Advanced Bone Age: Causes & Reasons

Possible Causes for Advanced Bone Age

Of these 18 children, 3 (17%) had an advanced bone age and were diagnosed with Sotos syndrome. [ncbi.nlm.nih.gov]

Facial gestalt and macrocephaly, rather than advanced bone age, are the strongest indications for clinical diagnosis. [ncbi.nlm.nih.gov]

Sotos syndrome, or cerebral gigantism, is a rare genetic condition characterized by tall stature, gigantism, dolichocephaly, advanced bone age and learning disability. [ncbi.nlm.nih.gov]

Congenital Generalized Lipodystrophy Type 1

The 3 patients exhibited rapid growth with advanced bone age, dilation of the cerebral ventricles, hepatosplenomegaly with cirrhosis, generalized muscular overdevelopment, [emedicine.medscape.com]

bone age Early bone maturation [ more ] 0005616 Acute pancreatitis Acute pancreatic inflammation 0001735 Autosomal recessive inheritance 0000007 Cirrhosis Scar tissue replaces [rarediseases.info.nih.gov]

[…] muscle 0001638 Percent of people who have these symptoms is not available through HPO Acanthosis nigricans Darkened and thickened skin 0000956 Accelerated skeletal maturation Advanced [rarediseases.info.nih.gov]

Marshall-Smith Syndrome

From Wikidata Jump to navigation Jump to search syndrome that is characterized by advanced bone age, failure to thrive, respiratory problems, dysmorphic facial features, and [wikidata.org]

KEYWORDS: Advanced bone age; Aortic root dilatation; Marshall-Smith syndrome; Novel pathogenic variant; Precocious puberty [ncbi.nlm.nih.gov]

Marshall-Smith syndrome is characterized by advanced bone age, failure to thrive, respiratory problems, dysmorphic facial features, and variable mental retardation. [ncbi.nlm.nih.gov]

Weaver Syndrome

Accelerated growth and advanced bone age are consistent findings in Weaver-Smith syndrome (WSS). [ncbi.nlm.nih.gov]

In addition to the characteristic manifestations of overgrowth and advanced bone age, the facies were typical, with a broad forehead, hypertelorism, a long philtrum, micrognathia [ncbi.nlm.nih.gov]

Weaver syndrome is a rare disorder of unknown etiology characterized by skeletal overgrowth, distinctive craniofacial and digital abnormalities, and advanced bone age. [ncbi.nlm.nih.gov]

Congenital Generalized Lipodystrophy

It is characterized by a lack of adipose tissue throughout the body from birth, muscular hypertrophy, advanced bone age, fatty liver, and insulin resistance. [ncbi.nlm.nih.gov]

The clinical phenotype, viz. lack of subcutaneous fat, hepatosplenomegaly, cardiomegaly, and advanced bone age was also documented. [ncbi.nlm.nih.gov]

One patient exhibited multiple signs of overgrowth such as advanced bone age and macropenis. [ncbi.nlm.nih.gov]

Alstrom Syndrome

The advanced bone age and normal early growth may be due to hyperinsulinism. [ncbi.nlm.nih.gov]

One additional manifestation not described widely in the literature, advanced bone age, was observed in all subjects tested. [ncbi.nlm.nih.gov]

Alström Syndrome Further features identified: Congestive heart failure secondary to cardiomyopathy Sensorineural hearing loss Short stature / advanced bone age / scolosis [slideshare.net]

Congenital Generalized Lipodystrophy Type 2

Symptoms Patients have accelerated growth, voracious appetite, and advanced bone age during early childhood. [checkorphan.org]

Additional exams show advanced bone age, evidence of liver dysfunction (increase in aminotransferases), dyslipidemia (increase in triglycerides, decrease in HDL, with possible [scielo.br]

Metaphyseal Acroscyphodysplasia

Advanced bone age Early bone maturation [ more ] 0005616 Brachydactyly Short fingers or toes 0001156 Cone-shaped metacarpal epiphyses Cone-shaped end part of long bone 0006059 [rarediseases.info.nih.gov]

advanced bone age and complete alopecia (5). [ispub.com]

Showing of 40 | 80%-99% of people have these symptoms Abnormality of the metaphysis Abnormality of the wide portion of a long bone 0000944 Accelerated skeletal maturation [rarediseases.info.nih.gov]

