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90 Possible Causes for Adult Onset - 40s, Frontal Bossing

  • Acromegaly

    The forehead and overlying skin is thickened, sometimes leading to frontal bossing.[orpha.net] Untreated acromegaly results in marked bony and soft tissue changes including an altered facial appearance (frontal bossing, prognathism), enlargement of the hands and feet[acromegaly.org] It is most often diagnosed in middle-aged adults (average age 40 years). Men and women are equally affected.[patient.info]

  • Gigantism

    Other symptoms may include delayed puberty ; double vision or difficulty with side (peripheral) vision; prominent forehead ( frontal bossing ) and a prominent jaw; headache[rarediseases.info.nih.gov] It is most often diagnosed in middle-aged adults (average age 40 years, men and women equally affected).[doi.org] Other symptoms include: Delayed puberty Double vision or difficulty with side (peripheral) vision Very prominent forehead ( frontal bossing ) and a prominent jaw Gaps between[medlineplus.gov]

  • Ondine Syndrome

    Specifically, the case with a translocation comparable to a 4p12-13 deletion and Hirschsprung disease was described as having microcephaly, frontal bossing, prominent forehead[dx.doi.org] onset primary alveolar hypoventilation syndrome.[kegg.jp] Pediatr Pulmonol 38 : 349–351 39 Weese-Mayer DE, Berry-Kravis EM, Zhou L 2005 Adult identified with congenital central hypoventilation syndrome-mutation in PHOX2B and late-onset[doi.org]

  • Basal Cell Carcinoma

    Zhang et al reported an inverse association between body mass index (BMI) and onset of BCC before age 40 years.[emedicine.com] Here, we report on an 18-month-old boy presenting with medulloblastoma, frontal bossing, and multiple skeletal anomalies and his father who has basal cell carcinomas, palmar[ncbi.nlm.nih.gov] Medulloblastoma (usually desmoplastic) Minor Criteria Occipital-frontal circumference 97th percentile and frontal bossing Macrocephaly (adjusted for height) Macrocephaly ([cancer.gov]

  • Laron Syndrome

    She presented frontal bossing and depressed nasal bridge. IGF-1 generation test showed no response, suggesting a GH resistance evidence.[ncbi.nlm.nih.gov] , 127, 265 ) Delayed onset and reduced severity of neoplastic disease ( 133, 134, 312 ) Delayed maturation; reduced adult body size ( 20, 147, 334 ) Improved maintenance of[doi.org] The frontal fontanel was open (1.5 cm 1.5 cm), and pale skin, frontal bossing, blue sclera, a hypoplastic nasal bridge, obesity, and an increased upper-to-lower segment ratio[ncbi.nlm.nih.gov]

  • Alexander Disease

    Megalencephaly and frontal bossing are further manifestations of the disease.[orpha.net] Alexander disease: A family study. ( 29620072 ) Lichtenstein M.L....Feldman H.H. 2017 40 Ataxia and autonomic dysfunction as presenting symptoms in late-onset Alexander disease[malacards.org] bossing, and seizures.[ncbi.nlm.nih.gov]

  • Growth Hormone Deficiency

    At 1.8 years of age the patient presented severe growth retardation (height 61.2 cm, -7.4 SDS), truncal obesity, frontal bossing, doll face, and acromicria.[ncbi.nlm.nih.gov] To this end we studied 20 patients (11 men and 9 women, aged 19-40 yr), 10 with childhood-onset (co-) and 10 with adult-onset (ao-) disease, and 20 sex- and age-matched healthy[ncbi.nlm.nih.gov]

  • Mohr Syndrome

    The extra-oral examination revealed frontal bossing, down-sloping forehead, broad nasal base, uneven nostrils, wide set eyes, low-set ears, flat midface, dry skin and coarse[jofs.in] The slowly progressive decline in visual acuity leads to legal blindness around age 30 to 40 years ( 3 ) . The onset of dementia is usually around 40 years old ( 4 ) .[scielo.br] The slowly progressive decline in visual acuity leads to legal blindness around age 30 to 40 years (3) . The onset of dementia is usually around 40 years old (4) .[sboportal.org.br]

  • High Myopia-Sensorineural Deafness Syndrome

    Saudi Arabia Gripp et al. (1997) described a male infant, the offspring of first-cousin parents from Saudi Arabia, who had wide anterior fontanel and metopic suture with frontal[cags.org.ae] The onset of NMO varies from childhood to adulthood, with two peaks, one in childhood and the other in adults in their 40s.[afb.org] bossing, hypertelorism, downslanting palpebral fissures, bilateral iris coloboma, omphalocele, and bilateral absence of the diaphragm with herniation of internal organs causing[cags.org.ae]

  • Pseudohypoparathyroidism

    Adult onset pseudohypoparathyroidism type-1b with normal phosphaturic response to exogenous parathyroid hormone.[ijem.in] He and his mother were obese and had round faces, frontal bossing, small noses, flat nasal bridges, brachydactyly. His mother showed no hormonal resistance.[ncbi.nlm.nih.gov] Indian J Endocr Metab [serial online] 2011 [cited 2019 May 13];15:337-40.[ijem.in]

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