Adrenal Failure: Causes & Reasons

Possible Causes for Adrenal Failure

adrenal failure crisis acute insufficiency addison cortisol therapy treatment This is a preview of subscription content, log in to check access. [doi.org]

In summary, this patient developed secondary adrenal failure in the setting of previous Addison's disease. [ncbi.nlm.nih.gov]

[…] other causes of adrenal failure using other tests as necessary. [ncbi.nlm.nih.gov]

Congenital Isolated ACTH Deficiency

[…] mellitus, adrenal insufficiency). [clinicaladvisor.com]

Once hypoadrenalism is confirmed, there may be diagnostic problems related to the underlying cause of the adrenal failure. [netdoctor.co.uk]

1 diabetes mellitus, autoimmune thyroid disease, and adrenal failure. [emedicine.medscape.com]

Triple A Syndrome

Adrenal insufficiency usually presents in the first decade of life, however in some patients it may occur later in life or may even lack completely. [ncbi.nlm.nih.gov]

All known patients with triple A-like disorders are still young so that we cannot exclude that they develop adrenal failure at a later time. [abstracts.eurospe.org]

Triple A syndrome is a rare autosomal recessive disease characterized by adrenal failure, alacrima, achalasia, and progressive neurologic symptoms. [ncbi.nlm.nih.gov]

Hypochromic Microcytic Anemia with Iron Overload Type 2

Latent adrenal and thyroid failure was detected in one patient. Which treatment must I follow if I have the disease? [enerca.org]

Once case of fatal adrenal hemmorhage. [89] Joints bones muscles cartilage: Hypotonia (generalized or tructal) with increasing severity. [autoinflammatory-search.org]

Sideroblastic anaemia and primary adrenal insufficiency due to a mitochondrial respiratory chain disorder in the absence of mtDNA deletion. [emedicine.medscape.com]

Adrenocortical Insufficiency

The causes underlying such insufficiency require a distinction between primary adrenal insufficiency or Addison's disease, involving an intrinsic alteration of the adrenal [ncbi.nlm.nih.gov]

Bilateral adrenalectomy or drug-induced adrenal insufficiency may be considered as iatrogenic etiologies for adrenal failure. [bmcendocrdisord.biomedcentral.com]

The recent description of a 46,XY patient bearing a mutation in the NR5A1 gene, causing male pseudohermaphroditism and adrenal failure, demonstrated the crucial role of SF [ncbi.nlm.nih.gov]

Hypopituitarism

Cortisol >20 µg/dL – normal; adrenal insufficiency unlikely Cortisol ≤20 µg/dL but ≥5 µg/dL – evaluate for pituitary failure; secondary adrenal insufficiency likely Evaluation [arupconsult.com]

While she was being prepared for thyroidectomy, adrenal failure developed. [ncbi.nlm.nih.gov]

[…] µg/dL but ≥5 µg/dL – evaluate for pituitary failure; secondary adrenal insufficiency likely Evaluation for pituitary failure Insulin tolerance testing (ITT) Not recommended [arupconsult.com]

Iatrogenic Adrenal Insufficiency

Dehydroepiandrosterone replacement in women with adrenal insufficiency. N Engl J Med 341: 1013, 1999. [link.springer.com]

Adrenal insufficiency. Lancet 361: 1881, 2003. Article CAS PubMed Google Scholar Barrett-Connor E, Khaw KT, Yen SSC. [link.springer.com]

Recent advances in the diagnosis and therapy of primary adrenal insufficiency. Curr Med Chem Immunol Endocr Metab Agents 2: 251, 2002. [link.springer.com]

Neonatal Adrenoleukodystrophy

X-linked ALD is caused by failure in the metabolism of very long-chain fatty acids which accumulate principally in the CNS and adrenal glands. [rb.org.br]

insufficiency Renal calcium oxalate stones Blindness Deafness Osteoporosis Fractures Expected clinical course Expected clinical course Prognosis is poor with most patients [repository.innermed.eu]

In most cases, a severe adrenal insufficiency occurs: the adrenal glands are severely atrophied and plasma ACTH levels were markedly elevated. [ela-asso.com]

Congenital Adrenal Hyperplasia

In adults, the treatment of CAH-C must include 2 primary objectives: adequate the replacement of adrenal failure and control of hyperandrogenism, through the use of corticosteroids [pesquisa.bvsalud.org]

[…] gland can help exclude bilateral adrenal hemorrhage in patients with signs of acute adrenal failure without ambiguous genitalia or other clues to adrenal hyperplasia [4] [emedicine.medscape.com]

Complications of CAH include severe hypoglycemia, adrenal insufficiency, and/or a failure to thrive. [amboss.com]

Hemochromatosis

In this article, the authors report a case of primary adrenal failure followed by primary hypoparathyroidism in a young male patient, describing diagnostic and treatment strategies [pesquisa.bvsalud.org]

