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15 Possible Causes for activity, guanase

  • Xanthinuria

    Xanthine oxidase activity was virtually absent in the patients' duodenal mucosa, a finding that established the diagnosis of hereditary xanthinuria.[ncbi.nlm.nih.gov] Xanthine continues to accumulate, despite the recycling of hypoxanthine, because of the metabolism of guanine to xanthine by the enzyme guanase (see image below).[emedicine.com] Erythrocyte adenosine deaminase (EC 3.5.4.4) and purine-nucleoside phosphorylase (EC 2.4.2.1) activities of the patients were within the normal ranges.[ncbi.nlm.nih.gov]

  • Ribavirin

    The antiviral activity in vitro was based on cytopathogenicity inhibition and yield reduction.[ncbi.nlm.nih.gov] […] β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent: (purine and pyrimidine precursors/IMP dehydrogenase/Virazole 5′-phosphate/guanase[drugs.com] The data obtained confirm the proposed theory of the ribavirin possible antiviral activity mechanism related with bioisosterism. Copyright 2017 Elsevier Ltd.[ncbi.nlm.nih.gov]

  • Antimetabolite

    In this review, the recent literature describing investigations of the structural and thermodynamic basis for the anticancer activity of three antipyrimidines [1-beta-D-arabinofuranosyl[ncbi.nlm.nih.gov] The guanase and xanthine dehydrogenase/oxidase reactions are depicted in slide 16.5.3 .[watcut.uwaterloo.ca] Abstract 2-Chlorodeoxyadenosine (2-CdA) is unique compared with traditional antimetabolites in that it is equally active against dividing and resting lymphocytes, which may[ncbi.nlm.nih.gov]

  • Disorder of Purine Metabolism

    In comparison with the activity in the brain and liver of an infant of 2 years, the activity of the organs of a fetus of 8 months as well as of an adult tended to be lower[jstage.jst.go.jp] PHOSPHORYLASE, release RIBOSE-1-PHOSPHATE and a purine BASE 17 Purine synthesis product HYPOXANTHINE and GUANINE next form XANTHINE in reactions catalysed by xanthine oxidase and guanase[powershow.com] […] metabolised by several enzymes : Guanine [ edit ] A nuclease frees the nucleotide A nucleotidase creates guanosine Purine nucleoside phosphorylase converts guanosine to guanine Guanase[en.wikipedia.org]

  • Xanthinuria Type 1

    Abstract Two brothers with classical xanthinuria who lacked xanthine dehydrogenase activity were encountered.[ncbi.nlm.nih.gov] Xanthine continues to accumulate, despite the recycling of hypoxanthine, because of the metabolism of guanine to xanthine by the enzyme guanase (see image below).[emedicine.medscape.com] APRT activity was assayed by a non‐radiochemical method in which adenosine monophosphate (AMP) and AMP metabolites produced from a substrate adenine were converted to inosine[doi.org]

  • Disorder of Pyrimidine Metabolism

    In the most common of the hyperuricemic metabolic disorders, deficiency of hypoxanthine phosphoribosyl transferase, the fundamental deficiency in the activity of an enzyme[ncbi.nlm.nih.gov] PHOSPHORYLASE, release RIBOSE-1-PHOSPHATE and a purine BASE 17 Purine synthesis product HYPOXANTHINE and GUANINE next form XANTHINE in reactions catalysed by xanthine oxidase and guanase[powershow.com] Myoadenylate deaminase deficiency may be shown in muscle biopsy samples by histochemical staining or measurement of specific enzymatic activity.[musculoskeletalkey.com]

  • Gout

    Physical activity and cardiorespiratory fitness are not currently recognized as factors related to preventing gout, nor are risk factors for gout in physically active men[ncbi.nlm.nih.gov] Xanthine was generated from guanine by the action of guanase. 2.4. [jstage.jst.go.jp] The more active men were also fitter and leaner, the fitter men were more active and leaner, and the leaner men were more active and more fit.[doi.org]

  • Primary Hypomagnesemia with Secondary Hypocalcemia

    […] is highly similar to TRPM7 (also known as TRP-PLIK), a bifunctional protein that combines calcium- and magnesium-permeable cation channel properties with protein kinase activity[ncbi.nlm.nih.gov] […] relacionados con el diagnstico diagnosis-related group grupos relacionados con el diagnstico diagnostic related groups grupos sanguneos ABO ABO blood groups GSA ABG guanasa guanase[dokumen.tips] […] in the active magnesium absorption is TRPM6.[doi.org]

  • Gouty Arthritis

    METHODS: Two 12-week randomised, multicentre, active-controlled, double-blind, parallel-group core studies with double-blind 12-week extensions (response in acute flare and[ncbi.nlm.nih.gov] Xanthine was generated from guanine by the action of guanase. 2.4. [jstage.jst.go.jp] The more active men were also fitter and leaner, the fitter men were more active and leaner, and the leaner men were more active and more fit.[doi.org]

  • Xanthinuria Type 2

    595 In Vitro and in Vivo Inhibitory Activity of the DifferentiationInducing Agent 605 NHydroxy5Halogeno2Deoxycytidines and Their 5Monophosphates 617 Investigation of Isoenzymes[books.google.de] Xanthine continues to accumulate, despite the recycling of hypoxanthine, because of the metabolism of guanine to xanthine by the enzyme guanase (see image below).[emedicine.medscape.com] Enzyme Activity Test The activity of XOD was determined using a colorimetric XOD activity assay kit from BioVision.[karger.com]

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