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18 Possible Causes for Acute Hemolytic Anemia, Globulins Increased, Virus Associated Hemophagocytic Syndrome

  • Sickle Cell Disease

    The disease is characterized by intermittent vaso-occlusive events and chronic hemolytic anemia.[ncbi.nlm.nih.gov] Transfusions are reserved for the treatment of sudden severe anemia due to acute splenic sequestration, para-virus B19 infection, hyper-hemolytic crises, and acute chest syndrome[symptoma.com] Acute and chronic organ dysfunction, chronic hemolytic anemia, and recurrent painful episodes are the main features of sickle cell disease.[epilepsy.com]

  • Infectious Mononucleosis

    , gamma globulin increased less frequently, and beta globulin, which was normal in practically all the cases of infectious mononucleosis, was increased in a considerable number[link.springer.com] Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis.[emedicine.medscape.com] Potential Complications of Infectious Mononucleosis Acute interstitial nephritis Cranial nerve palsies Encephalitis Hemolytic anemia Meningitis Mononeuropathies Myocarditis[aafp.org]

  • Lymphoma

    The erythrocyte sedimentation rate is a sign of activity of the disease and is caused by the increase of the a2-globulins and of the gamma globulins.[lecturio.com] Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com] Lymphoma via Wikipedia Typical findings on laboratory tests are a relative lymphopenia and eosinophilia in the differential blood count, elevation of CRP and LDH, and an increase[lecturio.com]

  • Hodgkin Lymphoma

    Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[emedicine.medscape.com]

  • Chronic Active Hepatitis

    Coombs-positive hemolytic anemia Thrombocytopenia Elevated erythrocyte sedimentation rate Eosinophilia (uncommon) Biopsy Urgent liver biopsy, transjugular if appropriate,[emedicine.medscape.com] Severe chronic active hepatitis, defined as the presence of a fivefold increase in serum aminotransferases and a twofold rise in gamma globulin for at least 10 weeks, is considered[ncbi.nlm.nih.gov] Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[ncbi.nlm.nih.gov]

  • Autoimmune Hepatitis

    .  Less commonly with RA, pernicious anemia, systemic sclerosis, ITP, SLE,coombs positive hemolytic anemia, leucocytoclastic vasculitis, erythema nodosum  40% present with[de.slideshare.net] More than 80% of affected individuals have increased gamma globulin in the blood.[hepatitiscentral.com] Virus-, drug- and lymphoma-associated hemophagocytic syndrome (HPS) was ruled out. Therefore, the patient was diagnosed with autoimmune-associated HPS (AAHS).[ncbi.nlm.nih.gov]

  • Erythema Infectiosum

    […] chronic hemolytic anemia were also analyzed.[ncbi.nlm.nih.gov] IV immune globulin has been used to curtail viremia and increase erythropoiesis in immunocompromised patients with pure RBC aplasia.[merckmanuals.com] Virus-associated hemophagocytic syndrome.[cmr.asm.org]

  • Hepatitis A

    , which can help increase protection to HAV.[liverfoundation.org] hemophagocytic syndrome [3].[ncbi.nlm.nih.gov] […] pancreatitis, aplastic or autoimmune hemolytic anemia, Guillain-Barré syndrome, acute renal failure, or pericarditis may occur in patients with HAV infection. 18, 22 – 27[web.archive.org]

  • Precursor-Cell Lymphoblastic Leukemia

    […] thrombocytopenia with hemolytic anemia.[ncbi.nlm.nih.gov] Late-onset fatal Epstein-Barr virusassociated hemophagocytic syndrome following cord blood cell transplantation for adult acute lymphoblastic leukemia .[ajcp.oxfordjournals.org] anemia and hypogammaglobulinemia Low leukocyte alkaline phosphatase level Philadelphia chromosome–positive in 90% Chronic leukemias have more mature cells than do acute leukemias[merckmanuals.com]

  • Adult Idiopathic Neutropenia

    RESULTS: We found that serum gamma-globulin, IgG and IgG1 levels were all significantly increased in the entire group of patients studied, compared to controls (p CONCLUSION[ncbi.nlm.nih.gov] syndrome Hemophagocytic syndrome associated with an infection Hepatic veno-occlusive disease-immunodeficiency syndrome Hereditary neutrophilia Hereditary periodic fever syndrome[se-atlas.de] Sachan Coombs-positive autoinmune hemolytic anemia in ulcerative colitis Dig Dis Sci, 34 (1999), pp. 1457-1461 [36.] G.G. Shashaty, C.E. Rath, E.J.[elsevier.es]

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