Adrenal Failure: Causes & Reasons

Warning: Do not use in emergencies, if pregnant, if under 18, or as a substitute for a doctor’s advice or diagnosis. Learn more

Possible Causes for Adrenal Failure

Hypochromic Microcytic Anemia with Iron Overload Type 2

Latent adrenal and thyroid failure was detected in one patient. Which treatment must I follow if I have the disease? [enerca.org]

Once case of fatal adrenal hemmorhage. [89] Joints bones muscles cartilage: Hypotonia (generalized or tructal) with increasing severity. [autoinflammatory-search.org]

Sideroblastic anaemia and primary adrenal insufficiency due to a mitochondrial respiratory chain disorder in the absence of mtDNA deletion. [emedicine.medscape.com]

Triple A Syndrome

Adrenal insufficiency usually presents in the first decade of life, however in some patients it may occur later in life or may even lack completely. [ncbi.nlm.nih.gov]

All known patients with triple A-like disorders are still young so that we cannot exclude that they develop adrenal failure at a later time. [abstracts.eurospe.org]

Acronym AAAS Synonyms ACTH-resistant adrenal insufficiency with achalasia and alacrima Addisonian-achalasia syndrome Alacrima-achalasia-addisonianism Alacrima-achalasia-adrenal [uniprot.org]

Neonatal Adrenoleukodystrophy

X-linked ALD is caused by failure in the metabolism of very long-chain fatty acids which accumulate principally in the CNS and adrenal glands. [rb.org.br]

In most cases, a severe adrenal insufficiency occurs: the adrenal glands are severely atrophied and plasma ACTH levels were markedly elevated. [ela-asso.com]

The latter, however, does not correct the adrenal insufficiency. or prevent the myelopathy. [medlink.com]

Duchenne Muscular Dystrophy

Adrenal insufficiency Adrenal insufficiency due to suppression of the hypothalamic-pituitary-adrenal (HPA) axis is a rare but life-threatening condition that can develop if [ncbi.nlm.nih.gov]

[…] of the adrenal glands and eventually death. [en.wikipedia.org]

Endocrine management The endocrine complications of DMD and its treatment include impaired growth, delayed puberty, and adrenal insufficiency. [ncbi.nlm.nih.gov]

Adrenal Insufficiency

Bilateral adrenalectomy or drug-induced adrenal insufficiency may be considered as iatrogenic etiologies for adrenal failure. [bmcendocrdisord.biomedcentral.com]

Causes of adrenal failure The number of patients that are permanently adrenal insufficient due to treatment of Cushing’s syndrome is actually quite small compared to other [csrf.net]

This report highlights the value of genetic testing for definite diagnosis in children with primary adrenal failure due to abnormal adrenal gland development, providing the [ncbi.nlm.nih.gov]

Addison Disease

adrenal failure crisis acute insufficiency addison cortisol therapy treatment This is a preview of subscription content, log in to check access. [doi.org]

[…] other causes of adrenal failure using other tests as necessary. [ncbi.nlm.nih.gov]

[…] of death for patients with both DM and primary adrenal failure. [doi.org]

Congenital Isolated ACTH Deficiency

1 diabetes mellitus, autoimmune thyroid disease, and adrenal failure. [emedicine.medscape.com]

[…] mellitus, adrenal insufficiency). [clinicaladvisor.com]

Normal cortisol responseto corticotropinin patients with secondary adrenal failure. Arch Intern Med 2083;143:2276–2279. Google Scholar 29. [doi.org]

Adrenal Infarction

Infections of the adrenal gland such as tuberculosis and histoplasmosis may cause adrenal failure. [unboundmedicine.com]

[…] acute adrenal failure, revealing bilateral adrenal infarction, as a first manifestation of the PAPS. [ard.bmj.com]

Case Report First Online: 22 March 2014 Abstract A 72-year-old man developed bilateral adrenal hemorrhage causing primary adrenal failure three days after total hip replacement [link.springer.com]

Addisonian Crisis

The diagnosis of acute hypoadrenalism seldom is considered in patients without known adrenal insufficiency who are taking supraphysiologic amounts of glucocorticoids. [ncbi.nlm.nih.gov]

However, failure to treat a pregnant woman with adrenal insufficiency can result in death of mother and/or loss of the child. [endocrinology.org]

Adrenal crisis is a life threatening emergency in patients with primary (classic addisonian crisis), or secondary adrenal failure. [aci.health.nsw.gov.au]

Adrenal Hemorrhage

insufficiency. [endocrine-abstracts.org]

[…] haemorrhage is a rare cause of adrenal failure. [casesjournal.biomedcentral.com]

Ebola virus infection may also cause similar acute adrenal failure. [ citation needed ] Diagnosis [ edit ] Diagnostic criteria is based on clinical features of adrenal insufficiency [en.wikipedia.org]

