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35 Possible Causes for Age at Onset of Neurologic Features Variable

  • Progressive Myoclonic Epilepsy Type 7

    PMEs feature a combination of myoclonus, seizures, variable degree of cognitive impairment and other/focal neurological deficits [ 3 ].[ncbi.nlm.nih.gov] Age at onset varies from infancy to adulthood among different diseases and the course is progressive [ 2 ].[ncbi.nlm.nih.gov]

  • Subarachnoid Hemorrhage

    Clinical and Radiographic Variables We prospectively recorded baseline demographic data (age, sex), medical history, and clinical features at onset.[web.archive.org] A study neurologist performed a neurologic and general medical evaluation on admission.[web.archive.org]

  • Kohlschütter-Tönz Syndrome

    Based on the age at seizure onset, seizure type(s), brain MRI features, EEG patterns and disease course, distinct electroclinical syndromes can be defined within the group[doi.org] In addition, patients often present variable (non-) neurological comorbidities.[doi.org]

  • Alexander Disease

    […] signs were notably absent in about half of the affected members, and the age of onset of these neurological symptoms was variable.[jamanetwork.com] In turn, detailed examination of affected individuals revealed clinical features that were common to all affected individuals, but that have been rarely or never reported[jamanetwork.com] Previous studies of adult Alexander disease reported ataxia, palatal myoclonus, and pyramidal signs in many affected individuals. 11 - 14 However, in our study, these neurological[jamanetwork.com]

  • Niemann-Pick Disease Type C

    […] on the age at onset of neurological symptoms.[ncbi.nlm.nih.gov] We describe two patients with juvenile-onset Niemann-Pick disease type C (NPC) to illustrate the variable neurologic features of this condition.[ncbi.nlm.nih.gov] BACKGROUND: Niemann-Pick disease type C (NPC) is a rare, fatal neurovisceral disorder with autosomal recessive inheritance, and featuring striking clinical variability dependent[ncbi.nlm.nih.gov]

  • Mucopolysaccharidosis 2

    Mucopolysaccharidosis II affects multiple organs and physiologic systems and has a variable age of onset and variable rate of progression.[pediatrics.aappublications.org] […] enlargement and valvular dysfunction, and neurologic involvement.[pediatrics.aappublications.org] Common presenting features include excess urinary glycosaminoglycan excretion, facial dysmorphism, organomegaly, joint stiffness and contractures, pulmonary dysfunction, myocardial[pediatrics.aappublications.org]

  • Ataxia

    Clinical features Onset - Variable age of onset when younger than 20 years Neurologic symptoms - Cerebellar ataxia, dysarthria, nystagmus, uncoordinated limb movements, hypoactive[emedicine.medscape.com] Other postulated mechanisms to account for the differences include tissue-specific variability in triplet expansion size secondary to mitotic instability, cis -acting sequence[emedicine.medscape.com]

  • Niemann-Pick Disease Type B

    Systemic Features: Both the age of onset of neurological symptoms and the rate of progression are highly variable.[disorders.eyes.arizona.edu] However, by about 2 years of age visual responsiveness may be lost.[disorders.eyes.arizona.edu]

  • Spinocerebellar Ataxia Type 6

    Clinical features Onset - Variable age of onset when younger than 20 years Neurologic symptoms - Cerebellar ataxia, dysarthria, nystagmus, uncoordinated limb movements, hypoactive[emedicine.com] Other postulated mechanisms to account for the differences include tissue-specific variability in triplet expansion size secondary to mitotic instability, cis -acting sequence[emedicine.com]

  • Spinocerebellar Ataxia Type 13

    Clinical features Onset - Variable age of onset when younger than 20 years Neurologic symptoms - Cerebellar ataxia, dysarthria, nystagmus, uncoordinated limb movements, hypoactive[emedicine.com] Other postulated mechanisms to account for the differences include tissue-specific variability in triplet expansion size secondary to mitotic instability, cis -acting sequence[emedicine.com]

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