Create issue ticket

1,195 Possible Causes for Alkaline Phosphatase Increased, Flattening of the Talar Dome, Mutation in the PHEX Gene

  • X-Linked Hypophosphatemia

    To date, 131 mutations in the PHEX gene have been reported.[ncbi.nlm.nih.gov] […] shortening of the talar neck and flattening of the talar dome.[ncbi.nlm.nih.gov] Paricalcitol decreased alkaline phosphatase activity in adults by 21% (no change with placebo, P .04).[ncbi.nlm.nih.gov]

  • Familial Hypophosphatemia

    X-linked dominant hypophosphatemic rickets, due to mutations in the PHEX gene, is the most common inherited form of the disorder.[genedx.com] […] serum alkaline phosphatase level Tetany Calcium, magnesium, vitamin D malabsorption Hypocalcemia, hypophosphatemia, increased serum alkaline phosphatase level, hypomagnesemia[aafp.org] Review Topic QID: 932 2 increased phosphate level 3 decreased alkaline phosphatase level 4 increased vitamin D level 5 increased parathyroid hormone level ML 1 Select Answer[orthobullets.com]

    Missing: Flattening of the Talar Dome
  • Hereditary Hypophosphatemic Rickets with Hypercalciuria

    This process is due to mutations in the FGF23 and PHEX gene.[ivami.com] When there is a deficiency of vitamin D, the amount of phosphorus and calcium in the blood decreases, the activity of alkaline phosphatase increases, the amount of citrates[encyclopedia2.thefreedictionary.com] The characteristic findings in HR are increased alkaline phosphatase, hypophosphataemia, decreased renal phosphorus reabsorption rate and a normal or increased parathyroid[scielo.mec.pt]

    Missing: Flattening of the Talar Dome
  • Vitamin D Deficiency

    […] in the PHEX gene.[ncbi.nlm.nih.gov] Juvenile Paget's disease (JPD) is a rare heritable osteopathy characterized biochemically by markedly increased serum alkaline phosphatase (ALP) activity emanating from generalized[ncbi.nlm.nih.gov] Laboratory test showed severe hypocalcemia, elevated alkaline phosphatase, normal serum phosphorous, decreased 25(OH) cholecalciferol, increased intact parathyroid hormone[ncbi.nlm.nih.gov]

    Missing: Flattening of the Talar Dome
  • Osteomalacia

    There is no correlation between the severity of the disease and the type or localization of PHEX gene mutations (48).[scielo.br] He had a gastrectomy for cancer 7 years previously, with severe vitamin D deficiency; parathormone and alkaline phosphatase were increased, with reduced serum and urine calcium[n.neurology.org] There causes hypophosphataemia and a raised alkaline phosphatase due to increased osteoblastic activity.[pathology.leedsth.nhs.uk]

    Missing: Flattening of the Talar Dome
  • Rickets

    CONCLUSIONS: Novel and de novo mutations are frequent and PHEX mutations are still the most common genetic defects in the Turkish population.[ncbi.nlm.nih.gov] Biochemical test showed obviously increased alkaline phosphatase (ALP) and parathyroid hormone (PTH), mild hypocalcemia and hypophosphatemia.[ncbi.nlm.nih.gov] Serum alkaline phosphatase decreased and calcium increased similarly in all groups.[ncbi.nlm.nih.gov]

    Missing: Flattening of the Talar Dome
  • Fanconi Renotubular Syndrome

    Genetic testing for mutations in the PHEX, FGF23, DMP1, ENPP1 and SLC34A3 genes did not confirm a genetic diagnosis of hypophosphataemic rickets.[doi.org] phosphatase Greatly elevated alkaline phosphatase High serum alkaline phosphatase Increased alkaline phosphatase Increased serum alkaline phosphatase Last updated: 2/27/2017[rarediseases.info.nih.gov] RESULTS: All recruited patients had hypophosphataemia, increased urinary phosphate excretion and elevated alkaline phosphatase.[ncbi.nlm.nih.gov]

    Missing: Flattening of the Talar Dome
  • Menopause

    The serum levels of calcium, osteocalcin, and alkaline phosphatase and osteoblast density in the tibia were increased, but the density of osteoclast was decreased in OVX rats[ncbi.nlm.nih.gov]

    Missing: Flattening of the Talar Dome Mutation in the PHEX Gene
  • Cholelithiasis

    Patients with increased CBD dilatation more than 5 mm showed statistically significant increases in alkaline phosphatase and gamma-glutamyltransferase.[ncbi.nlm.nih.gov] […] in serum bilirubin concentration, alkaline phosphatase activity, or aspartate transaminase activity.[link.springer.com] CONCLUSIONS: The incidence of cholelithiasis was not increased due to subtotal gastrectomy without vagotomy, but the incidence was higher after Billoth-II compared to Billoth-I[ncbi.nlm.nih.gov]

    Missing: Flattening of the Talar Dome Mutation in the PHEX Gene
  • Fracture

    J Appl Oral Sci. 2018;26:e20180004. doi: 10.1590/1678-7757-2018-0004. Epub 2018 Aug 20. Author information 1 Departamento de Prótese e Materiais Odontológicos, Faculdade de Odontologia, Universidade Federal de Uberlândia, Uberlândia, Minas Gerais, Brasil. 2 Escola Técnica de Saúde, Universidade Federal de Uberlândia,[…][ncbi.nlm.nih.gov]

    Missing: Flattening of the Talar Dome Mutation in the PHEX Gene

Similar symptoms