Hypopituitarism

Cortisol >20 µg/dL – normal; adrenal insufficiency unlikely Cortisol ≤20 µg/dL but ≥5 µg/dL – evaluate for pituitary failure; secondary adrenal insufficiency likely Evaluation [arupconsult.com]

[…] µg/dL but ≥5 µg/dL – evaluate for pituitary failure; secondary adrenal insufficiency likely Evaluation for pituitary failure Insulin tolerance testing (ITT) Not recommended [arupconsult.com]

CI: epilepsy, heart disease, adrenal failure. Consult lab first. [almostadoctor.co.uk]

Iatrogenic Cushing Syndrome

In the literature, there are a few adult cases who developed ICS and subsequent adrenal insufficiency associated with TS. [ncbi.nlm.nih.gov]

Following prolonged use of CP at medium doses, adrenal insufficiency may be more common than previously described. [ncbi.nlm.nih.gov]

Sibel et al. [ 6 ] reported that four patients had evidence of secondary adrenal failure following withdrawal of CP or considerable lowering of the dose, and the HPA axis [ncbi.nlm.nih.gov]

Sheehan Syndrome

Acute adrenal failure (addisonian crisis) can lead to life-threatening shock. [mayoclinic.org]

Most symptoms of secondary adrenal insufficiency are similar to those of primary adrenal insufficiency. [mayoclinic.org]

Primary adrenal insufficiency When the cortex is damaged and doesn't produce enough adrenocortical hormones, the condition is called primary adrenal insufficiency. [mayoclinic.org]

Bilateral Massive Adrenal Hemorrhage

Abdominal or flank tenderness on examination of a patient with isolated severe TBI and shock should raise the suspicion of adrenal failure. [jintensivecare.biomedcentral.com]

With any adrenal mass, adrenal insufficiency is rare unless both glands are involved. [merckmanuals.com]

Pituitary Apoplexy

adrenal failure crisis acute insufficiency addison cortisol therapy treatment This is a preview of subscription content, log in to check access. [doi.org]

Dehydroepiandrosterone replacement in women with adrenal insufficiency. N Engl J Med 1999;341(14): 1013–1020. [doi.org]

Adrenal insufficiency. N Engl J Med 1996;335(16): 1206–1212. Google Scholar 5. van Geel BM, Assies J, Wanders RJ, Barth PG. [doi.org]

Autoimmune Polyendocrine Syndrome Type 2

Search terms included hyponatremia, hypothyroidism, autoimmune thyroid disease, adrenal insufficiency, adrenal failure, Schmidt’s syndrome and autoimmune polyendocrine syndrome [link.springer.com]

Adrenal insufficiency may be primary, secondary, or tertiary with varied etiologies. [unboundmedicine.com]

Search terms included hyponatremia, hypothyroidism, autoimmune thyroid disease, adrenal insufficiency, adrenal failure, Schmidt's syndrome and autoimmune polyendocrine syndrome [insights.ovid.com]

Hypoaldosteronism

One month later she was admitted with signs of acute adrenal failure, i.e. fatigue, severe nausea, blood pressure of 80/60 mmHg, extracellular dehydration, hyponatremia (118 [ncbi.nlm.nih.gov]

CONCLUSIONS: Adrenal dysfunction was common in critically ill cirrhotic patients. [ncbi.nlm.nih.gov]

There are several causes for this condition, including adrenal insufficiency, congenital adrenal hyperplasia, and some medications such as certain diuretics, NSAIDs, and ACE [en.wikipedia.org]

Diffuse Cerebral Sclerosis of Schilder

Adrenal insufficiency (AI), either subclinical or overt, is found in the majority of patients with ALD, and may be present in up to 92% of children with cerebral disease. [doi.org]

X-linked ALD is caused by failure in the metabolism of very long-chain fatty acids which accumulate principally in the CNS and adrenal glands. [ncbi.nlm.nih.gov]

[…] gland failure (Addison type) symptoms include: Coma Decreased appetite Increased skin color Loss of weight and muscle mass (wasting) Muscle weakness Vomiting Tests for this [nlm.nih.gov]

Waterhouse-Friderichsen Syndrome

Waterhouse-Friderichsen syndrome, also known as hemorrhagic adrenalitis, is a condition that describes acute adrenal failure, caused by hemorrhage within the adrenal glands [symptoma.com]

In general, CMV is thought to cause adrenalitis, but rarely leads to manifestations of adrenal insufficiency during the clinical course. [doi.org]

There is bleeding into the ADRENAL GLANDS causing adrenal failure and SHOCK. Enlarging purple spots appear on the skin and there is rapid collapse and coma. [medical-dictionary.thefreedictionary.com]

Autoimmune Polyendocrine Syndrome

Patients with the classic triad (hypoparathyroidism, adrenal failure, and candidiasis) made up only half the series. [nejm.org]