[…] and/or dysrhythmias Hypothyroidism Adrenal insufficiency Testicular atrophy Parkinsonism Osteoporosis Hearing loss Pleural effusion Hair loss III. [faculty.washington.edu]

[…] gland Heart failure (iron overload can damage the heart muscle, leading to heart failure) Changes in skin color (for example, yellowish skin, tan skin not caused by the sun [daviddarling.info]

Hashimoto Thyroiditis

Simultaneous laboratory evaluation revealed primary adrenal failure and probable pernicious anaemia, thus producing a diagnosis of Schmidt's syndrome. [ncbi.nlm.nih.gov]

Acute overdose may cause fever, hypoglycemia, heart failure, coma, and unrecognized adrenal insufficiency. [en.wikipedia.org]

In particular, therapy of rhGH, used for short stature treatment, may be a trigger factor of adrenal insufficiency. [ncbi.nlm.nih.gov]

Hypoparathyroidism

Features include hypoparathyroidism, adrenal insufficiency, chronic mucocutaneous candidiasis. [patient.info]

(e.g. vitiligo or adrenal insufficiency) Are there any features to suggest immunodeficiency? [cancertherapyadvisor.com]

Adrenal failure. Vitiligo. Dental enamel hypoplasia. Genetic syndromes: Sensorineural deafness. Renal dysplasia. General learning disability. [patient.info]

Pituitary Cushing Syndrome

Iatrogenic Cushing's syndrome with osteoporosis and secondary adrenal failure in human immunodeficiency virus-infected patients receiving inhaled corticosteroids and ritonavir-boosted [emedicine.medscape.com]

[…] axis, there are immediate failures and late recurrences that will ultimately require alternate therapeutic approaches. [ncbi.nlm.nih.gov]

One patient (1.9%) was found to have an ectopic source of ACTH, and one (1.9%) had immunohistochemically confirmed adrenal tumors. [ncbi.nlm.nih.gov]

POEMS Syndrome

failure), monoclonal gammopathy (usually of IgA-lambda), skin changes, and sclerotic bone changes.1 Although not represented in the acronym, the syndrome may include other [pmj.bmj.com]

The diagnoses included hypothyroidism, chronic adrenal insufficiency (Addison’s disease), type 2 diabetes mellitus, cerebral infarction, heart failure, and depression, among [bmcendocrdisord.biomedcentral.com]

Thyroid dysfunction, hyperprolactinemia and adrenal insufficiency have also been reported. [omcr.oxfordjournals.org]

Malignant Neoplasm of the Lung

insufficiency (Addison disease): from bilateral metastases 7 hyperparathyroidism: NSCLC can produce parathyroid hormone (extremely rare) 8 hypocalcaemia: occurs in the setting [radiopaedia.org]

[…] endocrine/metabolic SIADH causing hyponatraemia: small-cell subtype ACTH secretion ( Cushing syndrome ): carcinoid and small-cell subtypes carcinoid syndrome gynaecomastia adrenal [radiopaedia.org]

Duchenne Muscular Dystrophy

[…] of the adrenal glands and eventually death. [en.wikipedia.org]

Adrenal insufficiency Adrenal insufficiency due to suppression of the hypothalamic-pituitary-adrenal (HPA) axis is a rare but life-threatening condition that can develop if [ncbi.nlm.nih.gov]

[…] the genes on chromosome X may cause disease, but below are some notable ones, with short description of symptoms: Adrenoleukodystrophy; leads to progressive brain damage, failure [en.wikipedia.org]

Sarcoidosis

[…] of patients with secondary adrenal failure due to hypothalamic-pituitary infiltration by sarcoid granulomas. 41 When there is sarcoid involvement, the adrenal gland is replaced [dx.doi.org]

insufficiency, unless a more potent mineralocorticoid is administered concomitantly. [en.wikipedia.org]

[…] by dense fibrosis, leading to adrenal insufficiency, but patients respond well to glucocorticoid and mineralocorticoid replacement. [dx.doi.org]

Adrenal Insufficiency

This report highlights the value of genetic testing for definite diagnosis in children with primary adrenal failure due to abnormal adrenal gland development, providing the [ncbi.nlm.nih.gov]

Bilateral adrenalectomy or drug-induced adrenal insufficiency may be considered as iatrogenic etiologies for adrenal failure. [bmcendocrdisord.biomedcentral.com]

Causes of adrenal failure The number of patients that are permanently adrenal insufficient due to treatment of Cushing’s syndrome is actually quite small compared to other [csrf.net]

Primary Adrenal Insufficiency

Neary N, Nieman L (2010) Adrenal insufficiency: etiology, diagnosis, and treatment. [link.springer.com]

Adrenocortical Insufficiency, Primary Adrenocortical Primary Adrenal Insufficiency Primary Adrenocortical Insufficiencies Primary Adrenocortical Insufficiency Primary Hypoadrenalism [finto.fi]

J Clin Endocrinol Metab 88:4193–4198 Article CAS PubMed Google Scholar Arlt W, Allolio B (2003) Adrenal insufficiency. [link.springer.com]

