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10,420 Possible Causes for adhesion, cell, human, molecule, neuronal, protein,, putative

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  • Herpes Simplex Virus 1 Infection

    The frequencies of marker-positive neurons and their average neuronal sizes were assessed, with TrkA-positive (61.82%) neurons being the most abundant, and Ret-positive (26.93%[ncbi.nlm.nih.gov] Sections from the cultured TG fragments were stained with antisera against non-structural proteins such as the immediate early (IE) protein ICP27 and the early (E) proteins[ncbi.nlm.nih.gov] An integration analysis of circRNAs, genes, and miRNAs was applied to investigate the putative function of the dysregulated circRNAs.[ncbi.nlm.nih.gov] Soluble intercellular adhesion molecule-1 (sICAM-1) in patients' serum also was increased to a mean level of 398 /- 130 ng/ml at the first visit.[ncbi.nlm.nih.gov] […] and TSCCa cells, (iii) slow cell death followed by necrosis in BF and OSF cells (however, these cells showed a different type of CPE), (iv) a classical slow cell death in[ncbi.nlm.nih.gov] We examined whether human neuronal cells (primary human neurons, NT2-N and CHP-212 cells) express TLRs and mount type I IFN-mediated innate immunity against herpes simplex[ncbi.nlm.nih.gov] Put a gauze pad or cotton ball over the needle site as the needle is removed. Put pressure on the site and then put on a bandage.[northshore.org]

  • Porphyromonas Gingivalis

    Further, gingipains were neurotoxic in vivo and in vitro, exerting detrimental effects on tau, a protein needed for normal neuronal function.[ncbi.nlm.nih.gov] In addition, FimC and FimD bound to fibronectin and type 1 collagen, whereas FimE failed to interact with these matrix proteins.[ncbi.nlm.nih.gov] We have independently generated a transposon insertion mutant library (Library 2) for the same P. gingivalis strain and herein compare genes that are putatively essential[ncbi.nlm.nih.gov] adhesion domain-containing proteins.[ncbi.nlm.nih.gov] Minor fimbriae (Mfa1) are essential for P. gingivalis cell-cell aggregation.[doi.org] […] gingival epithelium (HGE) cells and human periodontal ligament (HPL) cells to produce various inflammatory mediators.[ncbi.nlm.nih.gov] We developed and tested potent, selective, brain-penetrant, small-molecule gingipain inhibitors in vivo.[doi.org]

  • Coxsackie Virus

    In vitro neuron depolarization assays.[doi.org] [bsid125147] PodNet: protein-protein interactions in the podocyte PodNet: protein-protein interactions in the podocyte PodNet is a manually curated network of protein-protein[ncbi.nlm.nih.gov] Carson, SD, Chapman, NN, Tracy SM (1997) Purification of the putative coxsackievirus B receptor from HeLa cells.[doi.org] […] infection and cell adhesion.[doi.org] Homo sapiens CXADR Ig-like cell adhesion molecule (CXADR), transcript variant 3, mRNA gi 333470706 ref NM_001207064.1 Nucleotide Homo sapiens CXADR Ig-like cell adhesion molecule[ncbi.nlm.nih.gov] Mol Biol Cell. 2005;16(10):5040–52. doi: 10.1091/mbc.E05-03-0193 .[doi.org] Information about CAR expression in normal and diseased human skeletal muscle is lacking.[ncbi.nlm.nih.gov]

