Create issue ticket

2,573 Possible Causes for Alkaline Phosphatase Increased, Complete Blood Count Abnormal, Liver Biopsy showing Periportal Necrosis

  • Massive Hepatic Necrosis

    A, intraoperative (POD 0) wedge biopsy of the native liver showed massive hepatic necrosis and periportal ductular structure (HE, 200 ).[nature.com] […] elevation of serum alkaline phosphatase and bilirubin.[annals.org] […] in alkaline phosphatase, and a greatly prolonged prothrombin time, which was unresponsive to the parenteral administration of vitamin K.[nap.edu]

  • Viral Hepatitis

    Hepatosplenomegaly and laboratory evidence of mild to moderate hepatic dysfunction are the predominant features, with increased aminotransferases and alkaline phosphatase[doi.org] Alkaline phosphatase (ALP) – an enzyme related to the bile ducts but also found in other tissues throughout the body.[labtestsonline.org] The ALP test is often increased when bile ducts are blocked but may also be increased with bone disorders.[labtestsonline.org]

  • Hepatitis B

    […] serum alkaline phosphatase (4%), increased liver enzymes (2%) Local: Pain at injection site (4%) Neuromuscular & skeletal: Myalgia (10%), joint stiffness (2%) Renal: Increased[drugs.com] Serum bilirubin levels seldom increase above 10 mg/dL, the alkaline phosphatase level and prothrombin time are usually normal or mildly elevated (e.g., 1 to 3 seconds), and[clevelandclinicmeded.com] […] nervous system: Malaise (6%) Dermatologic: Ecchymoses (2%) Gastrointestinal: Nausea (2% to 4%), vomiting (2%) Hematologic & oncologic: Change in WBC count (2%) Hepatic: Increased[drugs.com]

  • Hepatitis A

    Alkaline phosphatase activity also rises relatively late in the course of the infection, and tends to parallel serum bilirubin increases.[clinchem.org] Liver enzymes like aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyl transferase and lactate dehydrogenase were severely elevated.[ncbi.nlm.nih.gov] The most striking laboratory findings include increases of serum aminotransferase activities, serum bilirubin (both total and direct), and serum alkaline phosphatase activity[clinchem.org]

  • Primary Biliary Cirrhosis

    Liver biopsy showed lymphocytic and plasmacytic infiltration in the portal and periportal areas, with numerous areas of bridging centrilobular necrosis, indicating AIH.[ncbi.nlm.nih.gov] We had also observed in the other three groups of patients that the average of the values of γ-glutamyl transpeptidase and alkaline phosphatase increases with the increase[ncbi.nlm.nih.gov] alkaline phosphatase levels results in an improvement of cholestasis as compared to placebo, with a parallel decrease of aminotransferases and immunoglobulin M, as well as[ncbi.nlm.nih.gov]

  • Third Trimester Pregnancy

    The concomitant phenomenon of a third trimester pregnancy with a significant degree of pelvic organ prolapse is extremely rare. We report on a patient with pelvic organ prolapse complicating third trimester pregnancy treated by concomitant cesarean hysterectomy and abdominal sacrocolpopexy. A 30-year-old woman,[…][ncbi.nlm.nih.gov]

    Missing: Liver Biopsy showing Periportal Necrosis
  • Chronic Alcoholism

    The concept of "structural plasticity" has emerged as a potential mechanism in neurodegenerative and psychiatric diseases such as drug abuse, depression, and dementia. Chronic alcoholism is a progressive neurodegenerative disease while the person continues to abuse alcohol, though clinical and imaging studies show[…][ncbi.nlm.nih.gov]

    Missing: Liver Biopsy showing Periportal Necrosis
  • Infectious Mononucleosis

    Other tests your doctor might order include a complete blood count (CBC) to see if your blood platelet count is lower than normal and if lymphocytes are abnormal, and a chemistry[encyclopedia.com]

    Missing: Liver Biopsy showing Periportal Necrosis
  • Choledocholithiasis

    Pathophysiology [ edit ] This obstruction may lead to jaundice, elevation in alkaline phosphatase, increase in conjugated bilirubin in the blood and increase in cholesterol[en.wikipedia.org] An increased serum alkaline phosphatase activity, jaundice, and a dilated common bile duct are characteristic signs of common duct stones, but are not specific.[link.springer.com]

    Missing: Liver Biopsy showing Periportal Necrosis
  • Hepatocellular Carcinoma

    Routine liver function tests, coagulation parameters, complete blood count, and serum chemistries should be ordered for any patient with decompensated liver disease and suspicion[clinicaladvisor.com] Rarely, hemoperitoneum in a cirrhotic patient may shine the light on HCC after a sudden increase in alkaline phosphatase and aspartate transaminase/alanine transaminase levels[docksci.com] […] in gamma-glutamyl transpeptidase/alkaline phosphatase in non-cirrhotic patients( 45, 52 ).[doi.org]

    Missing: Liver Biopsy showing Periportal Necrosis

Similar symptoms