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14 Possible Causes for Acute Liver Failure, Liver Biopsy showing Periportal Necrosis, Liver Tenderness

  • Massive Hepatic Necrosis

    A, intraoperative (POD 0) wedge biopsy of the native liver showed massive hepatic necrosis and periportal ductular structure (HE, 200 ).[nature.com] Wilson's disease (hereditary copper accumulation) may infrequently present with acute liver failure.[en.wikipedia.org] The liver was palpable 8 cm below the right costal margin and was not tender.[nap.edu]

  • Viral Hepatitis

    Parvovirus B19 may be the causative agent in some adult cases of acute non-A-E viral hepatitis and acute liver failure.[ncbi.nlm.nih.gov] Physical exam Assessment of the patient may yield remarkable findings such as jaundice, scleral icterus, and an enlarged and tender liver.[symptoma.com] Viral hepatitis is an infection by a virus that primarily affects the liver. The liver is inflamed and becomes tender and swollen.[hepatitiscentral.com]

  • Isoniazid Hepatitis

    Supportive care for acute liver failure and even liver transplantation may be required.[patient.info] […] acetaminophen-induced acute liver failure.[gi.org] Acute liver failure due to isoniazid.[livertox.nih.gov]

  • Hepatitis B

    liver failure.[ncbi.nlm.nih.gov] The tenderness in the liver region may lead to consideration of hepatic Amoebiasis or Typhoid.[tmb.ie] The liver may also be enlarged and tender. Fulminant hepatitis is a severe but very rare form of acute hepatitis .[verywellhealth.com]

  • Hepatitis A

    Hepatitis A related acute liver failure is rare, but is associated with a poor prognosis.[ncbi.nlm.nih.gov] Hepatitis A is a viral infection of the liver. The liver becomes inflamed, tender, and swollen. How does it occur? Hepatitis A is caused by the hepatitis A virus.[web.archive.org] For instance, he might find that you have: A swollen liver and spleen Tenderness in the right upper side of your belly Does Hepatitis A Always Cause Symptoms?[webmd.com]

  • Aflatoxicosis

    Investigations showed abnormal liver function tests, pancytopenia and elevated serum levels of aflatoxins.[ncbi.nlm.nih.gov] Examination revealed a very ill looking pale patient with abdominal distension, tenderness and rectal bleeding and easy bruisability.[ncbi.nlm.nih.gov]

  • Bacterial Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Acute-on-chronic liver failure: a new syndrome that will re-classify cirrhosis. Journal of Hepatology 2015;62:S131-143 Acute-on-chronic liver failure .[aeeh.es] You will have a physical exam to look for: Enlarged and tender liver Fluid in the abdomen (ascites) Yellowing of the skin You may have lab tests to diagnose and monitor your[medlineplus.gov]

  • Chronic Active Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Corticosteroid agents have not proved of benefit in other liver diseases, including alcoholic hepatitis and acute liver failure, and a beneficial effect in primary biliary[ncbi.nlm.nih.gov] It starts with acute symptoms in 30% of the cases with jaundice, fever, malaise, liver tenderness, like an acute viral hepatitis.[meddean.luc.edu]

  • Primary Sclerosing Cholangitis

    Finally, although unusual, PSC can present as acute liver failure.[ncbi.nlm.nih.gov] Depending upon how far the disease has progressed and the effect on liver function, physical examination may reveal an enlarged liver , tenderness in the right upper quadrant[rxlist.com] Disease-Associated Acute-On-Chronic Liver Failure , Canadian Journal of Gastroenterology and Hepatology , 10.1155/2018/5108781 , 2018 , (1-7) , (2018) .[doi.org]

  • Autoimmune Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Acute liver failure is a rare syndrome with high mortality and is often diagnosed late.[ncbi.nlm.nih.gov] It starts with acute symptoms in 30% of the cases with jaundice, fever, malaise, liver tenderness, like an acute viral hepatitis.[meddean.luc.edu]

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