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97 Possible Causes for Aldolase Increased

  • Duchenne Muscular Dystrophy

    The level of serum aldolase, an enzyme involved in the breakdown of glucose, is measured to confirm a diagnosis of skeletal muscle disease.[web.archive.org] Levels are significantly increased in the early stages of Duchenne and Becker MD. Testing can also determine if a young woman is a carrier of the disorder.[web.archive.org]

  • Polycystic Ovary Syndrome

    […] has been found to be increased in ovarian tissue and in ovarian granulosa cells from PCOS patients.[doi.org] The abundance of many proteins such as aconitate hydratase, fructose bisphosphate aldolase A, malate dehydrogenase, isoenzymes M1/M2 of pyruvate kinase, and transaldolase[doi.org]

  • Polymyalgia Rheumatica

    Enzymes that reflect muscle inflammation, such as creatine kinase and aldolase, are normal.[reliasmedia.com] […] one-quarter of patients, and one-third are hypoalbuminemic. 37 Increased prothrombin has been reported.[reliasmedia.com] Only 1.4% of polymyalgia rheumatica patients present with normal ESR and normal C-reactive protein. 32 Liver enzymes, especially alkaline phosphatase, are increased in approximately[reliasmedia.com]

  • Hypoxia

    It does this by increasing the expression of glycolytic enzymes, such as hexokinase, phosphofructokinase, aldolase, phosphoglycerate kinase 1, enolase, and lactate dehydrogenase[jasn.asnjournals.org]

  • Muscular Dystrophy

    The level of serum aldolase, an enzyme involved in the breakdown of glucose, is measured to confirm a diagnosis of skeletal muscle disease.[web.archive.org] Levels are significantly increased in the early stages of Duchenne and Becker MD. Testing can also determine if a young woman is a carrier of the disorder.[web.archive.org]

  • Lafora Disease

    Treatment: Arginine Laboratory CK: High after exercise & anesthesia; Near normal otherwise EMG: Normal Muscle pathology Fiber size: Variable Lipid: Increased EM: Distorted[neuromuscular.wustl.edu] […] mitochondria; Lipid accumulations Aldolase A activity: Reduced β-Enolase deficiency (GSD 13) 3 Enolase-3 (ENO3) ; Chromosome 17p13.2; Recessive Epidemiology: 3 patients Genetics[neuromuscular.wustl.edu]

  • Benzodiazepine Withdrawal

    For example, patients with NMS may have rhabdomyolysis, resulting in significant increases in serum creatine kinase, aldolase, transaminases, and lactic acid dehydrogenase[doi.org]

  • Sarcoidosis

    […] creatine phophokinase (CK/aldolase) which decreases with treatment Increased creatine phosphokinase (CK/aldolase) Myalgias responding to treatment Because sarcoidosis is[doi.org] […] granulomatous involvement New-onset sinusitis New-onset dizziness Parotic/salivary glands Symmetrical parotidtis with syndrome of mumps Dry mouth Positive gallium scan Muscles Increased[doi.org]

  • Rhabdomyolysis

    While increased aldolase levels are not as specific or as sensitive for muscle disease as CK levels, increased aldolase together with an increased CK level is highly suggestive[dx.doi.org] Aldolase is another glycolytic pathway enzyme that is found in high concentration in skeletal muscle, the liver and the brain.[dx.doi.org] For example, carbonic anhydrase III is present in skeletal muscles but not in myocardium, and an increase in its levels is more specific for skeletal muscle injury than are[dx.doi.org]

  • X-linked Distal Spinal Muscular Atrophy Type 3

    Serum enzymes (eg, CK, aldolase) may be slightly increased. Amniocentesis, done if family history is positive, is often diagnostic.[merckmanuals.com]

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