Possible Causes for albumin decreased Food Allergy Features of FPE are nonbloody diarrhea, malabsorption, protein-losing enteropathy, hypoalbuminemia, and failure to thrive. [ncbi.nlm.nih.gov] Substance Abuse Abstract Hospital-wide rumors and anecdotal reports had suggested that there was a potentially serious problem of alcohol and drug abuse among the psychiatric patients of this hospital. The authors describe a systematic, evaluative approach which gave direct and detailed information on the nature and extent of[…] [ncbi.nlm.nih.gov] Esophagitis Esophagitis is an inflammation of the lining of the esophagus, the tube that carries food from the throat to the stomach. If left untreated, this condition can become very uncomfortable, causing problems with swallowing, ulcers, and scarring of the esophagus. In some instances, a condition known as Barrett's[…] [webmd.com] Gastritis Partial or complete gastric resection may be necessary in cases of severe hypoalbuminemia. [web.archive.org] Variable findings sometimes associated with GHG include low levels of the protein albumin (hypoalbuminemia), which may result in fluid accumulation (edema) in the stomach. [rarediseases.org] Hypoalbuminemia (the most consistent laboratory abnormality) caused by GI protein loss may be present (protein-losing gastropathy). [web.archive.org] Third Trimester Pregnancy The concomitant phenomenon of a third trimester pregnancy with a significant degree of pelvic organ prolapse is extremely rare. We report on a patient with pelvic organ prolapse complicating third trimester pregnancy treated by concomitant cesarean hysterectomy and abdominal sacrocolpopexy. A 30-year-old woman,[…] [ncbi.nlm.nih.gov] Cholestatic Jaundice Proteins: Albumin: Decreased – advanced cirrhosis & signify severe hepatic dysfunction. [slideshare.net] Serum albumin is usually normal except in cirrhosis and chronic liver disease where albumin is decreased. [ncbi.nlm.nih.gov] Heart Failure Chronic venous congestion in the viscera can cause anorexia, malabsorption of nutrients and drugs, protein-losing enteropathy (characterized by diarrhea and marked hypoalbuminemia [msdmanuals.com] Gámez-López, Mirian Moreno-Conde, María Cristina López-Ibáñez, Manuel Anguita-Sánchez, Ángel Gallego de la Sacristana, Francisco García-Catalán and Antonia Villar-Ráez, Hypoalbuminemia [dx.doi.org] Psoriasis Other possible complications in pustular psoriasis include the following: Secondary bacterial skin infections, hair loss ( telogen effluvium ), and nail loss Hypoalbuminemia [emedicine.com] […] and therefore require close monitoring, are those who have renal insufficiency, the elderly, those at risk for drug interactions or taking multiple medications, those with hypoalbuminemia [doi.org] secondary infection, septicemia, hyperparathyroidism with hypocalcemia, hypoalbuminemia) may occur. 1 Figure 6. Impetigo herpetiformis on the leg. [aafp.org] Liver Cirrhosis When liver function decreases, the value of albumin also decreases. [otsuka.co.jp] Increasing Child score, INR and decreasing albumin were correlated with TO. In addition, decompensated patients with ascites showed more abnormal TO and TS. [ncbi.nlm.nih.gov] Thus, there is a frequent lack of BCAAs in LC patients, resulting in decreased albumin synthesis. [wjgnet.com] Burn Injury The real problem in burn treatment is hypoalbuminemia. [ncbi.nlm.nih.gov] The level of albumin is reduced, causing a decrease in the binding fraction of drugs which bind primarily with albumin, such as the benzodiazepines and the antiepileptic drugs [medbc.com] Alkaline phosphatase is a zinc-dependent enzyme and can be decreased in zinc deficiency. [dermatologyadvisor.com] Hemochromatosis […] polyhydramnios. 6, ,7 Illness usually is evident within hours of birth, although some have been diagnosed at a few weeks of age. 6, ,8 Patients have features of liver failure with hypoalbuminemia [pediatrics.aappublications.org] Preeclampsia Other factors helpful in making the diagnosis are hemoconcentration, hyperreflexia, hypoalbuminemia, liver function abnormalities, thrombocytopenia, and hyperuricemia. [healthcentral.com] It may also be related to decreased plasma colloid oncotic pressure from proteinuria, use of crystalloids to replace blood loss, and decreased hepatic synthesis of albumin [health.am] Cronkhite-Canada Syndrome Serum protein electrophoresis revealed a decrease in the albumin fraction in 50% of patients and elevation of α1, globulin