McCune-Albright Syndrome

Skeletal survey showed dysplastic changes involving multiple bones and advanced bone age. Reports of MAS in a boy with unilateral macroorchidism are scarce. [ncbi.nlm.nih.gov]

However, there was increase in uterine volume, advancement of bone age, and two episodes of vaginal bleeding (18th and 24th months). [ncbi.nlm.nih.gov]

Imaging studies: Ultrasonography (ovarian cysts, nodular adrenal hyperplasia); skeletal radiography (widespread cystic bony lesions, advanced bone age, fractures and deformities [accessanesthesiology.mhmedical.com]

Central Precocious Puberty Type 2

[…] before any lab draw, especially if bone age advanced. [hippoed.com]

Precocious puberty associated with hypothalamic hamartomas usually presents before 4 years of age and is associated with accelerated linear growth for age, advanced bone age [hopeforhh.org]

Bone age was advanced in all cases. [academic.oup.com]

Acrodysostosis Type 1

Individuals often have advanced bone age, may be obese and some are resistant to multiple hormones including parathyroid, calcitonin and growth hormone releasing hormone. [exeterlaboratory.com]

ACRDYS1 is caused by heterozygous mutation in the PRKAR1A gene and is characterized by short stature, severe brachydactyly, facial dysostosis, nasal hypoplasia, advanced bone [iofbonehealth.org]

Abnormal vertebral size / shape - Advanced bone age - Broad nose / nasal bridge - Cone epiphyses / epiphysis - Depressed nasal bridge - Flattened nose - Hypoplastic maxillary [csbg.cnb.csic.es]

Lipodystrophy

Advanced bone age and linear growth and skeletal muscle prominence can be seen during childhood. [dnatesting.uchicago.edu]

bone age, acanthosis nigricans and hirsutism. lip·o·dys·tro·phy ( lip'ō-dis'trō-fē ), 1. [medical-dictionary.thefreedictionary.com]

Patients with CGL can develop hyperphagia as a result of profound leptin deficiency in early childhood, and may have accelerated linear growth, advanced bone age and features [ncbi.nlm.nih.gov]

Adrenogenital Syndrome

Advanced bone age may be diagnosed employing plain radiography. In patients with ambiguous genitalia, karyotyping should be carried out. [symptoma.com]

Gigantism

Her precocious manifestations were public hair, acne vulgaris, hirsutism, and advanced bone age. [ncbi.nlm.nih.gov]

[…] height, weight and bone age [ 1 ]. [ncbi.nlm.nih.gov]

bone age. [ncbi.nlm.nih.gov]

Hyperthyroidism

Children and adolescents may present with alterations in growth, including growth acceleration and advanced bone age; however, puberty is often delayed rather than precocious [merckmanuals.com]

Pseudohypoparathyroidism

X-rays will show shortening of the fourth metacarpal (long bone of the hand) and advanced bone age. [rarediseases.info.nih.gov]

Bone age is advanced by more than 2.0 s.d. beyond chronological age in 70–80% of patients with PHP1A 97, 215, 217, 218. [doi.org]

On radiographs, epiphyses display a cone shape, bone age is advanced and abnormalities might be present at birth or soon thereafter. [doi.org]

Astrocytoma

The presentation of the signs and symptoms of astrocytoma depends heavily on the tumor location and the extent of growth. Any neurological symptomatology detected in the early phase of the disease must prompt physicians to subject patients to further diagnostic tests and imaging studies to guide them with the[…] [symptoma.com]

Central Precocious Puberty

[…] who do not have extremely advanced bone age for chronological age. [ncbi.nlm.nih.gov]

Idiopathic central precocious puberty characterized by premature breast and public hair development and advanced bone age developed at the age of 20 months. [ncbi.nlm.nih.gov]

[…] before any lab draw, especially if bone age advanced. [hippoed.com]

Tuberculosis

INTRODUCTION: This study aimed to analyze social factors involved in the spatial distribution and under-reporting of tuberculosis (TB) in the city of Vitória, Espírito Santo State, Brazil. METHODS: This was an ecological study of the reported cases of TB between 2009 and 2011, according to census tracts. The[…] [ncbi.nlm.nih.gov]

Hyperpituitarism

OLS > Experimental Factor Ontology EFO > EFO:1000973 http://www.ebi.ac.uk/efo/EFO_1000973 Disease of the glandular, anterior portion of the pituitary (pituitary gland, anterior) resulting in hypersecretion of adenohypophyseal hormones such as growth hormone; prolactin; thyrotropin; luteinizing hormone; follicle[…] [ebi.ac.uk]

