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17 Possible Causes for activity, bilirubin, monoglucuronide, transglucuronidase

  • Crigler-Najjar Syndrome

    […] prolongation of the terminal half-life of radioactively labelled bilirubin and a fall in bilirubin clearance in every instance. 6.[ncbi.nlm.nih.gov] We demonstrate that five mutants have residual activity that, depending on the substrate, varies from not detectable to 94% of wild-type UGT1A1 activity.[ncbi.nlm.nih.gov] Bilirubin UDPGT activity, assayed by a microassay with HPLC analysis, was not detectable in type I livers, and low levels (9-26% of controls) of monoglucuronide conjugates[ncbi.nlm.nih.gov] […] pre-surgical level (4.4 mg/dl), we analyzed the duodenal bile for bilirubin fractions; those showed a marked reduction in bilirubin diglucuronide and a marked increase in bilirubin monoglucuronide[ncbi.nlm.nih.gov]

    Missing: transglucuronidase
  • Gilbert's Disease

    Bilirubin IXalpha is recognised as a potent antioxidant.[ncbi.nlm.nih.gov] There is around 30% decrease in the activity of hepatic bilirubin UGT in patients with GS.[symptoma.com] This reaction leads to the production of water-soluble bilirubin monoglucuronide and bilirubin diglucuronide.[emedicine.medscape.com] Serum bilirubin and genes controlling bilirubin concentrations as biomarkers for cardiovascular disease.[jama.ama-assn.org]

    Missing: transglucuronidase
  • Rotor Syndrome

    Bilirubin, a breakdown product of heme, is normally glucuronidated and excreted by the liver into bile.[ncbi.nlm.nih.gov] De novo insertions of retrotransposition-active L1s can result in genetic diseases.[ncbi.nlm.nih.gov] Type II CN is an autosomal dominant disorder in which patients have some UGT1A1 activity, but it’s decreased (the enzyme is only capable of forming monoglucuronidated bilirubin[pathologystudent.com] In the liver, uridine diphosphate (UDP)-glucuronyl transferase converts bilirubin to a mixture of monoglucuronides and diglucuronides, referred to as conjugated bilirubin,[emedicine.medscape.com]

    Missing: transglucuronidase
  • Crigler-Najjar Syndrome Type 2

    Some hormones and antibiotics may inhibit the enzyme's activity.[symptoma.com] This reaction leads to the production of water-soluble bilirubin monoglucuronide and bilirubin diglucuronide.[emedicine.medscape.com] The results of other liver function tests, glucose-6-phosphate dehydrogenase activity and hematology tests were normal, and immunologic tests for hepatitis A, B and C were[ncbi.nlm.nih.gov] The Crigler-Najjar syndrome (type I) is a rare disorder in which there is absent activity of the bilirubin conjugating enzyme, UDP-glucuronyl transferase.[einstein.pure.elsevier.com]

    Missing: transglucuronidase
  • Dubin-Johnson Syndrome

    These results indicate that defects in both conjugated and unconjugated bilirubin metabolism exist in DJS.[ncbi.nlm.nih.gov] […] mediate ATP-dependent transport of leukotriene C(4) (LTC(4)) into vesicles from plasma membrane and endoplasmic reticulum preparations while normal MRP2 was functionally active[ncbi.nlm.nih.gov] Uridine diphosphate (UDP)-glucuronyl transferase is the compound which converts bilirubin to a mixture of monoglucuronides and diglucuronides (conjugate bilirubin) in the[symptoma.com] No significant difference was found in enzyme activity between the two groups in either blood lysate or liver homogenate.[ncbi.nlm.nih.gov]

    Missing: transglucuronidase
  • Physiological Neonatal Jaundice

    Rubaltelli FF (1993) Bilirubin metabolism in the newborn. Biol Neonate 63: 133–138 PubMed CrossRef Google Scholar 4.[link.springer.com] In the newborn liver, activity of glucuronyl transferase is only at 0.1-1% of adult levels, so conjugation of bilirubin is already reduced.[slideshare.net] Takes place in two stages: 1) monoglucuronide bilirubin, 2) bilirubin diglicuronide the esterification of propionic central second chain, or 2 molecules can merge monoglicuronide[spazioinwind.libero.it] A successful surgery, seeing the defib monitor showing signs of cardiac activity after a successful CPR, and the cry of a baby immediately after birth.[firstclassmed.com]

    Missing: transglucuronidase
  • Transient Familial Neonatal Hyperbilirubinemia

    […] of bilirubin to bilirubin glucuronides, (iii) excretion of conjugated bilirubin into bile, and (iv) reuptake of conjugated bilirubin by hepatocytes.[nature.com] UGT activity toward bilirubin is modulated by various hormones.[emedicine.medscape.com] […] serum bilirubin must be considered.[acutecaretesting.org] […] heterozygously (UGT1A6*1/*2) it is associated with low enzyme activity.[david.ncifcrf.gov]

    Missing: transglucuronidase
  • Recurrent Jaundice of Pregnancy 

    Levels of bilirubin rise in the maternal circulation during the second and third trimesters of pregnancy, causing itching, bile staining of urine, and a lighter stool color[medical-dictionary.thefreedictionary.com] The risk of stillbirth in an ICP pregnancy is believed to be the same as that of a pregnancy with no complications (1%) with active management (which usually means treatment[liverfoundation.org] Bilirubin is excreted in the bile primarily as bilirubin diglucuronide (80%), bilirubin monoglucuronide (20%), and unconjugated bilirubin ( Figure 37–1.[mhmedical.com] […] liver biopsies 10 Liver blood flow ... 10 Hemoglobin and serum iron ... 11 Total leucocyte and differential count. 11 Prothrombin time 11 Urinary bile components 11 Serum bilirubin[books.google.de]

    Missing: transglucuronidase
  • Benign Recurrent Intrahepatic Cholestasis

    In primary biliary cirrhosis (2) the bile acid and bilirubin concentrations changed in parallel until the onset of liver failure when serum bilirubin, but not bile acids,[ncbi.nlm.nih.gov] Characteristically serum GGT activity is low and normal liver structure is preserved.[ncbi.nlm.nih.gov] CN-II • CN-II is only infrequently associated with kernicterus • Bile is deeply colored • Bilirubin glucuronides are present (Characteristic increase in the proportion of monoglucuronides[slideshare.net] Increased serum 7 alpha-hydroxycholesterol is probably indicative of an accelerated bile acid synthesis rate due to increased activity of cholesterol 7 alpha-hydroxylase,[ncbi.nlm.nih.gov]

    Missing: transglucuronidase
  • Curcumin

    Both transferrin receptor 1 and activated IRP, indicators of iron depletion, increased in response to curcumin.[ncbi.nlm.nih.gov] Curcumin may exert choleretic effects by increasing biliary excretion of bile salts, cholesterol, and bilirubin, as well as increasing bile solubility [ 2 ] .[drugbank.ca] For curcumin this leads to curcumin monoglucuronide ( 7 ), curcumin monosulfate ( 8 ), and curcumin sulfate-glucuronide ( 9 ).[doi.org] The reaction products of HO-1 induction, biliverdin, and its subsequent metabolite, bilirubin, have antioxidant properties [ 45 ].[doi.org]

    Missing: transglucuronidase