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12 Possible Causes for Acute Liver Failure, Liver Biopsy showing Periportal Necrosis, Obstructive Jaundice

  • Viral Hepatitis

    Parvovirus B19 may be the causative agent in some adult cases of acute non-A-E viral hepatitis and acute liver failure.[ncbi.nlm.nih.gov] Severe cholestatic jaundice and right upper quadrant abdominal pain may occur in elderly patients.[doi.org] The clinical spectrum of acute hepatitis A is wide, ranging from mild case without any noticeable symptoms to severe case with acute liver failure leading to mortality.[ncbi.nlm.nih.gov]

  • Hepatitis A

    Hepatitis A related acute liver failure is rare, but is associated with a poor prognosis.[ncbi.nlm.nih.gov] Rarely, a prolonged cholestatic jaundice lasting about 10 weeks can be seen.[clinicaladvisor.com] Therefore, he was diagnosed with severe acute liver failure with acute renal failure (ARF) caused by HAV infection.[ncbi.nlm.nih.gov]

  • Hepatitis B

    liver failure.[ncbi.nlm.nih.gov] The main indications for transplant owing to HBV are now acute liver failure (both acute and acute reactivation on the background of chronic HBV) and HCC.[ncbi.nlm.nih.gov] Severe acute hepatitis B can be treated with an oral antiviral drug but available data on effectiveness are conflicting and those with acute liver failure are candidates for[hepfi.org]

  • Massive Hepatic Necrosis

    A, intraoperative (POD 0) wedge biopsy of the native liver showed massive hepatic necrosis and periportal ductular structure (HE, 200 ).[nature.com] Wilson's disease (hereditary copper accumulation) may infrequently present with acute liver failure.[en.wikipedia.org] […] hx of recent intensified drinking, RUQ pain, jaundice, leukocytosis, (PMN), modest elevation of AST and elevated alkaline phosphate ( resembles obstructive jaundice).[quizlet.com]

  • Primary Sclerosing Cholangitis

    Finally, although unusual, PSC can present as acute liver failure.[ncbi.nlm.nih.gov] A 46-year-old woman was admitted to our hospital with obstructive jaundice. The liver function tests demonstrated increased serum liver enzyme levels.[ncbi.nlm.nih.gov] The post-operative course, complicated by cholestatic jaundice, and subsequent clinical complications are described, showing how the diagnosis of sclerosing cholangitis was[ncbi.nlm.nih.gov]

  • Isoniazid Hepatitis

    Supportive care for acute liver failure and even liver transplantation may be required.[patient.info] Cholestatic jaundice caused by ethambutol. Br Med J 1986; 292: 866.[livertox.nih.gov] Pyrrolizidine alkaloids typically have been associated with sinusoidal obstruction syndrome ( 69, 70, 71, 72, 73, 74 ).[gi.org]

  • Drug-induced Cholestatic Hepatitis

    Liver biopsy showed prominent spotty necrosis and focal confluent necrosis. Portal and mild periportal lymphomononuclear inflammation.[jcdr.net] Conclusions Our patient’s case illustrates a rare DILI due to cefuroxime, presenting as prolonged cholestatic jaundice following “successful” therapeutic ERCP for an obstructing[jmedicalcasereports.biomedcentral.com] The clinical presentation of a patient with DILI can vary from an asymptomatic rise in liver enzymes to acute liver failure.[mdedge.com]

  • Autoimmune Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] We present a rare case of a 52-year-old male who was admitted with obstructive jaundice and itchy skin.[ncbi.nlm.nih.gov] Acute liver failure is a rare syndrome with high mortality and is often diagnosed late.[ncbi.nlm.nih.gov]

  • Primary Biliary Cirrhosis

    Liver biopsy showed lymphocytic and plasmacytic infiltration in the portal and periportal areas, with numerous areas of bridging centrilobular necrosis, indicating AIH.[ncbi.nlm.nih.gov] […] disease 78 terms GI bleeding 46 terms Acute liver injury and acute liver failure 44 terms Non Colorectal GI cancers[quizlet.com] ) can be caused by obstructive jaundice, a condition in which bile flow from the liver ducts is blocked.[dovemed.com]

  • Chronic Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Clinical Features of Acute Liver Failure.[doi.org] […] or evidence of significant extrahepatic biliary obstruction, significant coagulopathies or serious diseases involving other organs such as severe congestive heart failure[doi.org]

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