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117 Possible Causes for Airway Obstruction, Coarse Facial Features, Coronary Artery Disease

  • Mucopolysaccharidosis

    Severe coronary artery disease is well recognized in severe type I mucopolysaccharidosis (Hurler syndrome), but unexpected coronary artery disease occurs in other, "non-Hurler[] Although upper airway obstruction was noted, it resolved with simple airway maneuvers without further airway intervention. 2017 John Wiley & Sons Ltd.[] facial features, developmental delay, and an elevated quantitative urine glycosaminoglycan (GAG) level.[]

  • Fabry Disease

    , ventricular tachycardia, atrial fibrillation and coronary artery disease).[] Pulmonary There can be chronic obstructive airways disease like symptoms with bronchial wall thickening.[] Often patients have slight builds with characteristic coarse facial features and delayed puberty.[]

  • Mucopolysaccharidosis 2

    Oropharyngeal and tracheobronchial deposition of glycosaminoglycans results in airway obstruction due to macroglossia, supraglottic narrowing, and tracheomalacia.[] Other symptoms may include carpal tunnel syndrome, coarse facial features, deafness, hairy body (hypertrichosis), joint stiffness, and a large head (macrocephaly).[] A thickened myocardium eventually leads to coronary artery compromise, myocardial disease, and, in conjunction with airway disease, pulmonary hypertension.[]

  • Mucopolysaccharidosis 1

    Progressive upper airway disease leads to obstructive sleep apnoea.[] Further common findings are coarse facial features, carpal tunnel syndrome, umbilical and inguinal hernia, and hepatomegaly.[] Caution should be exercised if epinephrine is being considered for use in patients with MPS I due to the increased prevalence of coronary artery disease in these patients.[]

  • Mucopolysaccharidosis 1H

    : early onset severe regurgitation and stenosis coronary artery disease cardiomegaly: initially hypertrophic then dilated Other features include prominent perivascular spaces[] Within 24 months, his mean pulmonary artery pressure was within the upper limit of normal and interstitial lung disease and airway obstruction improved markedly.[] […] hairy skin all over the body, a tuft of hair in the parietal region, coarse facial features and a prominent forehead with a large tongue, hepatosplenomegaly and skeletal[]

  • Launois Syndrome

    In a 15-year follow-up of 70 patients, sudden death, in the absence of coronary heart disease, was recorded in three out of 11 patients, related to severe autonomic neuropathy[] Lipomas can cause respiratory distress due to bronchial obstruction of major airways, GI obstruction or bleeding, neuropathic symptoms from compression in locations such as[] […] or digestive tract obstruction, if necessary.[]

  • Hypothyroidism

    Airway obstruction by a goiter can be reliably assessed with whole-body plethysmography ( 4 ).[] Other findings may include pale, yellow skin, thin and brittle hair, coarse facial features, brittle nails, firm swelling of the arms and legs, and mental slowing.[] However, treatment should be initiated at a low dose in elderly patients, patients with coronary artery disease and patients with long-standing severe hypothyroidism.[]

  • Sick Sinus Syndrome

    A 62-year-old woman had acromegaly and developed congestive heart failure with cardiomyopathy, mitral regurgitation due to chordae rupture, coronary artery disease and sick[] In addition, in those with choanal atresia, surgery or other appropriate methods may be required to decrease the airway obstruction or correct the malformation.[] If a patient is on a class 1C antiarrhythmic drug and develops coronary artery disease, the drug should be discontinued.[]

  • Mucopolysaccharidosis 4

    artery disease, and other vascular involvement occurring very early in life and, if unrecognized and untreated, contributing significantly to early mortality [ 2 ].[] Premedicants are best avoided because of dangers of upper airway obstruction, respiratory depression, hypercarbia and cardiorespiratory arrest.[] Patients may also have coarse facial features, although this is usually milder than that seen in MPSI or MPSII.[]

  • Acromegaly

    Most deaths result from heart failure, coronary artery disease and hypertension-related causes.[] Additionally, female patients showed signs of subclinical airway obstruction.[] A 30-year-old Filipino man presented with a 11-year history of coarse facial features and progressive enlargement of hands and feet.[]

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