptor gamma (PPRAγ) ligands are thought to be largely due to PPARγ-mediated transrepression.[ncbi.nlm.nih.gov] METHODS: Cell proliferation was evaluated by [3H]-thymidine assay.[ncbi.nlm.nih.gov] Indoxyl sulphate is a protein-bound uraemic toxin that has deleterious effects on the cardiovascular system.[ncbi.nlm.nih.gov] Diaglinex (Farmindustria) / Gaudil (Craveri) / Gliximina (Denver) / Naidi (Hisun) / Rogelin (Torrent) / Roglit (Gedeon Richter) / Romerol (Drug International) / Rosit (Delta[drugbank.ca] In contrast, the expression of Na( )/H( ) exchanger-3 (NHE3) and NKCC2 was unchanged in either mouse strain.[ncbi.nlm.nih.gov] Peroxisome proliferator-activated receptor gamma (PPARγ) is a member of the large nuclear hormone receptor transcription factor superfamily, and has been recently implicated[ncbi.nlm.nih.gov]

  • LIG4 Syndrome

    […] send to {{ username }} {{geneWatchAttr}} Analyze Gene Strain QTL List Functional Annotation unavailable Annotation Distribution unavailable Genomic Variants unavailble for Mouse[rgd.mcw.edu] NHEJ is also used to repair the DNA double-strand break intermediates that occur in the production of T and B lymphocyte receptors.[en.wikipedia.org] In Vitro Lymphocyte Proliferation.[pnas.org] Tandem BRCT domains of LigIV mediate a unique mode of protein-protein interaction.[mcb.asm.org] Journal of Clinical Investigation 102 , 312 - 321 57 Ehl , S. et al. ( 2005 ) A variant of SCID with specific immune responses and predominance of gamma delta T cells .[cambridge.org] […] protein level i Names & Taxonomy i Organism-specific databases Subcellular location i Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome[uniprot.org] Given the expected severe effect of Dnl4 catalytic mutation on ligase activity and c-NHEJ, it was striking that these same mutants supported residual NHEJ activity in the[journals.plos.org]

  • Familial Partial Lipodystrophy

    Abstract We investigated the role of LMNA in adipose tissue by developing a novel mouse model of lipodystrophy.[ncbi.nlm.nih.gov] The gene encoding retinoic acid receptor B (RARB) showed a higher methylation in all six patients with FPLD2 when compared with the progeria patients with other LMNA mutations[ncbi.nlm.nih.gov] We studied peroxisome proliferator-activated receptor-gamma (PPARgamma) gene as a candidate gene in seven FPL patients who did not appear to have Dunnigan variety.[ncbi.nlm.nih.gov] 1 Instituto Estadual de Diabetes e Endocrinologia do Rio de Janeiro, Rio de Janeiro, Brasil. [email protected] Abstract OBJECTIVE: To determine Retinol Binding Protein[ncbi.nlm.nih.gov] Free testosterone levels were 15.3 pg/ml (N 12.5); delta 4 androstenedione was 3.7 ng/ml ( N 3.1), LH increased from 9.3 to 110 mUI/ml and FSH from 3 to 8 mUI/ml after LH-RH[em-consulte.com] […] partial lipodystrophy (Dunnigan) type 3 (FPLD3, Mendelian Inheritance in Man [MIM] 604367) results from heterozygous mutations in PPARG encoding peroxisomal proliferator-activated[ncbi.nlm.nih.gov] We also examined adipogenic conversion of mouse embryonic fibroblasts lacking A-type lamins.[ncbi.nlm.nih.gov]

  • Inflammation

    This figure shows Flow Cytometry Analysis of mouse bone marrow stained with anti-mouse CD44-PE (yellow). Isotype control labeling is shown in gray. Learn More[emdmillipore.com] Abstract The formyl peptide receptors (FPRs) are G protein coupled receptors that recognize a broad range of structurally distinct pathogen and danger-associated molecular[ncbi.nlm.nih.gov] The effect of rLRRFIP-1 on cellular proliferation, inflammation, and collagen deposition was also investigated.[ncbi.nlm.nih.gov] The rate of protein synthesis in vivo was measured by the incorporation of [3H]phenylalanine into liver proteins in a chronic (5 day) intra-abdominal abscess model.[doi.org] In this study, we integrated 5 Cytokine-Chips from genome-wide DNA methylation datasets of the 3 kind of AIDs, delta-beta value was calculated for intergroup difference, and[ncbi.nlm.nih.gov] This study aims to investigate the role of peroxisome proliferator-activated receptor (PPAR) g in cigarette smoking-induced inflammation.[ncbi.nlm.nih.gov] {gamma}{delta} T cell-induced hyaluronan production by epithelial cells regulates inflammation . J. Exp. Med. 201 , 1269–1279 (2005). 7. Adamson, I.Y. & Bowden, D.H.[doi.org]

  • Glucocorticoid

    Results Human and mouse Th17 cells and mouse Th2 cells were resistant to glucocorticoid‐induced apoptosis.[doi.org] However, clinical utility can be compromised by the development of side effects, many of which are attributed to the ability of the glucocorticoid receptor (GR) to induce[doi.org] In the thymus, this was due to increased apoptosis in the organ, whereas proliferation of thymocyte populations was unaffected.[ncbi.nlm.nih.gov] To diagnose CIRCI, the clinician may use a delta serum cortisol 34 ).[ncbi.nlm.nih.gov] […] protein level i Names & Taxonomy i Organism-specific databases Subcellular location i Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome[uniprot.org] Renal NPR-A activation induces potent diuresis and natriuresis, whereas hypothalamic NPR-A activation inhibits dehydration-induced water intake [4] , [5] .[doi.org] […] hormone increases the gluconeogenesis (formation of glucose) process. 2- Fat Metabolism: Glucocorticoid hormone helps to increase lypogenesis (formation of lipids) process, proliferation[websparrow.org]