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18 Possible Causes for Acute Liver Failure, Hepatomegaly, Liver Biopsy showing Periportal Necrosis

  • Viral Hepatitis

    Three patients presented only jaundice and hepatomegaly; one also had liver failure.[ncbi.nlm.nih.gov] Parvovirus B19 may be the causative agent in some adult cases of acute non-A-E viral hepatitis and acute liver failure.[ncbi.nlm.nih.gov] In the icteric phase, the patients develop jaundice, gastrointestinal disturbance, dark urine, gray-colored stools, right upper quadrant pain, and hepatomegaly.[symptoma.com]

  • Hepatitis A

    The child was deeply icteric and had hepatomegaly. IgM antibodies for hepatitis A virus were positive.[ncbi.nlm.nih.gov] Hepatitis A related acute liver failure is rare, but is associated with a poor prognosis.[ncbi.nlm.nih.gov] The hepatomegaly continues for another 2-12 weeks and thereafter the liver regains its normal function. Hepatitis A is best diagnosed serologically.[symptoma.com]

  • Hepatitis B

    liver failure.[ncbi.nlm.nih.gov] The main indications for transplant owing to HBV are now acute liver failure (both acute and acute reactivation on the background of chronic HBV) and HCC.[ncbi.nlm.nih.gov] Severe acute hepatitis B can be treated with an oral antiviral drug but available data on effectiveness are conflicting and those with acute liver failure are candidates for[hepfi.org]

  • Massive Hepatic Necrosis

    Hepatic involvement is a common finding in cytomegalovirus mononucleosis as manifested by mild hepatomegaly, consistent increases in serum transaminase activity, and variable[annals.org] A, intraoperative (POD 0) wedge biopsy of the native liver showed massive hepatic necrosis and periportal ductular structure (HE, 200 ).[nature.com] Wilson's disease (hereditary copper accumulation) may infrequently present with acute liver failure.[en.wikipedia.org]

  • Primary Sclerosing Cholangitis

    Hepatomegaly (may also have splenomegaly at presentation). Later stages: signs of cirrhosis, portal hypertension or hepatic failure.[patient.info] Finally, although unusual, PSC can present as acute liver failure.[ncbi.nlm.nih.gov] Liver disease other than PSC was defined as autoimmune hepatitis, hepatitis, hepatomegaly, liver failure, cirrhosis, portal hypertension, cholangiocarcinoma, or hepatobiliary[ncbi.nlm.nih.gov]

  • Isoniazid Hepatitis

    Budd–Chiari syndrome may sometimes mimic DILI, and thus it should be considered, especially if tender hepatomegaly and/or ascites are evident.[gi.org] Supportive care for acute liver failure and even liver transplantation may be required.[patient.info] Acute liver failure due to isoniazid.[livertox.nih.gov]

  • Aflatoxicosis

    Symptoms include hepatomegaly, abdominal discomfo rt, anorexia, malaise, jaundice and oedema of legs, face and trunk.[aspergillus.org.uk] The affected liver showed hepatomegaly, paleness, wide areas of hemorrhages and necrosis.[khartoumspace.uofk.edu] Patients will appear ill with fever, jaundice, nausea, vomiting, abdominal pain, and hemorrhagic diathesis, hepatomegaly, and elevated liver function tests.[visualdx.com]

  • Autoimmune Hepatitis

    CT Nonspecific, ranging from normal to hepatomegaly and cirrhosis.[radiopaedia.org] In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Acute liver failure is a rare syndrome with high mortality and is often diagnosed late.[ncbi.nlm.nih.gov]

  • Bacterial Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Acute-on-chronic liver failure: a new syndrome that will re-classify cirrhosis. Journal of Hepatology 2015;62:S131-143 Acute-on-chronic liver failure .[aeeh.es] Hospitalization is unnecessary in the absence of acute liver failure.[who.int]

  • Primary Biliary Cirrhosis

    The multifactorial analysis identified bilirubinemia and hepatomegaly as independent predictive variables.[nejm.org] Liver biopsy showed lymphocytic and plasmacytic infiltration in the portal and periportal areas, with numerous areas of bridging centrilobular necrosis, indicating AIH.[ncbi.nlm.nih.gov] […] disease 78 terms GI bleeding 46 terms Acute liver injury and acute liver failure 44 terms Non Colorectal GI cancers[quizlet.com]

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