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21 Possible Causes for Alkaline Phosphatase Increased, Craniotabes, Muscle Cramp

  • Familial Hypophosphatemia

    cramps Bone pain with frequent fractures due to weak bones.[] alkaline phosphatase levels is a typical laboratory profile in patients with XLH rickets.[] cramps since 1990 with consecutive abuse of analgesics, frequent psychogenic, and rare epileptic seizures since 1990, iron-deficient normocytic and normochrome anemia since[]

  • Vitamin D Deficiency

    History Non-specific bone / muscular pain; fatigue with exercise Symptoms of low calcium: muscle cramps, tetany, seizures (rare beyond 6 months of age) Time outdoors Dairy[] Juvenile Paget's disease (JPD) is a rare heritable osteopathy characterized biochemically by markedly increased serum alkaline phosphatase (ALP) activity emanating from generalized[] The incidence of craniotabes was scored each month.[]

  • X-Linked Hypophosphatemia

    cramps Bone pain with frequent fractures due to weak bones.[] Paricalcitol decreased alkaline phosphatase activity in adults by 21% (no change with placebo, P .04).[] […] enlarged costochondral junctions of the ribs, pectum carinatum, metaphyseal flaring of the wrists or ankles, genus varus, frontal bossing enlarges sutures and fotanels or craniotabes[]

  • Rickets

    This can make the symptoms of rickets worse and can also cause muscle cramps, twitching, tingling in the hands and feet, and fits.[] Serum alkaline phosphatase decreased and calcium increased similarly in all groups.[] First leading clues to rickets on physical examination are poor growth, especially length, thickening of wrists, bow legs, and craniotabes.[]

  • Osteomalacia

    ) Craniotabes is also seen in syphilis, and neonates with this are often tested for the disease.[] This can make the symptoms of rickets worse and can also cause muscle cramps, twitching, tingling in the hands and feet, and fits.[] Renal dysfunction, hypophosphatemia and increased levels of bone alkaline phosphatase were found.[]

  • Osteoporosis

    , muscle cramps, high blood pressure, irregular heartbeat).[] Increased rates of osteoclastic bone resorption, measured by the level of collagen breakdown products, as well as increased bone formation, measured by bone-specific alkaline[] Features can include growth failure, craniotabes, craniosynostosis, blue sclerae, costochondral enlargement ("rachitic rosary"), scoliosis, thickening of wrists and ankles[]

  • Hereditary Neonatal Hyperparathyroidism

    Perioral paraesthesia and cramps are the commonest symptoms of hypocalcaemia of any cause. Does the patient complain of muscle cramps or twitching?[] Our patient remained mildly hypercalcemic (10.5–12.7 mg/dl) and dose increases were performed for values above 12 mg/dl while targeting a normal PTH and alkaline phosphatase[] Bowing of the forearms, craniotabes, frontal bossing, and enlarged fontanelles are preambulatory signs of rickets in older infants.[]

  • Vitamin D

    Vitamin D is important for good muscle health. People with very low Vitamin D blood levels may be more likely to experience muscle cramps, bone, or joint pain.[] Serum phosphate usually decreases, and serum alkaline phosphatase usually increases. Serum PTH may be normal or elevated.[] ., Momoi, T.. ( 2008 ) Craniotabes in normal newborns: the earliest sign of subclinical vitamin D deficiency . J Clin Endocrinol Metab 93: 1784 – 1788 .[]

  • Pregnancy

    Symptoms include extreme tiredness trouble dealing with cold muscle cramps severe constipation problems with memory or concentration You may have symptoms of hypothyroidism[] […] osteoporosis. 24 , 25 Additionally, low vitamin D during the fetal and neonatal period has been associated with delayed fetal growth, osteopenia, impaired fetal bone ossification, craniotabes[] Positional discomfort, leg cramps, breast tenderness, and anxiety can also contribute to poor sleep. Pregnancy also impacts sleep architecture.[]

  • Hypocalcemic Vitamin D-Dependent Rickets

    TOC Lytes Hypocalcemia SX: muscle cramp; & tetany, paresthesia, confusion, convulsion, stridor & drypsnea, diplopia, abd.cramps, urin. frequency, Chvostek's sign (1-2 contractions[] Increased alkaline phosphatase. Increased phosphaturia. Increased levels of parathyroid hormone. Morphological changes Demineralization of the skeleton.[] Rickets is a disease characterized by bone deformities, enlargement of the wrists and costochondral junctions, decreased muscle tone and, in infants, craniotabes and delayed[]

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