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77 Possible Causes for Alkaline Phosphatase Increased, Early Onset Puberty

  • Menopause

    Premature (early onset) menopause is when periods stop before the age of 40 years. Why does menopause occur?[] The serum levels of calcium, osteocalcin, and alkaline phosphatase and osteoblast density in the tibia were increased, but the density of osteoclast was decreased in OVX rats[] At puberty, hormones produced by the pituitary gland in the brain stimulate the ovaries to begin releasing eggs each month (ovulation).[]

  • Apathetic Thyrotoxicosis with Thyrotoxic Crisis

    Hormone Imbalance may have the following effects on a woman's body: * "Thyroid disorders can cause abnormally early or late onset of puberty and menstruation.[] . 6) Elevated serum alanine aminotransferase ( ALT ) and alkaline phosphatase ( ALP ) levels. 7) Minor increases in serum total and ionized calcium levels. 3.[] […] in bone resorption, is also common. 15 This increase in osteoblastic bone activity can also lead to elevations in alkaline phosphatase. 15 Prevention of thyroid storm is[]

  • Osteogenesis Imperfecta

    puberty/early adulthood Age 20 to 40s usually at birth birth corneal thinning central or paracentral inferior crescent-shaped band 1-2 mm wide generalized and slightly more[] Blood calcium, phosphate, albumin, fasting urinary calcium/creatinine ratio, total serum alkaline phosphatase, and bone alkaline phosphatase were obtained at baseline and[] Levels of biochemical markers of bone metabolism generally were within the reference range, but serum alkaline phosphatase and urinary collagen type I N-telopeptide excretion[]

  • Systemic Mastocytosis

    A childhood onset form is distinguished from the adult onset form by its early appearance (usually within the first year of life) and good prognosis with spontaneous resolution[] In multivariate analysis of all patients, an increased spleen volume 450 ml (hazard ratio (HR), 5.2; 95% confidence interval (CI), (2.1-13.0); P 0.003) and an elevated alkaline[] Preoperative laboratory investigations were normal, except for moderate anemia (hemoglobin 99 g/L), increased alkaline phosphatase (196 U/L, normal 36-108 U/L), and decreased[]

  • Hereditary Neonatal Hyperparathyroidism

    […] diabetes mellitus (82%) Childhood obesity Hypogonadism Hypothyroidism Major Hypertriglyceridaemia HypoHDLemia ALMS I gene mutation Insulin-sensitiser Insulin therapy Cystinosis early-onset[] phosphatase Type Ia pseudohypoparathyroidism (Albright hereditary osteodystrophy) High PTH High serum PO 4 No urinary cAMP or increase in PO 4 excretion even after injection[] Late diagnosis is associated with markedly advanced skeletal maturation and accelerated linear growth initially, but early natural puberty and ultimately short stature.[]

  • Central Precocious Puberty

    Precocious puberty refers to early onset puberty symptoms. Central precocious puberty (CPP) is the more common type.[] Paraneoplastic features of hepatoblastoma are not uncommon at presentation and include thrombocytosis and increased alkaline phosphatase [2].[] Paraneoplastic features of hepatoblastoma are not uncommon at presentation and include thrombocytosis and increased alkaline phosphatase [ 2 ].[]

  • Growth Failure

    In addition, a growth disorder called precocious puberty is characterized by an early onset of adolescence in which a child is tall for his or her age initially, but, due[] Healing occurs in 2–4 weeks and can be monitored from the lowering of alkaline phosphatase, increasing vitamin D levels and healing on X-rays, but complete reversal of bony[] Precocious puberty.[]

  • Osteoporosis

    The deficiency can be the result of late onset of puberty/getting their period, early menopause (before 40), or an absence or suppression of menstruation.[] Increased rates of osteoclastic bone resorption, measured by the level of collagen breakdown products, as well as increased bone formation, measured by bone-specific alkaline[] Late onset of puberty and early menopause reduce lifetime estrogen exposure in women and also increase the risk of osteoporosis. Medications.[]

  • Pseudogout

    In men, uric acid levels rise at puberty, and the peak age of onset of gout in men is in the fourth to sixth decade of life.[] […] of alkaline phosphatase and γ- glutamyltransferase, normal iron studies, negative rheumatoid factor, positive antinuclear antibody (1/320 homogeneous pattern), negative extractable[] TNF-alpha and IL1-beta inhibits RUNX2 and collagen expression but increase alkaline phosphatase activity and mineralization in human mesenchymal stem cells.[]

  • Pediatric Crohn Disease

    Delayed growth and onset of puberty (looking younger than your peers) will have a significant negative impact on the child's psychosocial development and self‐image.[] Bone-specific alkaline phosphatase levels, a biomarker of bone formation, increased a median of 75% (P .001) during induction with associated 12-month improvements in trabecular[] The transition from early (dependent on parents) to late adolescence (dependent on self) can be particularly difficult for a child with chronically active IBD.[]

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