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12 Possible Causes for Acute Liver Failure, Globulins Increased, Liver Biopsy showing Periportal Necrosis

  • Massive Hepatic Necrosis

    A, intraoperative (POD 0) wedge biopsy of the native liver showed massive hepatic necrosis and periportal ductular structure (HE, 200 ).[nature.com] Wilson's disease (hereditary copper accumulation) may infrequently present with acute liver failure.[en.wikipedia.org] Anti-HB antibodies were detected after gamma globulin therapy.[link.springer.com]

  • Viral Hepatitis

    Parvovirus B19 may be the causative agent in some adult cases of acute non-A-E viral hepatitis and acute liver failure.[ncbi.nlm.nih.gov] The clinical spectrum of acute hepatitis A is wide, ranging from mild case without any noticeable symptoms to severe case with acute liver failure leading to mortality.[ncbi.nlm.nih.gov] Occasionally, acute viral hepatitis progresses to acute liver failure (indicating fulminant hepatitis).[msdmanuals.com]

  • Hepatitis B

    liver failure.[ncbi.nlm.nih.gov] Household Contact Living with someone who has chronic hepatitis B increases the risk of getting infected.[verywellhealth.com] . • Infusion reactions: When administered IV, do not exceed recommended infusion rates; may increase risk of adverse events.[drugs.com]

  • Hepatitis A

    Hepatitis A related acute liver failure is rare, but is associated with a poor prognosis.[ncbi.nlm.nih.gov] , which can help increase protection to HAV.[liverfoundation.org] Therefore, he was diagnosed with severe acute liver failure with acute renal failure (ARF) caused by HAV infection.[ncbi.nlm.nih.gov]

  • Autoimmune Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Acute liver failure is a rare syndrome with high mortality and is often diagnosed late.[ncbi.nlm.nih.gov] More than 80% of affected individuals have increased gamma globulin in the blood.[hepatitiscentral.com]

  • Bacterial Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Acute-on-chronic liver failure: a new syndrome that will re-classify cirrhosis. Journal of Hepatology 2015;62:S131-143 Acute-on-chronic liver failure .[aeeh.es] Hospitalization is unnecessary in the absence of acute liver failure.[who.int]

  • Chronic Active Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Corticosteroid agents have not proved of benefit in other liver diseases, including alcoholic hepatitis and acute liver failure, and a beneficial effect in primary biliary[ncbi.nlm.nih.gov] Severe chronic active hepatitis, defined as the presence of a fivefold increase in serum aminotransferases and a twofold rise in gamma globulin for at least 10 weeks, is considered[ncbi.nlm.nih.gov]

  • Primary Biliary Cirrhosis

    Liver biopsy showed lymphocytic and plasmacytic infiltration in the portal and periportal areas, with numerous areas of bridging centrilobular necrosis, indicating AIH.[ncbi.nlm.nih.gov] […] disease 78 terms GI bleeding 46 terms Acute liver injury and acute liver failure 44 terms Non Colorectal GI cancers[quizlet.com] […] in testosterone binding globulin levels may occur and total serum testosterone levels may overestimate free testosterone.[doi.org]

  • Hepatitis D

    A comparison of the first and third liver-biopsy specimens showed a significant reduction of portal inflammation (P 0.05) in patients treated with the higher dose of interferon[nejm.org] Complications may include: Chronic active hepatitis Acute liver failure Call your health care provider if you have symptoms of hepatitis B.[medlineplus.gov] In multivariate analysis, lower albumin concentration (p 0.0001) and higher γ-globulin concentration (p 4 ).[doi.org]

  • Chronic Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Clinical Features of Acute Liver Failure.[doi.org] One characteristic laboratory feature of AIH is elevation of serum globulins, in particular, gamma globulin, with a selective increase in IgG, which is generally 1.2-3.0 times[doi.org]

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