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592 Possible Causes for Advanced Bone Age

  • Tuberculosis

    Abstract Streptococcus anginosus forms a part of the commensal flora of the oral cavity. However, it can be aggressive and may lead to gastrointestinal and urogenital infections. We present an interesting case and course in a 38-year-old immunocompetent female patient with pyogenic liver abscess due to S.[…][]

  • Osteoporosis

    Similarly underappreciated contributors to bone loss in both men and women are advanced glycation end products (AGE’s); byproducts of high blood sugar.[] Contributory causes of these fractures include advanced age, female gender, falls, history of fractures associated with bone fragility, prolonged treatment with corticosteroids[] age.[]

  • Endocrine Dysfunction

    Bone age films should be obtained. Elevated LH-ICMA and FSH suggest primary hypogonadism.[] Girls without evidence of an advancing pubertal stage by 12 years and boys by 14 years require screening with LH-ICMA, FSH, and estradiol levels.[]

  • Sotos Syndrome

    Facial gestalt and macrocephaly, rather than advanced bone age, are the strongest indications for clinical diagnosis.[] Of these 18 children, 3 (17%) had an advanced bone age and were diagnosed with Sotos syndrome.[] Abstract Sotos syndrome, or cerebral gigantism, is a rare genetic condition characterized by tall stature, gigantism, dolichocephaly, advanced bone age and learning disability[]

  • Marshall-Smith Syndrome

    KEYWORDS: Advanced bone age; Aortic root dilatation; Marshall-Smith syndrome; Novel pathogenic variant; Precocious puberty[] Marshall-Smith syndrome is a rare congenital condition, characterized by advanced bone age, facial anomalies and relative failure to thrive.[] Marshall-Smith syndrome is characterized by advanced bone age, failure to thrive, respiratory problems, dysmorphic facial features, and variable mental retardation.[]

  • Weaver Syndrome

    Abstract Accelerated growth and advanced bone age are consistent findings in Weaver-Smith syndrome (WSS).[] In addition to the characteristic manifestations of overgrowth and advanced bone age, the facies were typical, with a broad forehead, hypertelorism, a long philtrum, micrognathia[] age.[]

  • Alstrom Syndrome

    One additional manifestation not described widely in the literature, advanced bone age, was observed in all subjects tested.[] bone age 15 years – adulthood 2 major and 2 minor criteria or 1 major and 4 minor criteria.[] Criteria Obesity and/or insulin resistance and/or Type 2 Diabetes History of dilated cardiomyopathy with congestive heart failure Hearing loss Hepatic dysfunction Renal failure Advanced[]

  • Acrodysostosis Type 1

    Individuals often have advanced bone age, may be obese and some are resistant to multiple hormones including parathyroid, calcitonin and growth hormone releasing hormone.[] ACRDYS1 is caused by heterozygous mutation in the PRKAR1A gene and is characterized by short stature, severe brachydactyly, facial dysostosis, nasal hypoplasia, advanced bone[] Abnormal vertebral size / shape - Advanced bone age - Broad nose / nasal bridge - Cone epiphyses / epiphysis - Depressed nasal bridge - Flattened nose - Hypoplastic maxillary[]

  • Generalized Lipodystrophy

    It is characterized by a lack of adipose tissue throughout the body from birth, muscular hypertrophy, advanced bone age, fatty liver, and insulin resistance.[] The clinical phenotype, viz. lack of subcutaneous fat, hepatosplenomegaly, cardiomegaly, and advanced bone age was also documented.[] Advanced bone age and linear growth and skeletal muscle prominence can be seen during childhood.[]

  • Central Precocious Puberty Type 2

    Bone age was advanced in all cases.[] Precocious puberty associated with hypothalamic hamartomas usually presents before 4 years of age and is associated with accelerated linear growth for age, advanced bone age[] However, In some girls, breast development is associated with definite evidence of systemic estrogen effects, such as growth acceleration or bone age advancement.[]

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