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11,185 Possible Causes for activity, desaturase, thalian diol

  • Scutellaria Baicalensis

    The pure compounds were evaluated for anti-influenza activities against A/WSN/33 (H1N1) virus in MDCK cells, cytotoxic activities against HepG2, SW480 and MCF7 human cancer[ncbi.nlm.nih.gov] […] program with downregulation of gene and protein expression of SREBP-1c (both precursor and mature fraction) and acetyl-CoA carboxylase, fatty acid synthase and stearoyl-CoA desaturase[ncbi.nlm.nih.gov] Wogonin and S. baicaleisis down-regulated the telomerase activity.[ncbi.nlm.nih.gov]

    Missing: thalian diol
  • Mastitis

    These indicate that IL-6/STAT3 signaling is activated in PCM and may play an important role in the pathogenesis of PCM.[ncbi.nlm.nih.gov] Stearoyl-CoA desaturase 1 (SCD1) desaturates long chain fatty acids and is therefore a key enzyme in fat catabolism.[ncbi.nlm.nih.gov] The increases were inhibited by hemin and the inhibition of hemin on ROS production and NLRP3 inflammasome activation were blocked by ZnPP.[ncbi.nlm.nih.gov]

    Missing: thalian diol
  • Perilla

    Olfactory stimulation with perilla essential oil reduced prefrontal cortex activity, thereby inducing physiologic relaxation.[ncbi.nlm.nih.gov] ; FATA/B, acyl-ACP thioesterase A/B; FAD6, oleate desaturase (chloroplast-type); FAD7/8, linoleate desaturase (chloroplast-type).[bmcgenomics.biomedcentral.com] Thirteen aroma-active compounds were detected by GC-O.[ncbi.nlm.nih.gov]

    Missing: thalian diol
  • High Fat Diet

    Peroxisome proliferator-activated receptor α (PPARα) plays a protective role against non-alcoholic fatty liver disease (NAFLD).[ncbi.nlm.nih.gov] This antiobesity effect was attributed to a decrease in the expression of lipogenic markers crucial for fat synthesis in the liver (fatty acid synthase, stearoyl-CoA desaturase[ncbi.nlm.nih.gov] Further, abnormal lipid metabolism caused by HF was alleviated by ALP, which was associated with the decreased Stearoyl-CoA desaturase 1 (SCD1), fatty acid synthase (FAS),[ncbi.nlm.nih.gov]

    Missing: thalian diol
  • Fructose

    IQ motif containing GTPase-activating protein 1 (IQGAP1) is a MAPK scaffold that directly regulates the activation of RAF, MEK, and ERK.[ncbi.nlm.nih.gov] […] proliferator-activated receptor-α (PPAR-α) and carnitine palmitoyl transferase-1 (CPT-1), and down-regulating sensor for fatty acids to control-1 (SREBP-1) and stearoyl-CoA desaturase[ncbi.nlm.nih.gov] All the boys revealed the deficient enzyme activity in leukocytes but none of the girls. The liver biopsy was investigated in six patients to confirm the diagnosis.[ncbi.nlm.nih.gov]

    Missing: thalian diol
  • Bacillus Cereus

    The ability to sensitively trace and identify this active toxin is important for food safety.[ncbi.nlm.nih.gov] Several genes involved in fatty acid (FA) metabolism were downregulated in the mutant, including desA and desB encoding FA acyl-lipid desaturases that catalyze the formation[ncbi.nlm.nih.gov] Bacethrombase demonstrated antiplatelet activity, and dose-dependently inhibited the ADP-induced platelet aggregation.[ncbi.nlm.nih.gov]

    Missing: thalian diol
  • Saccharomyces Cerevisiae

    Because sulfate mimics the chemistry of a phosphate group, this structural data suggested that this groove represents the phosphoryl transfer active site.[ncbi.nlm.nih.gov] Overexpression of crtYB (which encodes a bifunctional phytoene synthase and lycopene cyclase) and crtI (phytoene desaturase) from X. dendrorhous was sufficient to enable carotenoid[edepot.wur.nl] A storage period of 6 months is required for hygienic reasons; therefore, estrogenic activity monitoring is of interest.[ncbi.nlm.nih.gov]

    Missing: thalian diol
  • Anaplastic Thyroid Carcinoma

    Here, we show that dl922-947 infection induces PARP activation, and we confirm in vitro and in vivo that PARP inhibition increases dl922-947 replication and oncolytic activity[ncbi.nlm.nih.gov] We investigated the effects of targeted inhibition of stearoyl-CoA desaturase 1 (SCD1), a constituent of fatty acid metabolism overexpressed in ATC.[ncbi.nlm.nih.gov] In the present study, we report that in human ATC tumor tissue samples exist undetectable Notch1 and the active Notch1 intracellular domain could not be detected in ATC-CAL[ncbi.nlm.nih.gov]

    Missing: thalian diol
  • Hepatitis C Virus

    A third of humans carry genetic variants of the ITP pyrophosphatase (ITPase) gene (ITPA) that lead to reduced enzyme activity.[ncbi.nlm.nih.gov] In contrast, expression of the key enzymes of hepatic de novo lipogenesis fatty acid synthase (FASN) and stearoyl-CoA desaturase (SCD-1) was significantly reduced upon oleate[ncbi.nlm.nih.gov] Antiviral activity of the selected plant extract was find out against HCV infected HepG2 cells.[ncbi.nlm.nih.gov]

    Missing: thalian diol
  • Smith Lemli Opitz Syndrome

    Impaired DHCR7 function is associated with a spectrum of congenital malformations, intellectual impairment, epileptiform activity and autism spectrum disorder.[ncbi.nlm.nih.gov] […] in the biosynthesis of cholesterol; 2) the most clinically severe form of the syndrome may be associated with the most inhibited enzyme; and 3) the enzyme lathosterol 5-desaturase[ncbi.nlm.nih.gov] Lathosterolosis is caused by a deficiency in the enzyme sterol 3-beta-hydroxysteroid-delta-5-desaturase which is necessary for the conversion of lathosterol into 7-DHC.[clinicaltrials.gov]

    Missing: thalian diol