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27 Possible Causes for Alkaline Phosphatase Increased, Bicytopenia

  • Gaucher Disease

    Summary Epidemiology The prevalence is approximately 1/100,000. The annual incidence of GD in the general population is about 1/60,000, but it can reach up to 1/1,000 in Ashkenazi Jewish populations. Clinical description The clinical manifestations of this disease are highly variable. GD type 1 (90% of cases) is the chronic[…][orpha.net]

  • Sepsis

    DIAGNOSIS: The present patient met 5 of the HLH criteria: fever, splenomegaly, bicytopenia, hypertriglyceridemia and/or hypofibrinogenemia, and hyperferritinemia.[ncbi.nlm.nih.gov]

  • Hepatosplenic Lymphoma

    There was bicytopenia (hemoglobin - 101 g/L, platelet count - 38 10 9 /L, and total leukocyte count - 5 10 9 /L) with only a few blasts in peripheral blood film [Figure 1][ijpmonline.org] It can be easily misdiagnosed as acute leukemia on morphology as well as flow-cytometry, though massive hepatosplenomegaly with bicytopenia and no lymphadenopathy is highly[ijpmonline.org]

  • Systemic Mastocytosis

    Although the patient responded to the treatment, the relapse with splenomegaly and bicytopenia was observed after 10 months.[ncbi.nlm.nih.gov] In multivariate analysis of all patients, an increased spleen volume 450 ml (hazard ratio (HR), 5.2; 95% confidence interval (CI), (2.1-13.0); P 0.003) and an elevated alkaline[ncbi.nlm.nih.gov] Preoperative laboratory investigations were normal, except for moderate anemia (hemoglobin 99 g/L), increased alkaline phosphatase (196 U/L, normal 36-108 U/L), and decreased[journals.lww.com]

  • Pseudogout

    Minor adverse events (AE) did not differ in frequency between the groups, but the only serious AE occurred on MTX (bicytopenia).[ncbi.nlm.nih.gov] […] of alkaline phosphatase and γ- glutamyltransferase, normal iron studies, negative rheumatoid factor, positive antinuclear antibody (1/320 homogeneous pattern), negative extractable[ard.bmj.com] TNF-alpha and IL1-beta inhibits RUNX2 and collagen expression but increase alkaline phosphatase activity and mineralization in human mesenchymal stem cells.[doi.org]

  • Paraneoplastic Syndrome

    More on polymyalgia rheumatica (PMR) as a paraneoplastic rheumatic syndrome in the elderly (bicytopenia and PMR preceding acute myeloid leukemia).[medical.nikkeibp.co.jp] […] serum alkaline phosphatase levels, and elevated or normal serum FGF-23 levels.[ncbi.nlm.nih.gov] […] main biochemical manifestations of this disorder include hypophosphatemia, inappropriately low or normal tubular reabsorption of phosphate, low serum calcitriol levels, increased[ncbi.nlm.nih.gov]

  • Refractory Anemia

    Diagnosis Comment: There is leukocytosis and bicytopenia (normocytic anemia and thrombocytopenia).[gpec.ubc.ca] Decreased myeloperoxidase and alkaline phosphatase activity 58 Thrombodysplasia Thrombocytopenia and Large , atypical platelets 59 Bone Marrow Erythrodysplasia : Leucodysplasia[slideplayer.com] MDS Type Blood Marrow Refractory cytopenia with unilineage dysplasia (RCUD) Refractory anemia (RA) Refractory neutropenia (RN) Refractory thrombocytopenia (RT) Uni- or bicytopenia[slideshare.net]

  • Leukemoid Reaction

    Infection induced hemophagocytic lymphohistiocytosis with a leukemoid reaction was suspected because of fever, splenomegaly and bicytopenia in conjunction with elevated serum[ncbi.nlm.nih.gov] Unlike CML, leukocyte alkaline phosphatase is increased and the bcr/abl translocation is absent.[wakemedicine.wordpress.com] In addition, an increased alkaline phosphatase level suggested true leukemoid reaction.[synapse.koreamed.org]

  • Leukoerythroblastic Anemia

    Pancytopenia was seen in 9.55% (17) cases and bicytopenia in 50.5% (90) patients.[jahjournal.org] phosphatase (LAP) score is increased Treatment Reduced intensity allogeneic stem cell transplant if intermediate to high risk or palliation of extramedullary hematopoiesis[pathologyoutlines.com] The leukocyte alkaline phosphatase score is normal or increased, and the karyotype of remaining normal marrow cells is intact.[medtextfree.wordpress.com]

  • Evan's Syndrome

    The pattern of occurrence of bicytopenia can delay the diagnosis since it may be coincidental, sequential, or separate, and the time frame between episodes can range from[symptoma.com] […] bilirubin with normal alkaline phosphatase suggests constitutional hyperbilirubinemias or hemolytic crisis. [10] An elevated aspartate transferase (SGPT) alone can be of[ijem.in] […] by its immune system. [9] A rise in serum bilirubin greater than 5 mg/dl seldom occurs in uncomplicated hemolysis unless hepatobiliary disease is also present, however, increased[ijem.in]

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