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10 Possible Causes for Acute Liver Failure, Direct Bilirubin Increased, Liver Biopsy showing Periportal Necrosis

  • Massive Hepatic Necrosis

    A, intraoperative (POD 0) wedge biopsy of the native liver showed massive hepatic necrosis and periportal ductular structure (HE, 200 ).[nature.com] Early - features of cholangiohepatitis and cholestasis (increased ALP, AST, direct bilirubin, cholesterol); hepatomegaly, jaundice, and pruritis (destructive phase) Late -[quizlet.com] Wilson's disease (hereditary copper accumulation) may infrequently present with acute liver failure.[en.wikipedia.org]

  • Viral Hepatitis

    Parvovirus B19 may be the causative agent in some adult cases of acute non-A-E viral hepatitis and acute liver failure.[ncbi.nlm.nih.gov] The clinical spectrum of acute hepatitis A is wide, ranging from mild case without any noticeable symptoms to severe case with acute liver failure leading to mortality.[ncbi.nlm.nih.gov] Occasionally, acute viral hepatitis progresses to acute liver failure (indicating fulminant hepatitis).[msdmanuals.com]

  • Hepatitis A

    The most striking laboratory findings include increases of serum aminotransferase activities, serum bilirubin (both total and direct), and serum alkaline phosphatase activity[clinchem.org] Hepatitis A related acute liver failure is rare, but is associated with a poor prognosis.[ncbi.nlm.nih.gov] Therefore, he was diagnosed with severe acute liver failure with acute renal failure (ARF) caused by HAV infection.[ncbi.nlm.nih.gov]

  • Isoniazid Hepatitis

    Supportive care for acute liver failure and even liver transplantation may be required.[patient.info] […] acetaminophen-induced acute liver failure.[gi.org] Acute liver failure due to isoniazid.[livertox.nih.gov]

  • Hepatitis B

    liver failure.[ncbi.nlm.nih.gov] The main indications for transplant owing to HBV are now acute liver failure (both acute and acute reactivation on the background of chronic HBV) and HCC.[ncbi.nlm.nih.gov] Severe acute hepatitis B can be treated with an oral antiviral drug but available data on effectiveness are conflicting and those with acute liver failure are candidates for[hepfi.org]

  • Aflatoxicosis

    OBJECTIVES: During January-June 2004, an aflatoxicosis outbreak in eastern Kenya resulted in 317 cases and 125 deaths. We conducted a case-control study to identify risk factors for contamination of implicated maize and, for the first time, quantitated biomarkers associated with acute aflatoxicosis. DESIGN: We[…][ncbi.nlm.nih.gov]

  • Primary Sclerosing Cholangitis

    Finally, although unusual, PSC can present as acute liver failure.[ncbi.nlm.nih.gov] Disease-Associated Acute-On-Chronic Liver Failure , Canadian Journal of Gastroenterology and Hepatology , 10.1155/2018/5108781 , 2018 , (1-7) , (2018) .[doi.org] Hepatic failure - orthotopic liver transplant is indicated for PSC patients with significant cirrhosis or liver failure .[patient.info]

  • Drug-induced Cholestatic Hepatitis

    Liver biopsy showed prominent spotty necrosis and focal confluent necrosis. Portal and mild periportal lymphomononuclear inflammation.[jcdr.net] The clinical presentation of a patient with DILI can vary from an asymptomatic rise in liver enzymes to acute liver failure.[mdedge.com] Supportive care for acute liver failure and even liver transplantation may be required.[patient.info]

  • Primary Biliary Cirrhosis

    Liver biopsy showed lymphocytic and plasmacytic infiltration in the portal and periportal areas, with numerous areas of bridging centrilobular necrosis, indicating AIH.[ncbi.nlm.nih.gov] […] disease 78 terms GI bleeding 46 terms Acute liver injury and acute liver failure 44 terms Non Colorectal GI cancers[quizlet.com] Exposure to anaesthetic gas called halothane may also lead to acute liver failure.[news-medical.net]

  • Mitochondrial DNA Depletion Syndrome 3 Type Hepatocerebral

    […] function tests; Liver tissue shows 80 to 99% depletion of mitochondrial DNA (mtDNA) with decreased activities of mitochondrial-encoded respiratory chain complexes; Biopsy[genome.jp] direct bilirubin and prolonged clotting times.[elsevier.es] Keywords: Acute liver failure, Genetic diagnosis, Hepatocerebral mitochondriopathy, Metabolic disorders.[indianpediatrics.net]

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