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18 Possible Causes for Acute Liver Failure, Liver Biopsy showing Periportal Necrosis, Malaise

  • Viral Hepatitis

    Parvovirus B19 may be the causative agent in some adult cases of acute non-A-E viral hepatitis and acute liver failure.[ncbi.nlm.nih.gov] She was admitted to the hospital with a history of general malaise and nausea of 5 days duration.[ncbi.nlm.nih.gov] This is followed by the prodromal period, which is characterized by acute manifestations such as fatigue, malaise, fever, anorexia, nausea, emesis, abdominal pain, urticaria[symptoma.com]

  • Hepatitis A

    Hepatitis A related acute liver failure is rare, but is associated with a poor prognosis.[ncbi.nlm.nih.gov] A 25-year-old Japanese man was admitted with general malaise and fever, which had developed 12 days after coming back to Japan from Indonesia.[ncbi.nlm.nih.gov] […] related to HAV have been described, affecting the heart, bone marrow, blood vessels, and other tissues.A 10-year-old boy from a rural area presented with a 15-day history of malaise[ncbi.nlm.nih.gov]

  • Hepatitis B

    liver failure.[ncbi.nlm.nih.gov] HBV reactivation may present as acute hepatitis with symptoms of malaise and fatigue; the average ALT elevation is 300 IU/L but may reach into the thousands.[web.archive.org] Patients might report mild flu-like symptoms such as anorexia, myalgia, nausea, vomiting, fatigue, malaise and low-grade fevers, Ali said.[web.archive.org]

  • Massive Hepatic Necrosis

    A, intraoperative (POD 0) wedge biopsy of the native liver showed massive hepatic necrosis and periportal ductular structure (HE, 200 ).[nature.com] Wilson's disease (hereditary copper accumulation) may infrequently present with acute liver failure.[en.wikipedia.org] A 33-year-old previously healthy man had a 2-week history of fever, malaise, night FULL TEXT[annals.org]

  • Isoniazid Hepatitis

    Supportive care for acute liver failure and even liver transplantation may be required.[patient.info] A prodromal period characterized by fatigue, weakness, anorexia, and malaise was noted in all patients before the appearance of jaundice.[annals.org] Patients should be instructed to report immediately any of the prodromal symptoms of hepatitis, such as fatigue, weakness, malaise, anorexia, nausea or vomiting.[rxmed.com]

  • Primary Sclerosing Cholangitis

    Finally, although unusual, PSC can present as acute liver failure.[ncbi.nlm.nih.gov] Symptoms of PSC include intermittent malaise, pruritus, fever, chills, night sweats, and right upper abdominal quadrant pain.[e-guide.ecco-ibd.eu] In early stages, unspecific manifestations such as fever, fatigue, pruritus, malaise, abdominal pain, and weight loss are reported, however about 40-50% of patients may be[orpha.net]

  • Autoimmune Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Acute liver failure is a rare syndrome with high mortality and is often diagnosed late.[ncbi.nlm.nih.gov] It starts with acute symptoms in 30% of the cases with jaundice, fever, malaise, liver tenderness, like an acute viral hepatitis.[meddean.luc.edu]

  • Aflatoxicosis

    Symptoms include hepatomegaly, abdominal discomfo rt, anorexia, malaise, jaundice and oedema of legs, face and trunk.[aspergillus.org.uk]

  • Bacterial Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Acute-on-chronic liver failure: a new syndrome that will re-classify cirrhosis. Journal of Hepatology 2015;62:S131-143 Acute-on-chronic liver failure .[aeeh.es] In the early stages: tiredness, general malaise, slight fever nausea, poor appetite, changes in taste perception pressure or pain below the right ribs caused by an enlarged[netdoctor.co.uk]

  • Chronic Active Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Corticosteroid agents have not proved of benefit in other liver diseases, including alcoholic hepatitis and acute liver failure, and a beneficial effect in primary biliary[ncbi.nlm.nih.gov] A 56-year-old Saudi male was admitted with abnormal liver chemistry values and a 5-month history of lethargy, malaise, anorexia, and jaundice.[ncbi.nlm.nih.gov]

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