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4,383 Possible Causes for activity, glutamate, high affinity, transporter

  • Gemfibrozil

    The high affinity K(m) value was 2.5 microM, which is similar to the K(m) value of gemfibrozil glucuronidation in recombinant UGT2B7 (2.2 microM).[] However, mechanisms by which microglial activation could be controlled are poorly understood.[] […] glutathione, superoxide dismutase, catalase and increase in the level of lipid peroxidation and various serum parameters (creatine phosphokinase, lactate dehydrogenase, serum glutamate[] On the other hand, hOAT1 and hOAT2 did not transport pravastatin.[]

  • Focal Dystonia

    CONCLUSIONS: Because [(11)C]NNC 112 has high affinity for D1-like receptors, very low affinity for D2-like receptors, and minimal sensitivity to endogenous dopamine levels[] RESULTS: BSP and CD patients and healthy controls showed similar activation in the pre-motor, primary motor and primary sensory cortex, whilst basal-ganglia activation was[] The IgG antibody of glutamate receptor δ2 was detected. Ictal and interictal SPECT suggested focal epilepsy in the left frontal cortex.[] Likewise, the timing of peak grasp aperture in relation to the time of hand transport did not differ between patients and controls.[]

  • Melatonin

    High-affinity (Kd 103.7 pm) MT1 melatonin receptor subtype was expressed by the patient's prostate cancer.[] Abstract Head and neck squamous cell carcinoma (HNSCC) clearly involves activation of the Akt mammalian target of rapamycin (mTOR) signalling pathway.[] We performed in vitro assays to assess whether melatonin 1) enhances the antioxidant response element genes (heme-oxygenase 1, (HO-1), glutamate-cysteine ligase (GCLC), NAD[] Here, we show that melatonin MT 1 and MT 2 receptors co-immunoprecipitate with the DA transporter (DAT) in mouse striatal synaptosomes.[]

  • Dopamine

    Compound 15b was considered the lead compound from this analog series due to its high affinity and selectivity for VMAT2. Copyright 2017 Elsevier Ltd.[] Sensitive assay for TYR activity is significant for basic and clinical research.[] KEYWORDS: Cannabinoid; NMDA; dopamine; serotonin; glutamate; schizophrenia; psychosis[] Abstract While dopamine transporter single-photon emission computed tomography (DAT-SPECT) imaging is sensitive and specific when performed in patients with signs or symptoms[]

  • Vitamin E

    However, a high-affinity ligand seemed to be lacking, either in the hepatic recycling of vitamin E or in both the hepatic and the other vitamin E compartments.[] Several factors, including cytokines and chemokines, regulate the development and migration of activated mast cells.[] Vitamin E was covalently linked to multivalent methoxy poly(ethylene glycol)-co-poly(glutamic acid), generating amphiphilic conjugates that could self-assemble into micelles[] Surprisingly, detailed analyses of these cholesterol transporters have revealed that they can also transport vitamin E and vitamin K, providing clues to uncover the molecular[]

  • Corticotropin

    Recently, a CRF-related peptide, termed PD-sauvagine, was isolated from the skin of the frog, Pachymedusa dacnicolor, and validated as a high-affinity ligand for CRF receptor[] Our findings suggest some functional activity even in clinically "silent" adrenocortical adenoma.[] Therefore, this study sought to determine whether EtOH modulates CeA glutamate transmission via activation of CRF signaling.[] In this study, we examined the regulatory effect of CRF on the expression and function of the norepinephrine transporter (NET) in vitro.[]

  • Pentazocine

    In saturation binding studies, the addition of ( )-SKF 10,047 occluded binding of [3H]-( )-pentazocine to high affinity sigma binding sites.[] Both drugs had good antalgic activity, significantly relieving pain in the 3 days of treatment (p 0.01 from baseline).[] A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of: Rhodopsin-like Receptors Secretin-like Receptors Glutamate[] Western blot analysis showed a decrease in biotinylated cell-surface NE transporter (NET) expression after the treatment with (-)-PTZ.[]

  • Citalopram

    S-citalopram is a drug used to treat depression and anxiety by binding to the serotonin transporter with high-affinity, blocking serotonin reuptake.[] BACKGROUND: Evidence has been provided of the anti-proliferative activity of citalopram against some cancer cells.[] Little is known about the acute effects of antidepressant treatments on brain glutamate and gamma-amino-butyric acid (GABA) levels, and their association with clinical response[] The antidepressant drug citalopram displays high-affinity S1 binding and low-affinity S2 binding.[]

  • Fluvoxamine

    Abstract The CYP2D6 enzyme is a capacity-limited high-affinity drug elimination pathway that metabolizes numerous psychiatric medicines.[] AC-AEs were defined as hyperactivity, activation, and disinhibition.[] BACKGROUND: Several lines of evidence implicate abnormalities in glutamate neural transmission in the pathophysiology of mood disorders, including major depressive disorder[] KEYWORDS: Biomarker; Lymphoblast; Major depressive disorder; Serotonin transporter; Ubiquitination[]

  • Atenolol

    OBJECTIVE: β-blockers (BBs) with different pharmacological properties may have heterogeneous effects on sympathetic nervous activity (SNA) and central aortic pressure (CAP[] A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of: Rhodopsin-like Receptors Secretin-like Receptors Glutamate[] Using a panel of human embryonic kidney cell lines stably expressing human organic cation transporter (hOCT) 1-3, human organic anion transporter (hOAT) 1, hOAT3, human multidrug[] METHOD: This was a prospective, randomized, open-label, active-controlled trial in 209 hypertensive patients to evaluate the effect of bisoprolol and atenolol on aortic pulse[]