Acute Intermittent Porphyria: Causes & Reasons

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Possible Causes for Acute Intermittent Porphyria

Acute Hepatic Porphyria

Skin lesions can occur in variegate porphyria and hereditary coproporphyria, but do not occur in acute intermittent porphyria [1]. [dermnetnz.org]

Effect of menstrual cycle on acute intermittent porphyria. [scielo.br]

There were 184 patients with acute intermittent porphyria and 61 patients with variegate porphyria. [nature.com]

Acute Intermittent Porphyria

Acute intermittent porphyria is a metabolic disorder rarely seen in prepubertal children. [ncbi.nlm.nih.gov]

Acute Intermittent Porphyria: A Diagnostic Challenge. J Child Neurol. 2011 Dec 21. [Medline]. [emedicine.com]

Further biochemical and molecular testing confirmed the diagnosis of acute intermittent porphyria. [ncbi.nlm.nih.gov]

Porphyria Cutanea Tarda

Primary porphyrias (hereditary enzyme defect) Hepatic porphyrias Acute hepatic porphyrias Acute intermittent porphyria (autosomal dominant) Porphyria variegata (autosomal [amboss.com]

Lesson on Porphyria conditions: Porphyria Cutanea Tarda vs. Acute Intermittent Porphyria. [youtube.com]

[…] with abdominal symptoms and sometimes with neurologic lesions—a clinical picture similar to acute intermittent porphyria combined with light sensitivity. [annals.org]

Peripheral Motor Neuropathy

intermittent porphyria, lead poisoning, diphtheria, multifocal conduction block neuropathy Painful peripheral neuropathy “BADCAP” Diabetes mellitus Alcohol Vitamin B1 or [lifeinthefastlane.com]

Predominantly Motor Neuropathies Guillain-Barre Sydnrome and CIPD Acute intermittant porphyria Lead neuropathy Heritable motor-sensory neuropathies Motor Neuron Disease (neuronopathy [enotes.tripod.com]

intermittent porphyria Persisting nutritional deficiency Dominantly inherited sensory neuropathy CIDP Critical illness polyneuropathy Abnormal metabolic state CIDP HIV/AIDS [aafp.org]

Mental Disorder

This review focuses on three HMD categories: acute, treatable HMDs (urea cycle abnormalities, remethylation disorders, acute intermittent porphyria); chronic, treatable HMDs [dx.doi.org]

[…] pain Acute intermittent porphyria Bipolar disorder Chronic Depression, behavioural disturbances Extra pyramidal symptoms, dysarthria, akinesia Wilson’s disease Confusion, [ncbi.nlm.nih.gov]

PMID 26695173. ^ "Acute Intermittent Porphyria (AIP)". American Porphyria Foundation. 18 February 2009. [en.wikipedia.org]

Carisoprodol

intermittent porphyria Precautions: Use caution in renal or hepatic dysfunction. [rheumaknowledgy.com]

Hypersensitivity to carisoprodol and related compounds (e.g., meprobamate, tybamate); acute intermittent porphyria; children Impaired liver or kidney function, addiction-prone [robholland.com]

Acute intermittent porphyria (a hereditary condition that occurs due to absence of an enzyme ), hypersensitivity, lactation. • • It should be used only for acute treatment [medindia.net]

Familial Mediterranean Fever

These include: surgical emergencies (appendicitis, intussception, perforated ulcer), hereditary angioedema, acute intermittent porphyria, relapsing pancreatitis, systemic [symptoma.com]

Appendicitis, intussusception, perforated peptic ulcer Hereditary angioedema Acute intermittent porphyria Relapsing pancreatitis Systemic lupus erythematosus and vasculitis [clevelandclinicmeded.com]

Differential diagnosis 1 - Surgical emergencies as appendicitis, intussusception, perforated peptic ulcer, etc. 2 - in women, gynecologic disorders. 3 - Acute intermittent [slideshare.net]

Thiopental

• A history of acute intermittent or variegate porphyria. [apps.who.int]

South African) or acute intermittent porphyria. [druglib.com]

Contraindications : Acute intermittent porphyria Liver and kidney disease Severe pulmonary insufficiency. e.g. emphysema· Obstructive sleep apnoea. [doctoralerts.com]

Anxiety Disorder

This review focuses on three HMD categories: acute, treatable HMDs (urea cycle abnormalities, remethylation disorders, acute intermittent porphyria); chronic, treatable HMDs [ncbi.nlm.nih.gov]

