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308 Possible Causes for Advanced Bone Age, Short Stature in Children

  • Growth Hormone Deficiency

    Surprisingly, at 10.8 years, his bone age had advanced to 13 years, but physical exam, LH and testosterone levels remained prepubertal.[] Short stature is one of the clinical manifestations in these children.[] This can result in noticeably short stature in children.[]

  • Septo-Optic Dysplasia

    Marshall-Smith syndrome is characterized by advanced bone age, failure to thrive, respiratory problems, dysmorphic facial features, and variable mental retardation.[] Compared to other children referred for evaluation of short stature, children with SOD were younger (mean age 3.7 /- 3.6 vs 8.6 /- 4.9 years), had less severe short stature[] Her bone age at 9 years and 2 months was advanced (Japanese TW2 method, bone age of 10 years and 8 months). Her morning urine specific gravity was 1.010.[]

  • Pseudohypoparathyroidism

    We report three cases of primary osteoma cutis in children, two of whom (siblings) were associated with Albright's hereditary osteodystrophy (AHO), manifesting as short stature[]

  • Adrenogenital Syndrome

    In the female adrenogenital syndrome, the treatment of the urogenital sinus with high implanted vagina still presents a surgical challenge. The conventional technique (perineal vaginal pull-through) has been plagued by a high incidence of vaginal stenosis. A posterior sagittal transanorectal approach was proposed as[…][]

  • Skeletal Dysplasia

    Advanced bone age, increased stature and irregular epiphyseal ossification with stippling of the main long bones were documented.[] Two of the three children had skeletal anomalies resembling Desbuquois dysplasia: short stature, brachydactyly, dysmorphic facial features, and intellectual disability.[] With advancing age, platyspondyly became less conspicuous along with the development of thoracolumbar gibbus, the long bones showed dumbbell deformity and fluffy mega-epiphyses[]

  • Obesity

    Bone age is remarkably advanced in the younger (prepubertal) girl, and bone mineral density (BMD) is high in both girls, which might be directly or indirectly related to leptin[] Stunting or short stature in children is a significant nutritional problem in developing and underdeveloped countries.[] Several studies have shown that the increment risk of obesity and overweight in children with a short stature was due to their metabolic efficiency.[]

  • Congenital Hemihypertrophy

    The patient showed precocious puberty such as pubis and advanced bone age, but an endocrinological examination revealed no definite abnormalities.[] Abstract Two cases of a syndrome of hemihypertrophy, shortness of stature, and elevated levels of urinary gonadotropins are reported.[] The hemihypertrophy and shortness of stature had been present since birth and the elevated gonadotropins were found at 5½ and 6 years, respectively.[]

  • Aromatase excess syndrome

    bone age.[] As a result males have an early growth spurt, typically during late childhood, with short stature as an adult.[] Minor symptoms (variably advanced bone age and short adult height), if present, are exclusively because of estrogen excess.[]

  • Precocious Puberty

    The causes of advanced bone age in this syndrome are also reviewed. Additionally, the patient showed progressive dilatation of the aortic root.[] Gonadotropin-releasing hormone agonists should be considered only for children with progressive central precocious puberty to prevent short stature.[] Conclusion: Gonadotropin-releasing hormone analogue is effective in increasing FAH in Jordanian children with CPP, particularly those with advanced bone age.[]

  • Prader-Willi Syndrome

    Bone age advancement paralleled chronological age.[] In our case diagnosis of PWS was delayed because mental retardation, hypotonia, obesity and short stature were initially attributed to hypothyroidism.[] Short stature and short hands and feet are typical of PWS. Growth retardation is common and such children fail to thrive.[]

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