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14 Possible Causes for Acute Liver Failure, Intrahepatic Cholestasis, Liver Biopsy showing Periportal Necrosis

  • Viral Hepatitis

    Parvovirus B19 may be the causative agent in some adult cases of acute non-A-E viral hepatitis and acute liver failure.[ncbi.nlm.nih.gov] Oral S-adenosylmethionine in the symptomatic treatment of intrahepatic cholestasis. A double-blind, placebo-controlled study. Gastroenterology 1990;99:211 - 215.[cancercarewny.com] The clinical spectrum of acute hepatitis A is wide, ranging from mild case without any noticeable symptoms to severe case with acute liver failure leading to mortality.[ncbi.nlm.nih.gov]

  • Hepatitis A

    Hepatitis A related acute liver failure is rare, but is associated with a poor prognosis.[ncbi.nlm.nih.gov] We speculate that this compound ABCB4-ABCB11 genotype led to a severe intrahepatic cholestasis in the setting of HAV infection.[ncbi.nlm.nih.gov] Prolonged intrahepatic cholestasis secondary to acute hepatitis A. Annals of internal medicine. 1984;101(5):635-637. 13. Schiff ER.[cdc.gov]

  • Hepatitis B

    liver failure.[ncbi.nlm.nih.gov] The main indications for transplant owing to HBV are now acute liver failure (both acute and acute reactivation on the background of chronic HBV) and HCC.[ncbi.nlm.nih.gov] Severe acute hepatitis B can be treated with an oral antiviral drug but available data on effectiveness are conflicting and those with acute liver failure are candidates for[hepfi.org]

  • Massive Hepatic Necrosis

    A, intraoperative (POD 0) wedge biopsy of the native liver showed massive hepatic necrosis and periportal ductular structure (HE, 200 ).[nature.com] Wilson's disease (hereditary copper accumulation) may infrequently present with acute liver failure.[en.wikipedia.org] Schmid M, Hefti M, et al: Benign post-operative intrahepatic cholestasis. New Eng J Med 272:545, 1961 Google Scholar 10.[link.springer.com]

  • Isoniazid Hepatitis

    Supportive care for acute liver failure and even liver transplantation may be required.[patient.info] […] acetaminophen-induced acute liver failure.[gi.org] Acute liver failure due to isoniazid.[livertox.nih.gov]

  • Primary Sclerosing Cholangitis

    Finally, although unusual, PSC can present as acute liver failure.[ncbi.nlm.nih.gov] Intrahepatic Cholestasis of Pregnancy Intrahepatic cholestasis of pregnancy (ICP) can occur in the second or third trimester.[clevelandclinicmeded.com] Disease-Associated Acute-On-Chronic Liver Failure , Canadian Journal of Gastroenterology and Hepatology , 10.1155/2018/5108781 , 2018 , (1-7) , (2018) .[doi.org]

  • Drug-induced Cholestatic Hepatitis

    Liver biopsy showed prominent spotty necrosis and focal confluent necrosis. Portal and mild periportal lymphomononuclear inflammation.[jcdr.net] The clinical presentation of a patient with DILI can vary from an asymptomatic rise in liver enzymes to acute liver failure.[mdedge.com] Description Cholestasis is caused by obstruction within the liver (intrahepatic) or outside the liver (extrahepatic).[medical-dictionary.thefreedictionary.com]

  • Primary Biliary Cirrhosis

    Liver biopsy showed lymphocytic and plasmacytic infiltration in the portal and periportal areas, with numerous areas of bridging centrilobular necrosis, indicating AIH.[ncbi.nlm.nih.gov] […] disease 78 terms GI bleeding 46 terms Acute liver injury and acute liver failure 44 terms Non Colorectal GI cancers[quizlet.com] Abstract Primary biliary cirrhosis (PBC) is characterized by progressive nonsuppurative destruction of small bile ducts, resulting in intrahepatic cholestasis, fibrosis and[ncbi.nlm.nih.gov]

  • Chronic Active Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Corticosteroid agents have not proved of benefit in other liver diseases, including alcoholic hepatitis and acute liver failure, and a beneficial effect in primary biliary[ncbi.nlm.nih.gov] Evaluate for signs of acute liver failure by assessing mentation.[clinicaladvisor.com]

  • Autoimmune Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Acute liver failure is a rare syndrome with high mortality and is often diagnosed late.[ncbi.nlm.nih.gov] cholestasis (bilirubinostasis) Syncytial multinucleated giant cells: AIH is the most common cause (30%) of postinfantile giant cell hepatitis, which is rare in adults (0.1[pathologyoutlines.com]

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