  • LIG4 Syndrome

    TUNEL/neuronal marker/BrdU staining. Snap-frozen samples were used.[jneurosci.org] Tandem BRCT domains of LigIV mediate a unique mode of protein-protein interaction.[mcb.asm.org] Putative hydrogen-bonding interactions are indicated by black dashed lines.[nature.com] […] insertion between amino acids G149 and H150 and behaved like the wild-type strain, whereas the neighboring insertion mutants I2 (L148-G149) and I4 (H150-A151) were deficient for adhesion[clippingpathtoindia.com] […] the non-homologous end-joining (NHEJ) DNA double-strand break repair pathway needed for V(D)J recombination and the generation of the T cell receptor and immunoglobulin molecules[jhu.pure.elsevier.com] We report here on a case of LIG4 syndrome complicated with distinct EBV-associated B-cell lymphoma.[ncbi.nlm.nih.gov] PAGES GENES INVOLVED Human Gene Zebrafish Ortholog OMIM Term OMIM Phenotype ID LIG4 lig4 LIG4 syndrome 606593 ZEBRAFISH MODELS No data available PHENOTYPE No data available[zfin.org]

  • Rhinovirus

    Expression of a Delta homologue in prospective neurons in the chick . Nature 375 , 787–790 (1995). 40. Neubüser, A. , Peters, H. , Balling, R. & Martin, G.R.[doi.org] In BEC OM-85 had no significant effect on the expression of ICOS, ICOSL and MHC-2 membrane proteins nor on the adaptor protein MyD88.[ncbi.nlm.nih.gov] The lack of such an effect on RV1A, a minor-group RV that enters the cell by a different receptor, suggests that intercellular adhesion molecule 1 (ICAM1), the receptor for[ncbi.nlm.nih.gov] Human rhinoviruses (HRVs), first discovered in the 1950s, are responsible for more than one-half of cold-like illnesses and cost billions of dollars annually in medical visits[ncbi.nlm.nih.gov] Expression of a Delta homologue in prospective neurons in the chick. Nature. 1995; 375 :787–790. [ PubMed ] 40. Neubuser A, Peters H, Balling R, Martin GR.[ncbi.nlm.nih.gov] The allergic environment also increased expression of pattern-recognition receptors and of intercellular adhesion molecule 1, the cell surface receptor for RV.[ncbi.nlm.nih.gov] Human rhinovirus (HRV)-induced wheezing illnesses during early life are a potential inciting stimulus for remodeling.[ncbi.nlm.nih.gov]

  • Rabies Virus

    […] and neurons of the central amygdala.[doi.org] The multifunctional RABV P-protein has essential roles in genome replication, and forms interactions with cellular STAT proteins that are thought to underlie viral antagonism[ncbi.nlm.nih.gov] It appeared that this intermediate is at an advanced stage of the fusion process when a putative hemifusion diaphragm is already destabilized, but lipid mixing is still restricted[jcb.rupress.org] Here, we identified another cellular partner of P, the focal adhesion kinase (FAK).[ncbi.nlm.nih.gov] […] such as neural cell adhesion molecule (NCAM).[ncbi.nlm.nih.gov] […] by lentivirus-based transduction of HEK293 cells.[ncbi.nlm.nih.gov] Human globulin immune to rabies virus has also been used for treatment of one case of clinical human rabies; this use was based on the observation that antibodies to rabies[ncbi.nlm.nih.gov]

  • Prion Disease

    We found that depleting endogenous neuronal PrPc in mice with established neuroinvasive prion infection reversed early spongiform change and prevented neuronal loss and progression[ncbi.nlm.nih.gov] The 'protein-only hypothesis' provides a theoretical model to explain how a protein self-replicates without nucleic acid, which predicts that a prion, the proteinaceous infectious[ncbi.nlm.nih.gov] In an accompanying article, Surmeier et al. put the case that the prion theory can’t explain everything about Parkinson’s.[blogs.discovermagazine.com] PrP C is a glycosylphosphatidylinositol-anchored cell-surface glycoprotein; some have speculated that it may have a role in cell adhesion or signaling processes, but its exact[emedicine.com] Our findings can deepen the understanding of prion disease and may guide the design of peptide mimetics or small molecule to mimic the protective effect of V127 variant.[ncbi.nlm.nih.gov] Mononuclear phagocytes (MNP) are a heterogeneous population of dendritic cells (DC) and macrophages.[ncbi.nlm.nih.gov] Prion diseases of humans and animals: their causes and molecular basis.[ncbi.nlm.nih.gov]