View Article Google Scholar Kumar B: Acute intermittent porphyria presenting solely with psychosis: a case report and discussion. [dx.doi.org]

Varied psychiatric manifestations of acute intermittent porphyria. Biol. [ncbi.nlm.nih.gov]

Acute Peritonitis

Non-surgical disease - eg, myocardial infarction, pericarditis, pneumonia, sickle cell crisis, hepatitis, inflammatory bowel disease, opiate withdrawal, typhoid, acute intermittent [patient.info]

porphyria, HIV-associated lymphadenopathy or enteritis. [patient.info]

Acute urinary retention. Abdominal aortic aneurysm. Testicular torsion. [patient.info]

Hepatocellular Carcinoma

Screening for hepatocellular carcinoma in acute intermittent porphyria: a 15-year follow-up in northern Sweden. J Intern Med. 2011;269:538-45. 17. Mitchell EL, Khan Z. [hepatitisc.uw.edu]

Acute and chronic hepatic porphyrias (acute intermittent porphyria, porphyria cutanea tarda, hereditary coproporphyria, variegate porphyria) and tyrosinemia type I are risk [en.wikipedia.org]

intermittent porphyria. [ 10, 16, 17 ] Prognosis of Patients Diagnosed with HCC The overall prognosis for patients diagnosed with HCC in the United States has improved some [hepatitisc.uw.edu]

Guillain-Barré Syndrome

In South Africa (SA), a high incidence of variegate porphyria (VP) is seen as a result of a founder effect, but acute intermittent porphyria (AIP) is also encountered. [ncbi.nlm.nih.gov]

There would be an initial presentation of neuromuscular junction disorder, acute intermittent porphyria, HIV infection, spinal cord disorders, toxic neuropathies and even [ncbi.nlm.nih.gov]

[…] hypophosphataemia Prolonged use of neuromuscular junction blocking drugs Tick paralysis West Nile poliomyelitis Acute intermittent porphyria Functional paralysisMFS, BBE, [vdocuments.net]

Anticonvulsant

Posttraumatic epilepsy and acute intermittent porphyria: effects of phenytoin, carbamazepine, and clonazepam. Neurology 1978;28:824-8. 8. [porphyria.eu]

Treatment of seizures in acute intermittent porphyria: safety and efficacy of gabapentin. Seizure 1998;7:415-6. 3. Krijt J, Krijtova H, Sanitrak J. [porphyria.eu]

Effects of new anticonvulsant medications on porphyrin synthesis in cultured liver cells: potential implications for patients with acute porphyria. [porphyria.eu]

Neurological Disorder

Acute intermittent porphyria can give rise to acute psychosis, often in association with abdominal pain. [doi.org]

Acute Pancreatitis

acute intermittent porphyria and erythropoietic protoporphyria. [en.wikipedia.org]

[…] fold higher risk.[23] Less common causes include pancreatic cancer, pancreatic duct stones,[24] vasculitis (inflammation of the small blood vessels in the pancreas), and porphyria—particularly [en.wikipedia.org]

Aminopyrine

These function tests exhibited a statistically significant correlation with the excretion of porphyrin precursors in patients with acute intermittent porphyria. [ncbi.nlm.nih.gov]

Furthermore, all 12 patients with acute intermittent porphyria who had a liver biopsy because of abnormalities in the aminopyrine breath test or postprandial serum bile acids [ncbi.nlm.nih.gov]

Methsuximide

intermittent porphyria contraindication 234422006 DOID:3890 Disease of liver contraindication 235856003 DOID:409 Neutropenic disorder contraindication 303011007 DOID:1227 [drugcentral.org]

DOID:2848 Systemic lupus erythematosus contraindication 55464009 DOID:9074 Aggressive behavior contraindication 61372001 Kidney disease contraindication 90708001 DOID:2527 Acute [drugcentral.org]

Chlorpropamide

Chlorpropamide is dangerous in patients suffering from acute forms of porphyria, especially variegate porphyria, and to a lesser extent acute intermittent porphyria and hereditary [home.intekom.com]

Acute Intermittent Porphyria — Oral: 25 to 50 mg t.i.d. or q.i.d. [ndrugs.com]

Clorpropamida is also used to treat nausea and vomiting, anxiety before surgery, chronic hiccups, acute intermittent porphyria, and symptoms of tetanus. [ndrugs.com]

Griseofulvin

Griseofulvin may increase attacks of porphyria in patients with acute intermittent porphyria Proper Use of This Medicine Griseofulvin is best taken with or after meals, [mold-survivor.com]

