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11 Possible Causes for Acute Respiratory Failure, Presynaptic Defect at the Neuromuscular Junction

  • Lambert Eaton Myasthenic Syndrome

    The patient presented with acute respiratory failure, making identification and management of her illness challenging.[ncbi.nlm.nih.gov] A c.923C T variant affecting an adjacent residue (p.Pro308Leu) produced a presynaptic neuromuscular junction defect and a dominant hereditary motor neuropathy in a second[ncbi.nlm.nih.gov] However, rare cases of severe respiratory compromise or respiratory failure have been reported in patients with LEMS.[medscape.com]

  • Infantile Botulism

    Abstract Infantile botulism is a recently recognized cause of acute hypotonic paresis and respiratory failure in young infants.[ncbi.nlm.nih.gov] EMG studies were suggestive of presynaptic neuromuscular junction defect. Motor unit potentials were of small amplitude and brief duration with increased polyphasia.[pediatricneurologybriefs.com] […] tetraparesis and respiratory failure hypotonia head lag ptosis reduced facial expression reduced suck and swallow loss of reflexes slowly improves after weeks Adult intestinal[lifeinthefastlane.com]

  • Idiopathic Camptocormia

    Respiratory Failure and Myoglobinuria 539 Case 86 A Uremic Man with Proximal Muscle Weakness 545 Case 87 A Woman with Weakness Elevated Cholesterol and Serum Creatine Kinase[books.google.de] Botulinum toxin : Botulinum toxin acts by producing chemodenervation and local paralysis in the injected muscle due to presynaptic neuromuscular junction defect.[ijmr.org.in] Swelling in the Neck 522 Case 83 A Woman with Muscle Pains and Dark Urine 526 Case 84 A Woman with Progressive Proximal Muscle Weakness 533 Case 85 A Sedentary Man with Acute[books.google.de]

  • Familial Infantile Myasthenia

    Acute respiratory failure can be the product of any of a great number of muscular, neuromuscular, and neurologic causes.[ncbi.nlm.nih.gov] Thus, a presynaptic defect of acetylcholine resynthesis, packaging or mobilisation was proposed ( 8, 9, 16 ).[academic.oup.com] Abstract Acute respiratory failure can be the product of any of a great number of muscular, neuromuscular, and neurologic causes.[link.springer.com]

  • Congenital Myasthenic Syndrome

    […] attack is followed by respiratory failure that lasts for weeks.8 A few patients are respirator-dependent and paralyzed since birth3 and some develop brain atrophy caused[rarediseases.org] Congenital myasthenic syndromes are classified as presynaptic, synaptic, or postsynaptic, depending on the primary defect's location within the neuromuscular junction.[ncbi.nlm.nih.gov] Acute life-threatening crises with respiratory failure are frequent in rapsyn congenital myasthenia particularly during infancy and early childhood.[pn.bmj.com]

  • Slow-Channel Congenital Myasthenic Syndrome

    Respiratory Failure and Myoglobinuria 539 Case 86 A Uremic Man with Proximal Muscle Weakness 545 Case 87 A Woman with Weakness Elevated Cholesterol and Serum Creatine Kinase[books.google.com] […] by the site of the transmission defect: presynaptic, synaptic, and postsynaptic.[link.springer.com] […] attack is followed by respiratory failure that lasts for weeks.8 A few patients are respirator-dependent and paralyzed since birth3 and some develop brain atrophy caused[rarediseases.org]

  • Congenital Myasthenic Syndrome Type 1B

    Respiratory compromise Weakness of the muscles of ventilation can cause acute respiratory failure. This is an acute neurological emergency that requires ventilation.[patient.info] […] within the neuromuscular junction Presynaptic Synaptic Postsynaptic P.J.[authorstream.com] This may lead to acute respiratory failure and patients often require a respirator to assist breathing during the crisis.[mda.org.au]

  • Congenital Myasthenic Syndrome 14

    Respiratory compromise Weakness of the muscles of ventilation can cause acute respiratory failure. This is an acute neurological emergency that requires ventilation.[patient.info] There are many types of CMS, grouped into three main categories named for the part of the neuromuscular junction that’s affected: presynaptic (the nerve cell), postsynaptic[mda.org] […] attack is followed by respiratory failure that lasts for weeks.8 A few patients are respirator-dependent and paralyzed since birth3 and some develop brain atrophy caused[rarediseases.org]

  • Congenital Slow-Channel Myasthenic Syndrome Type 4A

    Severe cases result in respiratory failure, requiring mechanical ventilation.[neupsykey.com] […] within the neuromuscular junction Presynaptic Synaptic Postsynaptic P.J.[authorstream.com] Thus, a presynaptic defect of acetylcholine resynthesis, packaging or mobilisation was proposed ( 8, 9, 16 ).[academic.oup.com]

  • Juvenile Myasthenia Gravis

    Respiratory failure is the most concerning acute presentation and these patients should be adequately oxygenated and ventilated.[jems.com] Classification of congenital myasthenic syndrome Usually classified according to the defective site of the neuromuscular junction, it is often divided into presynaptic, synaptic[intechopen.com] junction [ 1, 3 ]. 3.[intechopen.com]

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