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1,446 Possible Causes for Agenesis of Corpus Callosum, Hypothyroidism

  • Septo-Optic Dysplasia

    At the age of 27 months hypothyroidism due to TSH deficiency developed. The auxological and neurological follow-up is reported.[ncbi.nlm.nih.gov] An uncommon association of infantile spasms, septo-optic dysplasia, partial agenesis of the corpus callosum and an interhemispheric cyst is described in a child.[ncbi.nlm.nih.gov] She was diagnosed with growth hormone deficiency, hypothyroidism, diabetes insipidus, and adrenal insufficiency. Thus, this case was regarded as septo-optic dysplasia.[ncbi.nlm.nih.gov]

  • Isolated optic nerve hypoplasia

    Tang PH, Bartha AI, Norton ME et al (2009) Agenesis of corpus callosum: an MR imaging analysis of associated abnormalities in the fetus.[link.springer.com] Children with untreated hypothyroidism are at high risk of mental retardation; thus, early detection is crucial.[ipfs.io] […] of the corpus callosum, dysplasia of the anterior third ventricle, and anomalies of the hypothalamic-pituitary axis.[eye.com.ph]

  • Growth Failure

    Thyroid hormone is necessary for normal growth; in children with hypothyroidism, growth is extremely slow.[emedicinehealth.com] Cranial defects may present with wide heads, flat noses, cleft lip/palate, hypertelorism, agenesis of the corpus callosum, hypopituitarism, posterior pituitary ectopia, basal[f1000research.com] However, treatment commenced in pubertal period may result in loss of adult height in cases with longstanding severe hypothyroidism.[abstracts.eurospe.org]

  • Hemochromatosis

    Over time, people with hereditary hemochromatosis may develop liver cirrhosis, liver cancer, heart disease, diabetes, arthritis, hypothyroidism, and impotence.[nybloodcenter.org] Salty Toe Length Ratio Unibrow Wake-Up Time Widow's Peak ARSACS 1 variant in the SACS gene; relevant for French Canadian descent Agenesis of the Corpus Callosum with Peripheral[23andme.com] […] year-round tan without being in the sun) • osteoarthritis or complaint of pain the first two knuckles of the hands (iron fist)osteoporosis (especially joint replacement) • hypothyroidism[irondisorders.org]

  • Young Simpson Syndrome

    This rare genetic disorder is characterized by congenital hypothyroidism, mental retardation and blepharophimosis.[ncbi.nlm.nih.gov] Also observed in GPS are flexion contractures of the hips and knees, clubfoot, agenesis of the corpus callosum with microcephaly, and hydronephrosis and/or multiple renal[ncbi.nlm.nih.gov] Some, but not all, children have heart problems and some have an absent midline structure of the brain (absent corpus callosum; see entry Agenesis of the Corpus Callosum )[contact.org.uk]

  • Growth Hormone Deficiency

    A positive thyroid autoantibody titer confirmed the diagnosis of chronic lymphocytic thyroiditis with hypothyroidism.[ncbi.nlm.nih.gov] Congenital Genetic (see “Genetics”) Structural brain defects Agenesis of corpus callosum Septo-optic dysplasia Empty sella syndrome Encephalocele Hydrocephalus Arachnoid cyst[unboundmedicine.com] Structural defects include agenesis of the corpus callosum, septo-optic dysplasia, empty sella syndrome, encephalocele, hydrocephalus, and arachnoid cyst.[emedicine.medscape.com]

  • Primrose Syndrome

    Additionally, she was born with Ebstein malformation, a congenital heart defect, agenesis of the corpus callosum, and hip dysplasia.[en.wikipedia.org] Review of the literature reveals another Primrose syndrome patient with hypothyroidism and thus, this may represent an under recognized component that should be investigated[ncbi.nlm.nih.gov] Additionally, she was born with Ebstein malformation , a congenital heart defect , agenesis of the corpus callosum , and hip dysplasia .[en.wikipedia.org]

  • Monosomy 1p36 Syndrome

    Other features commonly associated are behavioural anomalies including hyperphagia and self-injuring, seizures, congenital heart disease and hypothyroidism.[ncbi.nlm.nih.gov] Affiliated tissues include brain, heart and eye, and related phenotypes are agenesis of corpus callosum and intellectual disability Genetics Home Reference : 26 1p36 deletion[malacards.org] When diagnosed, hypothyroidism can be treated successfully with medication.[1p36dsa.org]

  • Hypopituitarism

    Antithyroid antibodies, in the normal range three months postpartum, became significantly elevated when the hypothyroidism appeared.[ncbi.nlm.nih.gov] HESX1 HESX1 mutations result in septo-optic dysplasia (pituitary hypoplasia, optic nerve hypoplasia, and midline defects such as agenesis of the corpus callosum).[endocrinologyadvisor.com] The condition is defined loosely by any combination of the triad of optic nerve hypoplasia (ONH), midline neuroradiological abnormalities (such as agenesis of the corpus callosum[web.archive.org]

  • Thalassemia

    After exclusion of familial triglyceridemia and secondary causes (hypothyroidism, nephrotic syndrome, drugs etc.), a diagnosis of hypertriglyceridemia thalassemia syndrome[ncbi.nlm.nih.gov] In two cases, partial or complete agenesis of the corpus callosum was reported. Autopsy reports were available for only three cases.[ojrd.com] These include bone marrow expansion, toxicity from iron overload and iron chelation, endocrine dysfunctions (hypogonadism, hypohyperparathyroidism, hypothyroidism, growth[ncbi.nlm.nih.gov]

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