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387 Possible Causes for activity, decarboxylase, orotic

  • Flumazenil

    In the temporal area, [(11)C]FMZ binding showed a strong inverse correlation with HPA axis activity.[] Abnormally high levels of orotic acid were found in serum and urine, confirming the diagnosis of ornithine transcarbamylase deficiency.[] 50924, Cologne, Germany. [email protected] Abstract Stiff Person Syndrome (SPS) is a rare autoimmune disorder associated with antibodies against glutamic acid decarboxylase[]

  • Argininosuccinic Aciduria

    Hence, while ASL is the only enzyme in the body able to generate arginine, at least four enzymes use arginine as substrate: arginine decarboxylase, arginase, nitric oxide[] Synonyms arginine succinate synthetase activity , argininosuccinate synthetase activity , argininosuccinic acid synthetase activity , arginosuccinate synthetase activity ,[] In urine we found elevated concentrations of uracil in Cases 1 and 2, and orotic acid in Case 2.[]

  • Hereditary Orotic Aciduria without Megaloblastic Anemia

    […] of the protein, which corresponds to orotate phosphoribosyltransferase (OPRT), may remain functional, while the activity of the C-terminal subunit orotidine-5’-phosphate decarboxylase[] Orotic aciduria is a disease yielding an excessive excretion of orotic acid in urine because of the inability to convert orotic acid to.[] The ratio of OPRT activity to ODC activity does not differ from the wild-type enzyme, and percentages of residual enzyme activity are equal for both subunits.[]

  • Mycoplasma Penetrans

    Hemolytic activity diffused from single colonies, eventually causing complete lysis.[] Orotate-related metabolism is related to an ATP synthesis system called the arginine dihydrolase pathway (1).[] This study is the first one reporting phospholipase A1 activity in Mollicutes.[]

  • Hereditary Orotic Aciduria

    We have compared certain physicochemical properties of orotidine-5′-phosphate decarboxylase from normal and mutant fibroblasts grown under identical conditions.[] In the cancer cells, the OPRT activity is paralleled with the UPRT activity.[] Conclusion Patients with orotic aciduria with and without megaloblastic anemia cannot be distinguished by ratio of orotic acid to orotidine.[]

  • Nonketotic Hyperglycinemia

    The activity of the T-protein was normal.[] CSF amino acids, lactate level, electrolyte panel, urine analysis, an arterial blood gas, fresh urine for sulfites (assessing for molybdenum cofactor deficiency), urine orotic[] KEYWORDS: GLDC gene; glycine decarboxylase; glycine metabolism; nonketotic hyperglycinemia[]

  • Pyruvate Carboxylase Deficiency

    METHODS AND RESULTS: Enzyme analysis of cultured skin fibroblasts revealed 2-5% of normal pyruvate carboxylase activity.[] 1 ---*Orotic Acid Orotidine Ornithine carbamoyltransferase deficiency X 7 ---*Orotic acid X X X ---Uracil X X Argininemia ---*Orotic acid X X DISORDERS OF PYRIMIDINE METABOLISM[] Liver biopsies revealed a decrease in pyruvate carboxylase activity and normal pyruvate decarboxylase activity.[]

  • Mitochondrial Myopathy

    Long sinus pauses were documented, and an atrial pacemaker with an active-fixation lead was implanted.[] Plasma orotate can also be absorbed by the liver ( 29 ), excreted by the kidney ( 29 ), and taken up by erythrocytes ( 29 ).[] .: Clinical studies of a patient with pyruvate decarboxylase deficiency. Arch. Neurol. 25 , 449–460 (1971) Google Scholar Bradley, W. G., Jenkinson, M., Park, D.[]

  • Attention Deficit Hyperactivity Disorder

    […] event-related potentials for the incongruent condition closely resembled those in the control, suggesting that dexamphetamine successfully normalises electroencephalographic activity[] Repeated evaluations revealed hyperammonemia and orotic aciduria, and she was diagnosed as having an OTC deficiency.[] DOPA decarboxylase activity in attention deficit hyperactivity disorder in adults. A [fluorine-18] fluorodopa positron emission tomographic study.[]

  • Purine-Nucleoside Phosphorylase Deficiency

    […] in purine or pyrimidine metabolism, namely, guanine deaminase, hypoxanthine guanine phosphoribosyltransferase, orotate phosphoribosyltransferase, orotidine monophosphate decarboxylase[] Kinase activity towards deoxyguanosine was significantly higher in T-cells, whereas NP activity was similar in both B- and T-cells.[] The possible cause of the slight increase in urinary orotic acid in our patient has been discussed.[]