Craniopharyngioma

Endocrinology Metabolism By Pamela Jones, Brooke Swearingen, Brian Nahed Are You Sure the Patient Has a Craniopharyngioma? Craniopharyngiomas are benign tumors which develop in the sellar/suprasellar region adjacent to the pituitary gland. Patients may be diagnosed years after the onset of symptoms due to the[…] [endocrinologyadvisor.com]

Wiedemann-Steiner Syndrome

Here, we present a young girl with developmental delay, short stature despite a markedly advanced bone age, hypertrichosis without elbow hair, renal anomalies, and dysmorphic [ncbi.nlm.nih.gov]

[…] did not reveal advanced bone age. [frontiersin.org]

This patient expands the clinical phenotype associated with mutations in KMT2A to include variable patterns of hypertrichosis and a significantly advanced bone age with premature [ncbi.nlm.nih.gov]

Acrodysostosis

bone age, and mental retardation. [ncbi.nlm.nih.gov]

[…] with cone-shaped epiphyses, advanced bone-age, and variable degrees of mental retardation. [ncbi.nlm.nih.gov]

This may show any of the following: Advanced bone age Bone deformities in hands and feet Delays in growth Problems with the skin, genitals, teeth, and skeleton Short arms [nlm.nih.gov]

Aromatase excess syndrome

bone age. [ncbi.nlm.nih.gov]

Minor symptoms (variably advanced bone age and short adult height), if present, are exclusively because of estrogen excess. [ncbi.nlm.nih.gov]

Male patients with AEXS manifest pre- or peri-pubertal onset gynecomastia, gonadotropin deficiency, and advanced bone age, while female patients are mostly asymptomatic. [ncbi.nlm.nih.gov]

Precocious Puberty

KEYWORDS: Advanced bone age; Aortic root dilatation; Marshall-Smith syndrome; Novel pathogenic variant; Precocious puberty [ncbi.nlm.nih.gov]

[…] before any lab draw, especially if bone age advanced. [hippoed.com]

The patients had Tanner II to IV pubertal development, advanced bone age, an estrogen effect on vaginal smear, measurable basal gonadotropin levels with pulsed nocturnal secretion [ncbi.nlm.nih.gov]

Jeune Syndrome

Asphyxiating thoracic dystrophy is also known as Jeune syndrome, after the scientist who described it for the first time in 1855. It is a congenital disorder in which bone growth occurs in an abnormal manner, resulting in severe constriction of the chest, shortening of the ribs, as well as of the arm and leg bones,[…] [news-medical.net]

Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency

A 19 month-old female presented with isolated premature thelarche and significantly advanced bone age. [ncbi.nlm.nih.gov]

In the examined group vascular and metabolic abnormalities are pronounced more in certain subgroups of CAH (SV and SW: Del/Del) and in patients with advanced bone age. [ncbi.nlm.nih.gov]

Non salt losing CAH present late in childhood with precocious pubic hair and/or clitoromegaly, often accompanied by accelerated growth and advanced bone age. [quizlet.com]

Familial Testotoxicosis

The drug blocked the effects of testosterone, -but bone age advancement did not improve. [clinicaltrials.gov]

There is an advanced bone age? [slideplayer.com]

Showing of 13 | 80%-99% of people have these symptoms Accelerated skeletal maturation Advanced bone age Early bone maturation [ more ] 0005616 Male infertility 0003251 Precocious [rarediseases.info.nih.gov]

Simpson Dysmorphia Syndrome

[…] patient was not described, suggesting a lack of relationship between advanced bone age and advanced pubertal progression. [nature.com]

Advanced bone age. Bone age tells us how quickly a child's skeletal system is maturing. [medlexi.com]

Radiological findings include flare of iliac wings, narrow sacroiliac notches, and advanced bone age in one series. Prenatal diagnosis possible after 20 weeks. [accessanesthesiology.mhmedical.com]

Sotos Syndrome Type 1

OMIM® : 57 Sotos syndrome is a neurologic disorder characterized by overgrowth from the prenatal stage through childhood, with advanced bone age, an unusual face with large [malacards.org]

At 5 years, hand x ray showed slightly advanced bone age with dysharmonic maturation, phalangeal age being more advanced than carpal bone age. [jmg.bmj.com]

bone age. [ojrd.biomedcentral.com]