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44 Possible Causes for Acute Hemolytic Anemia, Erythrocytes Decreased, Polychromasia in Peripheral Blood Smear

  • Cold Agglutinin Disease

    Conn, Acute Hemolytic Anemia, Cryoglobulinemia and Cold Agglutination, New England Journal of Medicine, 253, 23, (1011), (1955).[] The RBC count will be decreased due to doublet erythrocytes being counted as a single cell, thus resulting in a falsely high MCV. Hematocrit will also be lowered.[] Reticulocytes and Spherocytes The results of the reticulocyte count are usually increased in patients with cold agglutinin disease, with polychromasia in the peripheral blood[]

  • Autoimmune Hemolytic Anemia

    hemolytic anemia, that a revival of interest took place.[] Mechanisms of actions include suppression of autoantibody production, reduction in autoantibody affinity, and decreased destruction of erythrocytes by splenic macrophages,[] Peripheral blood smear showed polychromasia and spherocytosis. Haptoglobin level was 0.06 g/L ( N 0.16-2). Both hemoglobin electrophoresis and G6PD level were normal.[]

  • Congenital Hemolytic Anemia

    Phosphatidylserine internalization in erythrocytes with the mutant ATP11C was decreased 10-fold compared to that of the control, functionally establishing that ATP11C is a[] Laboratory The review of the peripheral blood smear revealed no evidence of the schistocytes or fragmented red cells.[] HEREDITARY-FAMILY) ACUTE HEMOLYTIC ANEMIA CAUSED BY EXOGENOUS HEMOLYTIC FACTORS Acute hemolytic processes, accompanied by severe anemia and jaundice, occur in case of poisoning[]

  • Nonimmune Hemolysis

    Acquired hemolytic anemias are usually acute in nature. Something happens to precipitate the anemia, and it’s a one-time, big hit to the red cells.[] Premature destruction of erythrocytes occurs intravascularly or extravascularly. The etiologies of hemolysis often are categorized as acquired or hereditary.[] blood smear : spherocytes, polychromasia Coombs test : positive Cold agglutinins titer C3 and C4 ; (due to complement activation) Prognosis: spontaneous remission within[]

  • Hemolytic Uremic Syndrome

    It is defined by the triad: acute hemolytic anemia thrombocytopenia acute renal failure The most frequent cause of HUS is a food-borne infection by Shiga toxin (also termed[] Anisocytosis, poikilocytosis, polychromasia, helmet cells, marked schistocytes, and rare platelets were observed in the peripheral blood smear, compatible with microangiopathic[] The hemolytic-uremic syndrome (HUS) is a multisystemic disorder that is characterized by the onset of acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia[]

  • Pyruvate Kinase Deficiency

    decreased erythrocyte pyruvate kinase (PK) activity.[] Peripheral blood smear showed polychromasia, anisocytosis, tear drop cells, fragmented eyrtrocytes, and target cells.[] Abstract Glucose-6-phosphate dehydrogenase (G6PD) deficiency can lead to acute hemolytic anemia, chronic nonspherocytic hemolytic anemia, and neonatal jaundice.[]

  • Uremic Anemia

    [Hemolytic-uremic syndrome: bilateral necrosis of the renal cortex in acute acquired hemolytic anemia].[] […] in 38 hemodialysed patients was decreased and urea, creatinine and middle molecular substances had the effect on decreasing the osmotic resistance of erythrocyte in vitro[] A peripheral blood smear showed red blood cell fragmentation with a few schistocytes (asterisk, 6/high power field) and polychromasia (arrow).[]

  • Atypical Hemolytic Uremic Syndrome

    It encompasses the clinical triad of thrombocytopenia, microangiopathic hemolytic anemia, and acute renal failure, without any association with Shiga toxins.[] Additionally the compound ACH-4471 significantly decreased C3 fragment deposition on paroxysmal nocturnal hemoglobinuria erythrocytes, indicating a reduced potential relative[] Anisocytosis, poikilocytosis, polychromasia, helmet cells, marked schistocytes, and rare platelets were observed in the peripheral blood smear, compatible with microangiopathic[]

  • Anemia due to Glutathione Metabolism Disorder

    Acute hemolytic anemia (AHA) Most G6PD deficiency patients are asymptomatic at baseline, but triggers can cause acute hemolytic anemia.[] Addition of copper to normal erythrocytes led to increased autohemolysis, thermolability of hemoglobin, increased sensitivity to acetylphenylhydrazine, decreased erythrocyte[] The peripheral blood smear post-splenectomy often shows crenated or spiculated spherocytes and marked polychromasia.[]

  • Microangiopathic Hemolytic Anemia

    The patients presented with an acute onset of Coombs negative hemolytic anemia and fragmentocytes in the peripheral blood smear which are typical for MAHA.[] […] than the decrease in number of erythrocytes. hypochromic microcytic anemia any anemia with microcytes that are hypochromic (reduced in size and in hemoglobin content); the[] The peripheral blood smear revealed polychromasia, poikilocytosis, and many schistocytes. Bone marrow biopsy disclosed metastatic carcinoma.[]

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