Abstract Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy is a rare autosomal recessive disorder characterized by hypoparathyroidism, adrenal failure, chronic [ncbi.nlm.nih.gov]

This was associated with adrenal failure, which was the first or only endocrinopathy in 47% of males vs. 7% of females. [ncbi.nlm.nih.gov]

Autoimmune Hypophysitis

CI: epilepsy, heart disease, adrenal failure. Consult lab first. [almostadoctor.co.uk]

Khan, Normal Short Synacthen Test in Patients with Secondary Adrenal Failure, Annals of Saudi Medicine, 10.5144/0256-4947.1998.151, 18, 2, (151-153), (1998). [doi.org]

Secondary hypothyroidism and adrenal failure occur only in the more advanced cases. [web.archive.org]

Myxedema Coma

If hypothyroidism is due to hypothalamic or pituitary insufficiency, the condition is even more serious because it is also accompanied by adrenal failure. [aneskey.com]

[…] hypopituitarism and secondary adrenal insufficiency. [emedicine.medscape.com]

Hydrocortisone should be administered until coexisting adrenal insufficiency is ruled out. [ncbi.nlm.nih.gov]

Adrenal Gland Disease

Acute adrenal failure (addisonian crisis) can lead to life-threatening shock. [mayoclinic.org]

Although adrenal insufficiency usually develops over time, it can also appear suddenly as an acute adrenal failure (adrenal crisis). [hopkinsmedicine.org]

failure of the pituitary gland to adequately stimulate the production of adrenal hormones (“secondary” adrenal insufficiency). [empoweryourhealth.org]

Isolated Congenital Alacrima

Both type I and type II can be associated with vitiligo and primary gonadal failure. Acute adrenal insufficiency can complicate septic shock. [oncohemakey.com]

[…] mellitus, adrenal insufficiency). [clinicaladvisor.com]

Adrenal Cortical Insufficiency Adrenal insufficiency may result from primary adrenal failure or secondary disease to impairment of the hypothalamic-pituitary-adrenal axis [jcrpe.org]

Hypertrophy of the Adrenal Cortex

Adrenal failure can be from autoimmunity ; adrenal overactivity from tumors. Alternative practitioners often allege “ adrenal fatigue ” from chronic stress. [healthtap.com]

[…] gland can help exclude bilateral adrenal hemorrhage in patients with signs of acute adrenal failure without ambiguous genitalia or other clues to adrenal hyperplasia [4] [emedicine.medscape.com]

Last modified | 2019-04-01 « Lorenzo Odone Adrenal insufficiency » [x-ald.nl]

Drug-Induced Pituitary Deficiency

ACTH deficiency does not result in the hyperpigmentation characteristic of primary adrenal failure. [merckmanuals.com]

insufficiency. [amboss.com]

Value of basal plasma cortisol assays in the assessment of pituitary-adrenal insufficiency. Clin Endocrinol (Oxf) 1987 ; 26: 221 –6. 16. [nejm.org]

Tuberculosis of the Adrenal Glands

Primary adrenal insufficiency is a rare disorder. [isim.org.il]

A 45 years old man was admitted to our department for investigation of a primary adrenal failure. [biopublisher.ca]

in this type of adrenal failure (called secondary adrenal insufficiency), there is no pigmentation of the skin. [yourhormones.info]

Panhypopituitarism

Acute presentation: 46 year old patient was admitted as an emergency with vomiting, hypotension and serum cortisol of 26 nmol/L indicative of adrenal failure. [endocrine-abstracts.org]

Patients with panhypopituitarism usually have features of adrenal insufficiency, hypothyroidism, and gonadal failure, along with poor responses to stress. [britannica.com]

ACTH deficiency does not result in the hyperpigmentation characteristic of primary adrenal failure. [msdmanuals.com]

Adrenal Insufficiency Secondary to Hypopituitarism

In the context of his gonadal failure and adrenal insufficiency, plasma ACTH and gonadotropins were measured and found to be inappropriately within the normal range (ACTH [casereports.bmj.com]

in this type of adrenal failure (called secondary adrenal insufficiency), there is no pigmentation of the skin. [yourhormones.info]

insufficiency occurs in both primary and secondary adrenal failure. [rch.org.au]

Hyponatremia

Thus patients with lung (pneumonia, etc.), cardiac (cardiac failure), kidney (renal insufficiency), hepatic (cirrhosis), endocrine (hypothyroidism, adrenal insufficiency) [academic.oup.com]

For its diagnosis, the following conditions must be excluded: hypotension, renal failure, adrenal insufficiency, severe hypothyroidism, as well as non-osmotic physiologic [revistanefrologia.com]

Plasma cortisol and corticotropin levels allowed the diagnosis of primary adrenal insufficiency. [ncbi.nlm.nih.gov]