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2 Possible Causes for Aggregates Contain Granular Electron Dense Material

  • Leigh's Disease

    Fine granular electron-dense material was seen in the matrix, but paracristalline inclusions and large spherical dense bodies were absent.[] The mitochondria contained an excessive number of irregularly arranged and distorted cristae.[] […] gene mutation was identified in this patient. 50 The dominant ultrastructural feature of this case was enlarged mitochondria of bizarre shape and various size and form, aggregated[]

  • Multicore Myopathy

    Ultrastructurally, many areas devoid of mitochon- dria, but with normal myofibrils, were present; electron- dense granular material between myofibrils bordered by small aggregates[] The mitochondria-free regions could contain some abnor- mal sarcomeres, which were transversely rather than long- itudinally located.[]

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