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1,217 Possible Causes for activity, high affinity, symporter, thiamine:proton

  • Methimazole

    Besides, albumin interaction experiments denoted high affinity toward the complexes and the calculated binding constants indicate reversible binding to the protein.[ncbi.nlm.nih.gov] Flashcards in Sketchy Pharm: Propylthiouracil, Methimazole, and Levothyroxine Deck (18): Iodide enters the follicular cells through ______________ channels. sodium/iodide symporter[brainscape.com] The catechol moiety of rutin produced the voltammetric peaks via a 2 electron, 2 proton mechanism in the range of 0.0-0.4V (vs. Ag/AgCl).[ncbi.nlm.nih.gov] To investigate whether AhR-activating substances accumulate in patients with endocrine disorders, we tested serum samples for AhR-stimulating activity.[ncbi.nlm.nih.gov]

  • Phenmetrazine

    Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.[drugbank.ca] For example TMA-2 is active, TMMA-2 is not. But the only two known to retain activity are MDMA and plain old MA.[sciencemadness.org] However, in the chemical ionization mass spectrum, the protonated molecular ion at m/z 414 was the base peak.[ncbi.nlm.nih.gov] This effect may be a direct result of peripheral alpha-agonist activity.[inchem.org]

  • Buspirone

    Buspirone, a 5-HT1A partial agonist approved for the treatment of anxiety, has been reported to also bind with high affinity to D3 and D4 receptors.[ncbi.nlm.nih.gov] Our findings suggest that activation of 5-HT 1A receptors depresses human motoneurone excitability.[ncbi.nlm.nih.gov] […] transporter protein were constructed using the crystal structure of the Escherichia coli major facilitator family transporter-LacY and the X-ray structure of the neurotransmitter symporter[ncbi.nlm.nih.gov] METHODS: Between Jan-2007 and Dec-2014, we enrolled 59 patients with FD unresponsive to first-line therapy with proton pump inhibitors and/or domperidone that underwent OBT[ncbi.nlm.nih.gov]

  • Calcitonin

    It is a proof for a CGRP receptor within nucleus accumbens of brain that is different from either the CGRP 1 or CGRP 2 receptor in which it demonstrates similar high-affinity[ncbi.nlm.nih.gov] The data suggest that hydrophobic interactions are more important for CLR activation than other class B GPCRs, providing new insights into the mechanisms of activation of[ncbi.nlm.nih.gov] […] becomes a part of so-called colloid . 2) Iodide uptake and its transport to colloid The uptake of iodine from the blood is mediated by the thyroid iodine pump ( Na /I – symporter[fblt.cz] METHODS: We applied an optimized in vivo human pharmacological proton ( 1 H) magnetic resonance spectroscopy (MRS) protocol (PRESS, repetition time 3000 ms, echo time 37.6[ncbi.nlm.nih.gov]

  • Loop Diuretic

    They inhibited with high affinity in the sequence bumetanide greater than piretanide greater than furosemide.[ncbi.nlm.nih.gov] Its primary site of activity is the thick ascending limb of the loop of Henle, where it blocks active reabsorption of sodium and chloride, resulting in diuresis, natriuresis[ncbi.nlm.nih.gov] As mentioned, loop diuretics act at the level of the ascending henle and inhibit the Na2ClK symporter.[pathwaymedicine.org] […] fluid is required to prevent volume depletion Toxicity : Hypokalemia metabolic alkalosis: Increased delivery of NaCl and water to the collecting duct increases potassium and proton[pharmacology2000.com]

  • Bile Salt

    The antibodies were reactive toward the first extracellular loop of BSEP, were of high affinity, and inhibited transport activity of BSEP, thus causing severe cholestasis.[ncbi.nlm.nih.gov] […] an overview on transcriptional control of these transporters by the key regulatory nuclear receptors and discuss the potential therapeutic role of novel transcriptional activators[ncbi.nlm.nih.gov] Proton pump inhibitors (PPI) can block chemokine production through mechanisms independent of their antisecretory effects.[ncbi.nlm.nih.gov] affinity for bile acids in the gastrointestinal tract, and form complexes with them a disadvantage of colestyramine and colestipol is an unpleasant taste, which can lead[gpnotebook.co.uk]

  • Vasodilation

    These compounds have a high affinity for the A 2A receptor and a long duration of action.[jpet.aspetjournals.org] We report for the first time that the active vasodilator component of cutaneous sympathetic activity in limbs was recorded without any vasoconstrictor component in a patient[ncbi.nlm.nih.gov] Dephosphorylation by myosin light-chain phosphatase and induction of calcium symporters and antiporters that pump calcium ions out of the intracellular compartment both contribute[en.wikipedia.org] The results demonstrate that VIP, NO, adenosine and protons may induce a vasodilation of swimbladder blood vessels.[jeb.biologists.org]

  • Fosinopril

    Taken as a whole, our findings demonstrate that fosinopril is transported intact by PEPT2 and PEPT1, with high-affinity and by a proton-coupled, saturable process.[ncbi.nlm.nih.gov] We conducted a randomized controlled trial to assess the effects of these drugs on plasminogen activator inhibitor-1 (PAI-1) antigen, an inhibitor of fibrinolysis.[ncbi.nlm.nih.gov] Diseases Renal Insufficiency Hydrochlorothiazide Fosinopril Benidipine Antihypertensive Agents Diuretics Natriuretic Agents Physiological Effects of Drugs Sodium Chloride Symporter[clinicaltrials.gov] Epub 2008 Aug 19. [ PubMed:18713951 ] Kind Protein Organism Humans Pharmacological action Unknown Actions Substrate General Function Peptide:proton symporter activity Specific[drugbank.ca]

  • Citalopram

    S-citalopram is a drug used to treat depression and anxiety by binding to the serotonin transporter with high-affinity, blocking serotonin reuptake.[ncbi.nlm.nih.gov] BACKGROUND: Evidence has been provided of the anti-proliferative activity of citalopram against some cancer cells.[ncbi.nlm.nih.gov] […] structural and computational analyses to explain this SAR and demonstrate the potential utility of the newly emerging X-ray structures within the neurotransmitter:sodium Symporter[ncbi.nlm.nih.gov] Using proton magnetic resonance spectroscopy ( 1 H-MRS) we examined longitudinally the effects of citalopram on glutamine/glutamate ratios and GABA levels in the pregenual[ncbi.nlm.nih.gov]

  • Glioma

    affinity and specificity [ 75 ].[intechopen.com] In our present study, we studied the GHET1 expression in glioma and its effects to biological activities of glioma in vitro and vivo studies.[ncbi.nlm.nih.gov] MV-NIS is a more recently constructed MV-Edmonston derivative, with similar backbone to MV-CEA, encoding the sodium iodine symporter gene.[mayo.edu] KEYWORDS: 1H-MRS; Posttreatment radiation effect; Proton magnetic resonance spectroscopy; Radiation necrosis; Recurrent glioma; Tumor recurrence[ncbi.nlm.nih.gov]