  • Neuronal Ceroid Lipofuscinosis

    Cln3-deficient neurons also displayed an abnormal organization of their neurites.[ncbi.nlm.nih.gov] To gain insight into the function of CLN8 protein, we employed the split-ubiquitin membrane-based yeast two-hybrid (MYTH) system, which detects protein-protein interactions[ncbi.nlm.nih.gov] A mutation responsible for the disease has recently been identified in a novel gene on chromosome 8p23, encoding a putative membrane protein with an unknown function.[ncbi.nlm.nih.gov] Impaired cell adhesion and apoptosis in a novel CLN9 Batten disease variant. Ann Neurol. 2004; 56 :342–350. [ PubMed ] 31.[ncbi.nlm.nih.gov] The overall goal of this proposal is to perform experiments to discover this molecule, which mediates GMN-AAV brain targeting and transduction.[grantome.com] Previous preclinical studies have demonstrated that human CNS stem cells (HuCNS-SCs) produce both PPT-1 and TPP1 and result in donor cell engraftment and reduced accumulation[ncbi.nlm.nih.gov] Other mammalian ortholog(s) used D. melanogaster Gene Information (1) Comments on ortholog(s) High-scoring ortholog of human CLN3 (1 Drosophila to 1 human).[flybase.org]

  • Inflammation

    In addition, hAMC treatment also promoted the production of neuron-repair factors (NGF, CNTF, and BDNF) in the CNS of EAE mice.[ncbi.nlm.nih.gov] The rate of protein synthesis in vivo was measured by the incorporation of [3H]phenylalanine into liver proteins in a chronic (5 day) intra-abdominal abscess model.[doi.org] Compared with normal epithelium and noninflammation-induced tumors, inflammation-induced tumors gained DNA methylation at CpG islands, some of which are associated with putative[ncbi.nlm.nih.gov] BACKGROUND: Spinal adhesive arachnoiditis (SAA) is an inflammatory process of the meninges.[ncbi.nlm.nih.gov] In addition, tumour cells have co-opted some of the signalling molecules of the innate immune system, such as selectins, chemokines and their receptors for invasion, migration[ncbi.nlm.nih.gov] Tryptases and chymases are the major proteins stored and secreted by mast cells.[ncbi.nlm.nih.gov] School of Human Kinetics and Allan McGavin Sports Medicine Centre, 3055 Wesbrook Mall, University of British Columbia, Vancouver, BC V6T 1Z3, Canada CA 3.[doi.org]

  • Acute Inflammation

    The inflammation had rather more dramatic effects on gamma-neurons. Many showed control responses to leg movements, and these were measurably modified by inflammation.[ncbi.nlm.nih.gov] Abstract The protein C system plays an active role in modulating severe systemic inflammatory processes such as sepsis, trauma, and acute respiratory distress syndrome (ARDS[ncbi.nlm.nih.gov] Thyrostimulin, a putative glycoprotein hormone, comprises the subunits GPA2 and GPB5 and activates the TSH receptor (TSHR).[ncbi.nlm.nih.gov] Unexpectedly, immobilized MK mediated PMN adhesion under static and flow conditions, whereas PMN-derived MK was dispensable for the induction of adhesion.[ncbi.nlm.nih.gov] As a consequence, the iFGF23/cFGF23 ratio, an indicator of the proteolytic cleavage of the FGF23 molecule, was 0·78 3·87 at peak infection and increased to 1·49 3·00 after[ncbi.nlm.nih.gov] […] count, cell viability, reactive oxygen species (ROS) production, apoptosis and cell cycle.[ncbi.nlm.nih.gov] Re-challenge experiments were also carried out in mice where we obtained similar results as in humans.[ncbi.nlm.nih.gov]