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115 Possible Causes for Activity of 2-Oxoacid-Dehydrogenases Decreased, Activity of Mitochondrial Respiratory Complexes Decreased

  • Multiple Mitochondrial Dysfunctions Syndrome Type 1

    Mitochondrial DNA copy numbers are decreased as is the activity of respiratory complex I.[disorders.eyes.arizona.edu] activity of the pyruvate dehydrogenase complex Respiratory failure Ketoacidosis Hyperventilation Hypertension Muscle weakness Episodic ketoacidosis Methylmalonic aciduria[mendelian.co] Hui J, Kirby DM, Thorburn DR, Boneh A (2006) Decreased activities of mitochondrial respiratory chain complexes in non-mitochondrial respiratory chain diseases.[journals.plos.org]

  • Multiple Mitochondrial Dysfunctions Syndrome Type 2
  • Cardiomyopathy

    Biochemical studies showed markedly decreased activities of mitochondrial respiratory chain complexes I and IV with a mild decrease of complex III activity in skeletal and[ncbi.nlm.nih.gov] We describe the clinical, biochemical and molecular investigations of two unrelated boys presenting with fatal infantile cardiomyopathy, lactic acidosis and respiratory failure[ncbi.nlm.nih.gov]

    Missing: Activity of 2-Oxoacid-Dehydrogenases Decreased
  • Zinc Deficiency

    Moreover, hepatic mitochondrial respiratory complexes I, III, IV, and V and hepatic ATP production were decreased by chronic alcohol exposure.[ncbi.nlm.nih.gov] Chronic alcohol feeding decreased peroxisome proliferator-activated receptor gamma coactivator-1-alpha (PGC1α), nuclear respiratory factor 1 (NRF1), mitochondrial transcription[ncbi.nlm.nih.gov] Chronic alcohol exposure increased hepatic triglyceride, free fatty acid, and 4-hydroxynonenal (4HNE) levels; meanwhile hepatic mitochondrial 4HNE level was also increased[ncbi.nlm.nih.gov]

    Missing: Activity of 2-Oxoacid-Dehydrogenases Decreased
  • Constitutional Anemia due to Iron Metabolism Disorder

    decreased activities of multiple respiratory chain complexes based on published criteria.[aetna.com] All subjects had evidence of histochemical and/or biochemical diagnosis of mitochondrial disease in a clinically affected tissue (skeletal muscle, liver, or heart) confirming[aetna.com]

    Missing: Activity of 2-Oxoacid-Dehydrogenases Decreased
  • Kyphoscoliosis

    Decreased activity in muscle mitochondrial respiratory complexes I, III, and IV has been documented. Lactate may be increased in serum and the CSF.[disorders.eyes.arizona.edu]

    Missing: Activity of 2-Oxoacid-Dehydrogenases Decreased
  • Diabetic Neuropathy

    […] defects that decrease the activity of complex I have vastly elevated rates of mitochondrial ·O 2 production ( 14 ).[doi.org] […] defects that decrease the activity of complex I have vastly elevated rates of mitochondrial ·O 2 – production ( 14 ).[web.archive.org] This would ultimately decrease cellular antioxidant activity.[doi.org]

    Missing: Activity of 2-Oxoacid-Dehydrogenases Decreased
  • X-linked Distal Spinal Muscular Atrophy Type 3

    decreased activities of multiple respiratory chain complexes based on published criteria.[aetna.com] All subjects had evidence of histochemical and/or biochemical diagnosis of mitochondrial disease in a clinically affected tissue (skeletal muscle, liver, or heart) confirming[aetna.com]

    Missing: Activity of 2-Oxoacid-Dehydrogenases Decreased
  • Amyotrophic Lateral Sclerosis

    Mitochondria from ALS patients show elevated calcium levels and decreased activity of respiratory chain complexes I and IV, implicating defective energy metabolism [ 112,[doi.org] Mitochondrial DNA mutations have been described in ALS patients [ 117 – 119 ]. 5.[doi.org] Mitochondrial dysfunction Abnormalities in mitochondrial morphology and biochemistry have been reported in sporadic ALS patients, SOD1 transgenic mice and cellular models[doi.org]

    Missing: Activity of 2-Oxoacid-Dehydrogenases Decreased
  • Carbon Monoxide Poisoning

    Cytochrome c oxidase (complex IV of the mitochondrial respiratory chain) activity showed a decrease from 836 /-439 nmol/min.[ncbi.nlm.nih.gov] Cytochrome c oxidase (complex IV of the mitochondrial respiratory chain) activity showed a decrease from 836 439 nmol/min.[doi.org] This gradual decrease in cytochrome c oxidase was found to be statistically significant (P 0.001). Other complex activities showed no any significant variation.[ncbi.nlm.nih.gov]

    Missing: Activity of 2-Oxoacid-Dehydrogenases Decreased

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