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11,194 Possible Causes for activity, agmatine, deiminase

  • Arginine

    This peptide exhibited higher anticancer activity and penetrability against solid tumor cells than lycosin-I.[] We report the first pharmacokinetic and clinical response data from a patient with unresectable hepatocellular cancer treated with a new drug, ADI PEG20,000 mw (arginine deiminase-polyethylene[] Abstract The l-arginine/agmatine transporter AdiC is a prokaryotic member of the SLC7 family, which enables pathogenic enterobacteria to survive the extremely acidic gastric[]

  • Argininosuccinic Aciduria

    Synonyms arginine succinate synthetase activity , argininosuccinate synthetase activity , argininosuccinic acid synthetase activity , arginosuccinate synthetase activity ,[] Phase I/II study of pegylated arginine deiminase (ADI-PEG 20) in patients with advanced melanoma. Invest New Drugs . 2013;31(2):425-434.[] […] the synthesis of urea and ornithine as part of the urea cycle but it is also the substrate for the synthesis of nitric oxide, polyamines, proline, glutamate, creatine, and agmatine[]

  • Streptococcus Mutans

    We developed a screening system for GTF-inhibitory activities, and used it to profile 44 types of herbal tea extracts.[] In addition to this mechanism, some oral streptococci use the arginine deiminase pathway to survive a decrease in environmental pH ( 8 ).[] However, most of the remaining drinks significantly inhibited biofilm growth and metabolic activity.[]

  • Mycoplasma Penetrans

    Hemolytic activity diffused from single colonies, eventually causing complete lysis.[] In this work we present the crystal structures of the three enzymes composing the gene cluster of the arginine deiminase pathway from M. penetrans: arginine deiminase (ADI[] "Structural Characterization of the Enzymes Composing the Arginine Deiminase Pathway in Mycoplasma penetrans" .[]

    Missing: agmatine
  • Porphyromonas Gingivalis

    Antimicrobial activity was also observed against P. gingivalis grown on blood agar plates.[] In particular, the peptidylarginine deiminase enzyme of P. gingivalis (PPAD) has been implicated in the citrullination of certain host proteins and the subsequent appearance[] Our study aimed to determine the effect of Pg and its LPS on the expression of peptidyl arginine deiminase isotypes (PADs) in human primary chondrocytes (HC).[]

    Missing: agmatine
  • Lactococcus Lactis

    They also showed inhibitory activities on IL-6-induced STAT3 activation, and showed the different in activity according to the presence of a phenylalanine residue, hydroxyl[] Remarkably, all the putrescine-producing strains used the agmatine deiminase pathway.[] Among these genes arcD1 encodes the arginine/ornithine antiporter, which is involved in arginine deiminase (ADI) pathway 23 .[]

  • Polygala Tenuifolia

    Pharmacological studies revealed PTPa and PTPb significantly inhibited the growth of A549 cells in vitro and exhibited significantly higher antitumor activity against solid[] DaveJ on 15th Mar 2018 Does help especially when combined with agmatine sulfate.[] In order to test the anti-cancer activity of PTP, we investigated its effect against the growth of human ovarian cancer cells SKOV3 in vitro and in ovarian cancer rats.[]

    Missing: deiminase
  • Streptococcus Pyogenes

    AD from GAS type M22 suppressed the proliferative activity of endothelial cells in a dose-dependent mode.[] Arginine deiminase (arcA) hydrolyzing L-arginine into L-citrulline and ammonia is the first enzyme of this catabolic pathway.[] activator of ProT.[]

    Missing: agmatine
  • Giardia Lamblia

    Herein, we report Larrea tridentata, known as creosote bush, as a novel source for secondary metabolites that display antiparasitic activity against all three pathogens.[] In particular, we examine the multiple roles played by the enzyme arginine deiminase during colonization of the gut, also involving the parasite's mechanism of antigenic variation[] Additionally, the synergistic action of albendazole in combination with each of the most active 2-aryl-3-hydroxymethyl imidazo[1,2-a]pyridines and pyrimidines was also assessed[]

    Missing: agmatine
  • Candida Albicans

    In this study, we examined their antifungal activity against C. albicans in vitro.[] The success of this pathogen in the host colonization and infection results from the presence of several virulence factors, including extracellular peptidylarginine deiminase[] Herein, we report a structure-activity relationship study on this peptide with the aim of designing a more potent peptide for further development.[]

    Missing: agmatine