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10 Possible Causes for Acute Liver Failure, Liver Biopsy showing Periportal Necrosis, Yellow Discoloration of the Skin

  • Viral Hepatitis

    Parvovirus B19 may be the causative agent in some adult cases of acute non-A-E viral hepatitis and acute liver failure.[ncbi.nlm.nih.gov] The most notable symptom of acute viral hepatitis is jaundice, which is a yellow discoloration of the skin and the whites of the eyes.[patients.gi.org] discoloration of the skin and the whites of the eyes ( jaundice ).[labtestsonline.org]

  • Hepatitis A

    Hepatitis A related acute liver failure is rare, but is associated with a poor prognosis.[ncbi.nlm.nih.gov] The most common symptoms are as follows: Nausea Vomiting Diarrhea, especially in children Low-grade fever Loss of appetite Rash Tiredness, fatigue Jaundice - A yellow discoloration[web.archive.org] A hepatitis infection is also associated with jaundice, a yellow discoloration of the skin and a yellowish color to the whites of the eyes.[healthychildren.org]

  • Hepatitis B

    liver failure.[ncbi.nlm.nih.gov] Jaundice (a yellow discoloration of eyes and skin), which is usually a sign of liver damage, may not occur.[web.archive.org] The main indications for transplant owing to HBV are now acute liver failure (both acute and acute reactivation on the background of chronic HBV) and HCC.[ncbi.nlm.nih.gov]

  • Aflatoxicosis

    OBJECTIVES: During January-June 2004, an aflatoxicosis outbreak in eastern Kenya resulted in 317 cases and 125 deaths. We conducted a case-control study to identify risk factors for contamination of implicated maize and, for the first time, quantitated biomarkers associated with acute aflatoxicosis. DESIGN: We[…][ncbi.nlm.nih.gov]

  • Primary Sclerosing Cholangitis

    Finally, although unusual, PSC can present as acute liver failure.[ncbi.nlm.nih.gov] Affected individuals may have no symptoms or may experience signs and symptoms of liver disease such as yellow discoloration of the skin and eyes, itching, and abdominal pain[en.wikipedia.org] Disease-Associated Acute-On-Chronic Liver Failure , Canadian Journal of Gastroenterology and Hepatology , 10.1155/2018/5108781 , 2018 , (1-7) , (2018) .[doi.org]

  • Hepatitis D

    A comparison of the first and third liver-biopsy specimens showed a significant reduction of portal inflammation (P 0.05) in patients treated with the higher dose of interferon[nejm.org] Complications may include: Chronic active hepatitis Acute liver failure Call your health care provider if you have symptoms of hepatitis B.[medlineplus.gov] Possible Complications Complications may include: Chronic active hepatitis Acute liver failure When to Contact a Medical Professional Call your health care provider if you[umms.org]

  • Autoimmune Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Acute liver failure is a rare syndrome with high mortality and is often diagnosed late.[ncbi.nlm.nih.gov] discoloration of the skin and the whites of the eyes ( jaundice ).[labtestsonline.org]

  • Drug-induced Cholestatic Hepatitis

    Liver biopsy showed prominent spotty necrosis and focal confluent necrosis. Portal and mild periportal lymphomononuclear inflammation.[jcdr.net] The clinical presentation of a patient with DILI can vary from an asymptomatic rise in liver enzymes to acute liver failure.[mdedge.com] discoloration of the skin (jaundice), dark urine, and pale stools.[medical-dictionary.thefreedictionary.com]

  • Chronic Hepatitis

    In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Clinical Features of Acute Liver Failure.[doi.org] But over time, they can experience the following: tiredness weight loss nausea abdominal pain severe itching jaundice (yellow discoloration of the skin and eyes) Eventually[hepc.liverfoundation.org]

  • Primary Biliary Cirrhosis

    Liver biopsy showed lymphocytic and plasmacytic infiltration in the portal and periportal areas, with numerous areas of bridging centrilobular necrosis, indicating AIH.[ncbi.nlm.nih.gov] […] disease 78 terms GI bleeding 46 terms Acute liver injury and acute liver failure 44 terms Non Colorectal GI cancers[quizlet.com] When PBC is very severe, it can lead to yellow discoloration of the skin (jaundice).[rarediseases.org]

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