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12 Possible Causes for Albumin Decreased, Alpha Interferon Activity Increased, Thrombocytopenia

  • Systemic Lupus Erythematosus

    Background While thrombopoeitin (TPO) agonists that act to simulate platelet production have been approved for use in steroid-refractory chronic immune thrombocytopenia purpura[ncbi.nlm.nih.gov] In some systemic lupus erythematosus studies, heart rate variability was found to correlate with inflammatory markers and albumin levels.[ncbi.nlm.nih.gov] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.com]

  • Chronic Active Hepatitis

    Onset was signalled by an abrupt and dramatic thrombocytopenia, which was also the only laboratory parameter able to monitor treatment and progression of the disease.[ncbi.nlm.nih.gov] Corticosteroid therapy also lead to improvement in biochemical abnormalities (decrease bilirubin and aminotransferase level and increase albumin) as well as decrease in the[hepatitiscentral.com] CONCLUSIONS: alpha-interferon therapy for patients with chronic active hepatitis B is cost effective. alpha-Interferon is more cost effective in toddlers than adults because[ncbi.nlm.nih.gov]

  • Infectious Mononucleosis

    They include Granulocytopenia Thrombocytopenia Hemolytic anemia Transient mild granulocytopenia or thrombocytopenia occurs in about 50% of patients; severe cases, associated[merck.com] The most commonly seen abnormalities in the paper electrophoretic patterns of sera obtained from patients with infectious mononucleosis were decreased albumin, increased gamma[link.springer.com] Th1 lineage mostly produce type 2 interleukin (IL-2), interferon-gamma (INF-γ) and tumor necrosis factor-alpha (TNF-α).[omicsonline.org]

  • Alcoholic Hepatitis

    These findings suggest that PAIgG may have been involved in the development of thrombocytopenia in this patient.[ncbi.nlm.nih.gov] He was able to increase his albumin and decrease his international normalized ratio (INR) to the normal ranges, increase healthy eating and regain weight, and resolve the[hepatitis.va.gov] We analyzed clinical, biological, virological and histological features in two cases where alpha-interferon treatment for HCV-related hepatitis led to a marked increase in[ncbi.nlm.nih.gov]

  • Lupus Erythematosus

    […] autoimmune thrombocytopenia).[merckmanuals.com] . • Serum protein electrophoresis : increased gammaglobulin and decreased albumin. • Routine blood counts: anemia and low platelet and white cell counts. • Routine blood chemistry[slideshare.net] The generation of polyclonal T-cell cytolytic activity is impaired. Helper (CD4 ) T cells are increased. A lack of immune tolerance is observed in animal lupus models.[emedicine.medscape.com]

  • HIV Infection

    As part of the work up for thrombocytopenia, a rapid HIV antibody based assay was done and was negative.[ncbi.nlm.nih.gov] The standard urinary dipstick is a sufficient screen for proteinuria, but diabetic patients must be tested for microalbuminuria, defined as urinary albumin excretion of 30[academic.oup.com] […] are not generally increased, although expression of IL-1, IL-2, IL-6, IL-12, and interferon-gamma may be elevated.(112) With administration of antiretroviral therapies, these[hivinsite.ucsf.edu]

  • Chronic Active Hepatitis B

    Diseases commonly seen with autoimmune hepatitis include hemolytic anemia, immune thrombocytopenia, type 1 diabetes mellitus, thyroiditis, celiac sprue, ulcerative colitis[clinicaladvisor.com] Corticosteroid therapy also lead to improvement in biochemical abnormalities (decrease bilirubin and aminotransferase level and increase albumin) as well as decrease in the[hepatitiscentral.com] CONCLUSIONS: alpha-interferon therapy for patients with chronic active hepatitis B is cost effective. alpha-Interferon is more cost effective in toddlers than adults because[ncbi.nlm.nih.gov]

  • Waters-West Syndrome

    The most common cause of thrombocytopenia during pregnancy is gestational thrombocytopenia, which is a mild thrombocytopenia with platelet levels remaining above 70,000/µL[emedicine.medscape.com] […] intracapillary oncotic pressure hepatic synthesis of albumin may be imparaired because of hepatic hypoperfusion, increased extramedullary hematopoisis, storage diseases and[atlases.muni.cz] Laboratory evaluation shows increased alpha-interferon ( IFNA1 ) activity with upregulation of interferon signaling and interferon-stimulated gene expression.[mendelian.co]

  • Familial Hemophagocytic Lymphohistiocytosis

    Other significant findings include hepatosplenomegaly, progressive anemia, leukopenia, thrombocytopenia, hyperlipidemia and hypofibrinogenemia.[ncbi.nlm.nih.gov] Cytompenia, elevated serum transaminase and low serum albumin levels, hypertriglyceridemia were common laboratory findings of them.[kjp.or.kr] […] expression of tumor necrosis factor-alpha and interferon-gamma, leading to increased macrophage activation.[healio.com]

  • Interferon Beta-1a

    At admission, there was elevation of transaminases, anemia (hemoglobin 8.9 g/dL), thrombocytopenia (platelet 135,000/mm3), and hypofibrinogenemia (fibrinogen 1.26 g/L).[ncbi.nlm.nih.gov] Infection—May decrease your body's ability to fight an infection.[drugs.com] In addition, interferon beta may bind to a distinct receptor that does not interact with interferon alpha.[iqb.es]

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