This may precipitate an attack of acute intermittent porphyria in susceptible patients. [pdr.net]

[…] effects affecting the liver Lupus erythematosus or lupus-like diseases--Griseofulvin may worsen lupus symptoms in patients who have lupus erythematosus or lupus-like diseases Porphyria [mold-survivor.com]

Pentobarbital

Potential exacerbation of acute intermittent porphyria or porphyria variegata. e (See Contraindications under Cautions.) [drugs.com]

[…] women who received barbiturates throughout the last trimester of pregnancy. a e Premature neonates are particularly susceptible to the depressant effects of barbiturates. e Porphyria [drugs.com]

Depression

A depression in geology is a landform sunken or depressed below the surrounding area. Depressions form by various mechanisms. Erosion-related: Blowout: a depression created by wind erosion typically in either a partially vegetated sand dune ecosystem or dry soils (such as a post-glacial loess environment). Glacial[…] [en.wikipedia.org]

Sunburn

Sunburns are readily noticeable by their visible signs. These signs include erythema which usually occurs within two to six hours after overexposure. The pain is often so intense that even a thin layer of clothing touching the skin can cause pain. It may also seem like the skin is stiff and can make moving painful or[…] [symptoma.com]

Peripheral Neuropathy

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is characterized clinically by central nervous system dysfunctions. It is unclear whether CADASIL is involved in peripheral neuropathy. A 67-year-old Japanese man with stepwise progression of sensory and motor[…] [ncbi.nlm.nih.gov]

General Anesthesia

General anesthesia is a procedure by which a person is put into sleep like state for the performance of surgery or other painful medical procedures. Although anesthesia was used throughout history, in primitive forms, to help in performing surgeries, the world was introduced to what is general anesthesia for the[…] [anesthesiageneral.com]

Porphyria

Acute intermittent porphyria presents with intermittent abdominal pain that resembles the clinical picture of acute abdomen. [symptoma.com]

(rare in acute intermittent porphyria). [emedicine.medscape.com]

Acute intermittent porphyria incidence ranges from 5-10 per 100,000 (underestimated because of positive cases not being induced and long periods of latency). [web.archive.org]

Rasmussen Syndrome

Seven years later, acute intermittent porphyria was diagnosed as she developed an acute episode of abdominal pain, dark urine, and hyponatremia. [ncbi.nlm.nih.gov]

Acute intermittent porphyria and epilepsy: safety of clonazepam. Epilepsia. 1992 ;33: 108 - 111. [doi.org]

and acute intermittent porphyria. [8] Diagnosis [ edit ] Brain MRI of an 8-year-old female with Rasmussen's encephalitis. [en.wikipedia.org]

Paraplegia

Paraplegia Pronunciation /ˌpærəˈpliːdʒə/ Specialty Physical medicine and rehabilitation Paraplegia is an impairment in motor or sensory function of the lower extremities. The word comes from Ionic Greek (παραπληγίη) "half-stricken". It is usually caused by spinal cord injury or a congenital condition that affects the[…] [en.wikipedia.org]

Delta Aminolevulinate Dehydrase Deficiency

[…] with the following forms of acute hepatic porphyria: delta aminolevulinic acid dehydratase deficiency porphyria (ADP), hereditary coproporphyria (HCP), acute intermittent [invitae.com]

Skin lesions can occur in variegate porphyria and hereditary coproporphyria, but do not occur in acute intermittent porphyria [1]. [dermnetnz.org]

There were 184 patients with acute intermittent porphyria and 61 patients with variegate porphyria. [ncbi.nlm.nih.gov]

Hepatoerythropoietic Porphyria

(rare in acute intermittent porphyria). [emedicine.medscape.com]

Acute porphyrias include acute intermittent porphyria and ALAD deficiency porphyria. [ghr.nlm.nih.gov]

intermittent porphyria Most common, uroporphyrinogen I synthetase, increased dALA synthetase Acute intermittent porphyria lab findings dALA and porphobilinogen in urine, [quizlet.com]

Hereditary Coproporphyria

An acute, primarily motor neuropathy can occur in several forms of porphyria, including acute intermittent porphyria, variegate porphyria, and hereditary coproporphyria, sometimes [ncbi.nlm.nih.gov]

Clinically, patients affected with HCP present similarly to those with other acute porphyrias, such as acute intermittent porphyria (AIP) and variegate porphyria (VP). [en.wikipedia.org]

Acute porphyrias include acute intermittent porphyria and ALAD deficiency porphyria. [ghr.nlm.nih.gov]