in 59.1%. [kjim.org] Serum protein electrophoresis revealed a decrease in the albumin fraction in 50% of patients and elevation of α 1, globulin in 59.1%. [kjim.org] Here we report a 63-year-old male presenting with diffuse gastrointestinal polyposis, onychodystrophy, cutaneous pigmentation, alopecia, diarrhea, hypoalbuminemia and lower [ncbi.nlm.nih.gov] Polymyalgia Rheumatica Anemia of chronic disease, leukocytosis, reactive thrombocytosis, and decreased albumin are also common. Alkaline phosphatase and hepatic enzymes may be elevated. [rheumaknowledgy.com] An electrophoresis analysis using a blood sample revealed a decrease in albumin with no signs of monoclonal peaks. [revistanefrologia.com] Other laboratory signs of inflammation may include: thrombocytosis, leukocytosis, anemia, hypoalbuminemia, polyclonal hypergammaglobulinemia, and an elevated ferritin. [rheumatologyadvisor.com] Portal Cirrhosis […] platelets Splenomegaly Reduced hepatic production of thrombopoietin Direct toxic effect of alcohol on the bone marrow Albumin Decreased in advanced cirrhosis Decreased hepatic [pathophys.org] Nail changes: – Muehrcke's nails: Paired horizontal bands separated by normal color due to hypoalbuminemia,[8] from inadequate production of albumin, which is solely made [slideshare.net] Albumin will decrease and this is a marker for reduced synthetic function of the liver. [kenhub.com] Hepatitis Depending on the degree of liver injury, lab values may indicate depressed liver function (e.g. decreased albumin). [radiopaedia.org] A low zinc level, hypoalbuminemia, and low blood urea nitrogen may indicate malnutrition[ 18 ]. [doi.org] Many other conditions also affect albumin level. Total protein – albumin and all other proteins in blood; may be decreased with severe liver disease. [labtestsonline.org] Glomerulonephritis Signs and symptoms of nephrotic syndrome include massive proteinuria (greater than 3 grams of protein loss per day), hypoalbuminemia, hyperlipidemia, weight gain, noticeable [youtube.com] Urinary protein exertion was decreased, and serum level of complement and albumin was increased. [ncbi.nlm.nih.gov] Oedema periorbital* Hypoalbuminaemia due to albumin loss in urine (glomerulonephritis) Aldosterone. 7. [slideshare.net] Macronodular Cirrhosis Serum albumin: significant liver disease results in hypoalbuminemia. 10. [encyclopedia.lubopitko-bg.com] decreased in chronic liver diseases. prothrombin time: increased in acute and chronic liver diseases. [quizlet.com] Protein metabolism tests show decreased total protein, decreased albumin, and increased globulin. [medical-dictionary.thefreedictionary.com] Pseudomembranous Colitis Investigations FBC - Increased WBC LFT – decreased albumin EUC/CMP – electrolyte disturbance and renal dysfunction Lactate Stool cultures - unformed stool only AXR – thumbprinting [aci.health.nsw.gov.au] On admission, leukocytosis was found in 79% of patients, 20,000/mm3 in half of them; 60% were anemic, 60% had elevated erythrocyte sedimentation rate, and 78% had hypoalbuminemia [ncbi.nlm.nih.gov] Features considered nonspecific but suggestive of Clostridium difficile infection include leukocytosis, hypoalbuminemia and faecal leukocytes and occult blood. [histopathology-india.net] Septicemia Effect of hypoalbuminemia and parenteral nutrition on free water excretion and electrolyte-free water resorption. Crit Care Med 1992 ; 20 : 164 -9. [bmj.com] Hypoalbuminemia in acute illness: is there a rationale for intervention? A meta-analysis of cohort studies and controlled trials. Ann Surg 2003 ; 237 : 319 -34. [bmj.com] Cryptogenic Cirrhosis Muehrcke's lines – paired horizontal bands separated by normal color resulting from hypoalbuminemia (inadequate production of albumin). [en.wikipedia.org] Decreased serum albumin and a prolonged prothrombin time (PT) directly reflect impaired hepatic synthesis—usually an end-stage event. [merckmanuals.com] Cirrhosis Fulminant hepatic failure Veno-occlusive disease Extrahepatic portal hypertension Hepatic vein obstruction (ie, Budd-Chiari syndrome) Congestive heart failure Hypoalbuminemia [hepatitiscnewdrugs.blogspot.com] Nephrotic Syndrome See also nephrosis. neph·rot·ic syn·drome a clinical state characterized by edema, albuminuria, decreased plasma albumin, doubly refractile bodies in the urine, and usually [medical-dictionary.thefreedictionary.com] Proteinuria and hypoalbuminemia Immune system The hallmark of INS is massive