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13 Possible Causes for Alkaline Phosphatase Increased, Enlargement of the Spleen, Swinging Fever

  • Liver Cirrhosis

    Fever In general, the condition can be diagnosed with the physical examination or blood tests , however liver biopsy can be performed to find out the level of tissue scarring[advancells.com] Splenomegaly (enlarged spleen) e. Hepatic encephalopathy (drowsiness or confusion due to inability of the liver to break down toxins in the blood) f.[singhealth.com.sg] […] bilirubin (without increase in alkaline phosphatase) (See web-based course on liver function test abnormalities .)[hiv.va.gov]

  • Miliary Tuberculosis of the Liver

    The physical examination may reveal the following: Enlarged liver and spleen Swollen lymph nodes The TB skin test, also known as purified protein derivative (PPD) test or[dovemed.com] The laboratory investigations frequently show an increase in alkaline phosphatase, with normal to mildly increased transaminases, anemia, hypoalbuminemia, hypergammaglobulinaemia[academic.oup.com] Our case also had similar findings with mild derangements of liver transaminases and an increased alkaline phosphatase level.[hepatitis.imedpub.com]

  • Chronic Malaria

    The fever is referred to as a ‘swinging fever’ and the duration between fevers may point to a certain type of malaria: P. ovale/P. vivax 38-42 hours between fevers (‘tertian[southsudanmedicaljournal.com] […] of the spleen, emaciation, mental depression, sallow complexion, edema of the ankles, feeble digestion, and muscular weakness.[medical-dictionary.thefreedictionary.com] The abdomen is enlarged, owing to hypertrophy of the liver and spleen; hence there is great dullness on percussion.[henriettes-herb.com]

  • Graves Disease

    […] emotional swings, confusion, psychosis, coma, nausea, vomiting, diarrhea, and hepatomegaly with mild jaundice.[msdmanuals.com] Symptoms may include: Low birth weight Small or abnormally shaped head Poor weight gain despite adequate caloric intake Enlarged liver and spleen Goiter Fast heartbeat (which[stanfordchildrens.org] They can include: Low birth weight Small or abnormally shaped head Poor weight gain (failure to thrive) Enlarged liver and spleen Swelling of the front of the neck due to[urmc.rochester.edu]

  • Adult-Onset Still Disease

    In hospital it was found that she had swollen joints, a high swinging fever and blood tests that were consistent with severe inflammation.[nras.org.uk] […] lymph nodes (lymphadenopathy) Enlarged liver or spleen (hepatomegaly or splenomegaly) Abnormal liver function test Negative rheumatoid factor and negative ANA blood tests[dovemed.com] In the bone marrow aspiration, we found remarkable hyperplasia and granulocytes of each mature state, without an increase of myeloblasts, the neutrophil alkaline phosphatase[springerplus.springeropen.com]

  • Disseminated Tuberculosis

    Mild enlargement of the spleen, liver and pronounced densification of the peritoneum was also observed, with no peritoneal effusion.[sciforschenonline.org] Alkaline phosphatase level may be increased. High transaminase levels may be caused by hepatic involvement or drug toxicity.[symptoma.com] Miliary tuberculosis can also present with enlarged liver (40% of cases), enlarged spleen (15%), inflammation of the pancreas ( multiple organ dysfunction with adrenal insufficiency[en.wikipedia.org]

  • Hepatitis B

    Interferon side effects Interferon causes several side effects including: fatigue , generalized muscle aches , fever, chills and loss of appetite.[medicinenet.com] […] liver and spleen.[symptoma.com] […] serum alkaline phosphatase (4%), increased liver enzymes (2%) Local: Pain at injection site (4%) Neuromuscular & skeletal: Myalgia (10%), joint stiffness (2%) Renal: Increased[drugs.com]

  • Hyperthyroidism

    […] weakness, extreme restlessness, confusion, emotional swings or psychosis, and perhaps even coma.[encyclopedia.com] Symptoms may include: Low birth weight Small or abnormally shaped head Poor weight gain despite adequate caloric intake Enlarged liver and spleen Goiter Fast heartbeat (which[stanfordchildrens.org] […] bowel movements weight loss ReproductiveSystem: Irregularmenstrual cycle Lab Manifestations: Anemia Low cholesterol High Calcium High alkaline Phosphatase. 7 Diagnosis Blood[flexikon.doccheck.com]

  • Massive Hepatic Necrosis

    Clinical Course: In his first 4 days in the hos- pital, he was studied very extensively, prin- cipally for arthritis, jaundice, and high swinging fever, as high as 106 F.[nap.edu] […] elevation of serum alkaline phosphatase and bilirubin.[annals.org] Congestive heart failure with enlargement of the liver to one fingerbreadth below the right costal margin and enlargement of the spleen occurred.[nap.edu]

  • Chronic Active Hepatitis B

    Interferon side effects Interferon causes several side effects including: fatigue , generalized muscle aches , fever, chills and loss of appetite.[medicinenet.com] They can include An enlarged spleen Small spiderlike blood vessels visible in the skin (called spider angiomas) Redness of the palms Accumulation of fluid within the abdomen[merckmanuals.com] The mean value of serum Alkaline Phosphatase (ALP) in patient with acute hepatitis is in accordance with [ 40 ] in chronic hepatitis, the mean value of alkaline phosphatase[omicsonline.org]

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