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12 Possible Causes for Acute Liver Failure, Hypoglycemia, Liver Biopsy showing Periportal Necrosis

  • Massive Hepatic Necrosis

    A, intraoperative (POD 0) wedge biopsy of the native liver showed massive hepatic necrosis and periportal ductular structure (HE, 200 ).[nature.com] Wilson's disease (hereditary copper accumulation) may infrequently present with acute liver failure.[en.wikipedia.org] Secretion of the following: insulin-like substance -- hypoglycemia erythropoeitin-like substance -- polycythemia PTH-like substance -- hypercalcemia Fibrolamellar Hepatocellular[quizlet.com]

  • Viral Hepatitis

    Parvovirus B19 may be the causative agent in some adult cases of acute non-A-E viral hepatitis and acute liver failure.[ncbi.nlm.nih.gov] The clinical spectrum of acute hepatitis A is wide, ranging from mild case without any noticeable symptoms to severe case with acute liver failure leading to mortality.[ncbi.nlm.nih.gov] Occasionally, acute viral hepatitis progresses to acute liver failure (indicating fulminant hepatitis).[msdmanuals.com]

  • Isoniazid Hepatitis

    Supportive care for acute liver failure and even liver transplantation may be required.[patient.info] […] acetaminophen-induced acute liver failure.[gi.org] Acute liver failure due to isoniazid.[livertox.nih.gov]

  • Aflatoxicosis

    Hypoglycemia, hyperlipidemia, and depletion of lymphocytes accompanied these lesions.[ncbi.nlm.nih.gov]

  • Primary Biliary Cirrhosis

    Liver biopsy showed lymphocytic and plasmacytic infiltration in the portal and periportal areas, with numerous areas of bridging centrilobular necrosis, indicating AIH.[ncbi.nlm.nih.gov] […] disease 78 terms GI bleeding 46 terms Acute liver injury and acute liver failure 44 terms Non Colorectal GI cancers[quizlet.com] A 46-year-old man with type 1 diabetes (age of onset 26 years) was admitted into our hospital due to poor glycemic control (HbA 1c 11.3%) with severe daily hypoglycemia and[care.diabetesjournals.org]

  • Drug-induced Cholestatic Hepatitis

    Liver biopsy showed prominent spotty necrosis and focal confluent necrosis. Portal and mild periportal lymphomononuclear inflammation.[jcdr.net] The clinical presentation of a patient with DILI can vary from an asymptomatic rise in liver enzymes to acute liver failure.[mdedge.com] ., 1629 Hypocholesterolemic agents, 1961: July, 935-959 1695 Hypogammaglobulinemia, relation to infection in chronic lymphocytic leukemia, 1961: May, 603 Hypoglycemia, dizziness[kundoc.com]

  • Chronic Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Clinical Features of Acute Liver Failure.[doi.org] Despite advances in intensive care management, mortality continues to be high (40–80%) and is partly related to ALF's complications, such as cerebral edema, sepsis, hypoglycemia[doi.org]

  • Generalized Lipodystrophy

    Hepatomegaly was noticed, and histological examination of a liver biopsy specimen suggested severe hepatic steatosis and periportal necrosis.[ncbi.nlm.nih.gov] […] disease and cirrhosis K72.00 - K72.01 Acute and subacute hepatic failure without/with coma K73.0 - K73.9 Chronic hepatitis K75.0 - K76.9 Other diseases of liver The above[aetna.com] ADVERSE REACTIONS: Most common adverse reactions ( 10%) in clinical trials were headache, hypoglycemia, decreased weight, and abdominal pain.[myaleptpro.com]

  • Iron Poisoning

    Liver biopsy in a patient with hepatotoxicity will show hepatocellular necrosis in the periportal hepatocytes (Zone 1).[meducator3.net] Nine progressed to shock and/or impaired consciousness; two had acute liver failure.[ncbi.nlm.nih.gov] The profound damage to the liver results in: hypoglycemia, hyperammonemia, coagulation defects, and hepatic encephalopathy occurs in the context of fulminant liver failure[medicinespecifics.com]

  • Chronic Active Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Corticosteroid agents have not proved of benefit in other liver diseases, including alcoholic hepatitis and acute liver failure, and a beneficial effect in primary biliary[ncbi.nlm.nih.gov] Other serious, and also rare, consequences of acute viral hepatitis are aplastic anemia (which can be fatal), pancreatitis, hypoglycemia, and polyarteritis, a serious inflammation[skylinefamilypractice.net]

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