Amyloidosis

Heart complications, which affect more than a third of AL patients, include heart failure and irregular heart beat. [en.wikipedia.org]

insufficiency Liver and spleen: hepatomegaly, splenomegaly Gastrointestinal tract: malabsorption Amyloidosis should always be considered in a patient with a long-standing [amboss.com]

Hepatosplenomegaly and adrenal insufficiency are common in the advanced stage of AA amyloidosis. [intechopen.com]

Adrenal Infarction

Infections of the adrenal gland such as tuberculosis and histoplasmosis may cause adrenal failure. [unboundmedicine.com]

[…] acute adrenal failure, revealing bilateral adrenal infarction, as a first manifestation of the PAPS. [ard.bmj.com]

Case Report First Online: 22 March 2014 Abstract A 72-year-old man developed bilateral adrenal hemorrhage causing primary adrenal failure three days after total hip replacement [link.springer.com]

Addisonian Crisis

The diagnosis of acute hypoadrenalism seldom is considered in patients without known adrenal insufficiency who are taking supraphysiologic amounts of glucocorticoids. [ncbi.nlm.nih.gov]

However, failure to treat a pregnant woman with adrenal insufficiency can result in death of mother and/or loss of the child. [endocrinology.org]

The authors report a patient with a primary lymphoma of the adrenal glands presenting as acute adrenal failure. [ncbi.nlm.nih.gov]

Iatrogenic Cushing Syndrome

Primary adrenal failure is commonly associated with low cortisol and high ACTH concentrations. In our case, ACTH levels were low. [edm.bioscientifica.com]

In the literature, there are a few adult cases who developed ICS and subsequent adrenal insufficiency associated with TS. [ncbi.nlm.nih.gov]

A further specific example of this is the tertiary adrenal failure that occurs in patients recovering from surgical treatment of Cushing’s syndrome – either selective removal [endocrine-abstracts.org]

Histoplasmosis

Acute progressive disseminated histoplasmosis patients may develop CNS problems that result in encephalopathy or seizures, adrenal insufficiency, cardiac problems such as [emedicinehealth.com]

insufficiency is uncommon, though it has been a recognized manifestation of DH.(13) Failure to diagnose adrenal insufficiency could lead to a fatal outcome despite appropriate [hivinsite.ucsf.edu]

Disseminated histoplasmosis with asymptomatic adrenal involvement has been described in immunocompromised patients; whereas isolated adrenal involvement with adrenal insufficiency [ncbi.nlm.nih.gov]

Bilateral Massive Adrenal Hemorrhage

Ebola virus infection may also cause similar acute adrenal failure. [ citation needed ] Diagnosis [ edit ] Diagnostic criteria is based on clinical features of adrenal insufficiency [en.wikipedia.org]

With any adrenal mass, adrenal insufficiency is rare unless both glands are involved. [merckmanuals.com]

Hydrocortisone can sometimes reverse the adrenal insufficiency. [en.wikipedia.org]

Waterhouse-Friderichsen Syndrome

failure due to massive adrenal hemorrhage. [picmonic.com]

Ebola virus infection may also cause similar acute adrenal failure.[8] Diagnosis[edit] Diagnostic criteria are based on clinical features of adrenal insufficiency as well [en.wikipedia.org]

Patients typically show hypoglycemia, hyponatremia and hyperkalemia, along with adrenal failure in the ACTH stimulation test. [picmonic.com]

Autoimmune Polyendocrine Syndrome Type 2

Investigations confirmed both primary hypothyroidism and primary adrenal failure (Schmidt syndrome). [ncbi.nlm.nih.gov]

Search terms included hyponatremia, hypothyroidism, autoimmune thyroid disease, adrenal insufficiency, adrenal failure, Schmidt’s syndrome and autoimmune polyendocrine syndrome [link.springer.com]

Search terms included hyponatremia, hypothyroidism, autoimmune thyroid disease, adrenal insufficiency, adrenal failure, Schmidt's syndrome and autoimmune polyendocrine syndrome [insights.ovid.com]

Adrenal Hemorrhage

insufficiency. [endocrine-abstracts.org]

[…] haemorrhage is a rare cause of adrenal failure. [casesjournal.biomedcentral.com]

Tuberculosis of the Adrenal Glands

Primary adrenal insufficiency is a rare disorder. [isim.org.il]

You may hear doctors refer to this as "adrenal failure." [zocdoc.com]

in this type of adrenal failure (called secondary adrenal insufficiency), there is no pigmentation of the skin. [yourhormones.info]

Adrenal Gland Disease

Acute adrenal failure (addisonian crisis) can lead to life-threatening shock. [mayoclinic.org]

failure of the pituitary gland to adequately stimulate the production of adrenal hormones (“secondary” adrenal insufficiency). [empoweryourhealth.org]

Most symptoms of secondary adrenal insufficiency are similar to those of primary adrenal insufficiency. [mayoclinic.org]