proteinuria, leading to decreased circulating albumin levels. [emedicine.com] Synonym(s): nephrotic syndrome neph·rot·ic syn·drome ( nef-rot'ik sin'drōm ) Clinical state characterized by edema, albuminuria, decreased plasma albumin, doubly refractile [medical-dictionary.thefreedictionary.com] Hepatocellular Carcinoma Discussions In this case study, it was observed that the levels of total protein decreased with concomitant decrease in albumin levels and increased in globulin levels. [jbiomeds.com] Common lab abnormalities include: thrombocytopenia, hypoalbuminemia, hyperbilirubinemia, and an elevated serum INR. [clinicaladvisor.com] […] hypertension may result in hypersplenism with platelet sequestration, thrombocytopenia, esophagogastric varices and GI bleeding, hepatic encephalopathy, hypotension, and hypoalbuminemia [doi.org] Pancreatic Insufficiency Over time, weight loss, anorexia, muscle wasting and flatulence ensue, while severe cases suffer from profound hypoalbuminemia that can manifest with leukonychia. [symptoma.com] Nail leukonychia due to hypoalbuminemia may be present in the late stages of chronic malabsorption. [dx.doi.org] […] control; Single small stool sample Sensitivity low for clinical practice (chymotrypsin is variably inactivated during intestinal transit); not for mild EPI; watery stools decrease [dx.doi.org] Capillary Leak Syndrome Laboratory data showed an increase in hematocrit (65%), leucocytes (24.590 μ/L), creatinine (2.5 mg/dL), creatine phosphokinase (10.000 U/L), and a decrease in serum albumin [ncbi.nlm.nih.gov] The sudden and profound capillary leak causes a sharp decrease in serum albumin level (hypoalbuminemia) and a similarly sharp increase in the level of hemoglobin and hematocrit [rarediseases.org] With an increase in the albumin level, the swelling of the extremities decreased, although muscle ache (compartment pressure of the posterior calf and volar forearm was 10 [ceemjournal.org] Viral Hepatitis An ultrasound obtained for evaluation of a prolonged prothrombin time and decreased serum albumin level showed a suspicious nodular lesion in the left lobe of the liver. [ncbi.nlm.nih.gov] a diagnosis of cirrhosis was made if histologic findings of hepatic fibrosis were observed in conjunction with clinical evidence of severe hepatic dysfunction (such as hypoalbuminemia [bmcgastroenterol.biomedcentral.com] As liver disease progresses, laboratory results consistent with decreased synthetic function of the liver may include an elevated International Normalized Ratio with hypoalbuminemia [journals.lww.com] Inflammatory Bowel Disease Type 1 Elemental diet and anti-TNFα agent improved his hypoalbuminemia after surgery. [ncbi.nlm.nih.gov] Girls had a higher prevalence of mouth sores and hypoalbuminemia at diagnosis, and they were at greater risk for erythema nodosum/pyoderma gangrenosum and for a first intestinal [web.archive.org] Laboratory parameters reveal normocytic, normochromic anemia, vitamin deficiency, hypoproteinemia and hypoalbuminemia. [orpha.net] Celiac Disease CASE PRESENTATION: We report a 3-year girl with chronic diarrhea, Hypoalbuminemia and exfoliative erythema. [ncbi.nlm.nih.gov] The initial laboratory tests revealed anemia, leukocytosis, increased inflammatory biomarkers, high levels of transaminases, and hypoalbuminemia. [ncbi.nlm.nih.gov] […] in albumin levels, and intestinal obstruction. [emedicinehealth.com] Minimal Change Nephropathy A satisfactory response characterized by correction of hypoalbuminemia, clearance of proteinuria, and an increase of endogenous creatinine clearance occurred with corticosteroid [ncbi.nlm.nih.gov] Nephrotic range proteinuria without severe hypoalbuminemia was detected during the 25-day course of oliguric renal failure. Renal vein thrombosis was excluded. [ncbi.nlm.nih.gov] Proteinuria, hypoalbuminemia, generalized edema, hyperlipidemia, and hypercholesterolemia). [pathwaymedicine.org] Protein-Losing Enteropathy However, the correlation between the decrease in serum albumin and liver function is far from linear and arguments in favor of an additive role of protein-losing enteropathy [ncbi.nlm.nih.gov] After the heart transplantation, the albumin level decreased to 2.3 g/dl, and therefore it was restarted. [ncbi.nlm.nih.gov] This clinical condition should be suspected in the presence of persistent hypoalbuminemia despite normal liver function, adequate protein intake, and no significant proteinuria [ncbi.nlm.nih.gov]
